Preparation method of water-soluble magnetic sphere

A water-soluble, magnetic sphere technology, applied in the field of macro-scale preparation of magnetic nano-microspheres, can solve problems such as poor dispersibility, and achieve the effects of good magnetic susceptibility, easy scale-up production, and simple and easy-to-obtain raw materials

Pending Publication Date: 2021-08-27
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The SPION prepared by the traditional SPION preparation process as mentioned above has poor dispersibility

Method used

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  • Preparation method of water-soluble magnetic sphere
  • Preparation method of water-soluble magnetic sphere
  • Preparation method of water-soluble magnetic sphere

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preparation example Construction

[0049] The present invention provides a kind of preparation method of water-soluble magnetic ball, and described preparation method comprises the following steps:

[0050] Prepare the citric acid-modified oil-soluble iron ferric oxide nanoparticle solution, provide hydroxyethyl starch or / and dextran solution, add the hydroxyethyl starch or / and dextran solution to the citric acid-modified React in the oil-soluble iron ferric oxide nanoparticle solution to collect water-soluble magnetic balls;

[0051] Wherein, the step of preparing the oil-soluble iron ferric oxide nanoparticle solution modified by the citric acid comprises:

[0052] Prepare the oil-soluble iron ferric oxide nanoparticle solution wrapped with oleic acid, provide a citric acid solution, and add the citric acid solution dropwise to the oil-soluble iron ferric oxide nanoparticle solution wrapped with oleic acid under stirring, The reaction was stirred, the resulting product was mixed with methyl tert-butyl ether,...

Embodiment 1

[0078] A preparation method of small-diameter water-soluble magnetic spheres is realized through the following steps:

[0079] (1) Dissolve 10.8g of ferric chloride hexahydrate and 36.5g of sodium oleate in a mixed solvent consisting of 80mL of absolute ethanol, 60mL of deionized water and 140mL of n-hexane, stir magnetically, heat up to 70°C, condense and reflux After reacting for 4 hours, take the upper organic layer solution from the separatory funnel, wash it three times with 30mL deionized water, remove n-hexane and water by rotary evaporation, and obtain a reddish-brown viscous iron-oleic acid complex;

[0080] (2) Take 36g of the iron-oleic acid complex prepared in step (1) and mix with 64.4g oleyl alcohol and 200g diphenyl ether, stir magnetically, keep the temperature at 100°C for 1h and deoxygenate in vacuum, heat up to 200°C at a constant temperature After 0.5h, a black liquid was obtained, 25g of the reactant was precipitated with 250g of acetone, centrifuged at 70...

Embodiment 2

[0085] A preparation method of small-diameter water-soluble magnetic spheres is realized through the following steps:

[0086] (1) Dissolve 10.8g of ferric chloride hexahydrate and 36.5g of sodium oleate in a mixed solvent consisting of 80mL of absolute ethanol, 60mL of deionized water and 140mL of n-hexane, stir magnetically, heat up to 70°C, condense and reflux After reacting for 4 hours, take the upper organic layer solution from the separatory funnel, wash it three times with 30mL deionized water, remove n-hexane and water by rotary evaporation, and obtain a reddish-brown viscous ferric oleate complex;

[0087] (2) Take 36g of iron-oleic acid prepared in step (1), miscible with 64.4g oleyl alcohol and 200g diphenyl ether, stir magnetically, keep the temperature at 100°C for 1h and deoxygenate in vacuum, heat up to 200°C for 0.5h, A black liquid was obtained, 25g of the reactant was precipitated with 250g of acetone, centrifuged at 7000rpm for 25min, and dried at 110°C to o...

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Abstract

The invention relates to a preparation method of a water-soluble magnetic sphere. The preparation method comprises the following steps: adding a hydroxyethyl starch or / and glucan solution into a citric acid modified oil-soluble ferroferric oxide nanoparticle solution to react, and collecting the water-soluble magnetic sphere. The step of preparing the citric acid-modified oil-soluble ferroferric oxide nanoparticle solution comprises: preparing an oleic acid-coated oil-soluble ferroferric oxide nanoparticle solution, providing a citric acid solution, dropwise adding the citric acid solution into the oleic acid-coated oil-soluble ferroferric oxide nanoparticle solution under stirring, stirring for reacting, mixing the obtained product with methyl tert-butyl ether, and collecting the precipitate. The purpose of macroscopically preparing the water-soluble SPION which is good in dispersity, good in magnetic susceptibility, high in magnetic saturation intensity and free of residual magnetism is achieved.

Description

technical field [0001] The invention relates to the field of macro-preparation of magnetic nano microspheres, in particular to a preparation method of water-soluble magnetic spheres. Background technique [0002] Nanomaterials have surface effect, small size effect, quantum size effect and macroscopic quantum tunneling effect, which make them a hot research object. Due to its unique superparamagnetism, low toxicity and good biocompatibility, superparamagnetic iron oxide nanoparticles (SPION) have become a new focus in the field of medical nanomaterials and targeting research at home and abroad in recent years. Magnetic resonance imaging (MRI), magnetic hyperthermia, cell labeling and imaging, and targeted drug delivery, etc. [0003] The application of SPION in medicine needs to consider three important factors: colloidal stability, biocompatibility and plasma half-life. Among them, the influencing factor of the colloidal stability is the size of the iron oxide crystal nuc...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/36A61K49/12A61K49/18H01F41/02
CPCA61K47/02A61K47/36A61K49/126A61K49/1818H01F41/02
Inventor 万江山张焕宁晓辉郭静芳段婷婷李政海朱荃
Owner 广州康臣药业有限公司
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