Biodegradable tissue adhesion patch and preparation method thereof
A tissue and patch technology, applied in the field of biomedicine, which can solve the problems of desorption, limited rupture strength, and decreased adhesion strength.
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Embodiment 1
[0032] Embodiment 1. Layered tissue adhesive patch and its preparation
[0033] figure 1 It exemplarily shows a schematic diagram of the layered structure arrangement in the thickness direction of the tissue adhesive patch sample of this embodiment. like figure 1 As shown, the layered tissue adhesive patch of this embodiment includes an anti-adhesion layer 2, which has a thickness of 10 μm; and a tissue adhesive layer 1, wherein the tissue adhesive layer has a surface for contacting tissue, and includes Poly(N-vinylpyrrolidone), polyacrylic acid and polyacrylic acid polyethylene glycol succinimidyl carboxymethyl ester as multipolymer matrix and polyethylene glycol diacrylate as toughening agent; the anti-blocking layer 2 Having a surface opposite the tissue-contacting surface and comprising poly(lactic-co-glycolic acid).
[0034] The above-mentioned tissue adhesive patch is prepared through the following steps:
[0035] (1) Preparation of anti-adhesive layer: 10g of poly...
Embodiment 2
[0040]Adopt the method identical with embodiment 1, difference is: the charging amount of toughening agent polyethylene glycol and acrylate (PEGDA) are different. Specifically, when preparing the tissue adhesion layer, the dosage of the toughening agent polyethylene glycol diacrylate (PEGDA, Mw=1000Da) was changed to 0.5% of the total weight of the monomer, and a tissue with a thickness of 50 μm was prepared. Adhesive patch sample #2. The ratio of each monomer in the tissue adhesion layer in this embodiment is listed in Table 1 below.
Embodiment 3
[0042] Adopt the method identical with embodiment 1, difference is: the charging amount of toughening agent polyethylene glycol and acrylate (PEGDA) is different. Specifically, when preparing the tissue adhesion layer, the dosage of the toughening agent polyethylene glycol diacrylate (PEGDA, Mw=1000Da) was changed to 2% of the total weight of the monomer, and a tissue with a thickness of 50 μm was prepared. Adhesive patch sample #Y. The ratio of each monomer in the tissue adhesion layer in this embodiment is listed in Table 1 below.
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