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Probiotic compound for treating inflammatory gynecological diseases

A technology of gynecological diseases and probiotics, applied in diseases, microorganisms, silicon compounds, etc., can solve problems such as high recurrence rate, destruction of normal vaginal flora, and drug resistance that cannot be ignored

Pending Publication Date: 2021-08-20
镇江远森医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The use of antibiotics has a positive effect on the control of female gynecological inflammation, but the drug resistance caused by the extensive use of antibiotics cannot be ignored, and antibiotics destroy the normal vaginal flora while inhibiting pathogenic bacteria. Source probiotics to rebuild the micro-ecological environment, but the drug takes a long time, the curative effect is not stable and durable, and the recurrence rate is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A probiotic compound for treating inflammatory gynecological diseases, the probiotic compound includes a compound medium, live probiotic bacteria and a carrier, and the live probiotic bacteria include Lactobacillus and Bifidobacterium;

[0040] The preparation method of the probiotic compound is:

[0041] Activate and expand the culture of Lactobacillus and Bifidobacteria with the first medium, inoculate the cultured strains into the second medium, ferment and cultivate for 12-16 hours to obtain a fermentation liquid, add a freeze-drying protectant, mix After uniformity, the carrier is added, the carrier is soaked, filtered out, and freeze-dried to obtain the probiotic complex; wherein,

[0042] In parts by mass, the composition of the first culture medium is: 10 parts of soybean peptone, 10 parts of beef protein powder, 5 parts of yeast extract, 5 parts of sodium acetate, 20 parts of glucose, 800.1 parts of Tween, 2 parts of ammonium citrate part, 0.58 part of magnesi...

Embodiment 2

[0052] A probiotic complex for treating inflammatory gynecological diseases, the probiotic complex includes a compound medium, live probiotic bacteria and a carrier, and the live probiotic bacteria include Lactobacillus and Bifidobacterium;

[0053] The preparation method of the probiotic compound is:

[0054] Activate and expand the culture of Lactobacillus and Bifidobacteria with the first medium, inoculate the cultured strains into the second medium, ferment and cultivate for 12-16 hours to obtain a fermentation liquid, add a freeze-drying protectant, mix After uniformity, the carrier is added, the carrier is soaked, filtered out, and freeze-dried to obtain the probiotic complex; wherein,

[0055] In parts by mass, the composition of the first culture medium is: 10 parts of soybean peptone, 10 parts of beef protein powder, 5 parts of yeast extract, 5 parts of sodium acetate, 20 parts of glucose, 800.1 parts of Tween, 2 parts of ammonium citrate part, 0.58 part of magnesium...

Embodiment 3

[0066] A probiotic complex for treating inflammatory gynecological diseases, the probiotic complex includes a compound medium, live probiotic bacteria and a carrier, and the live probiotic bacteria include Lactobacillus and Bifidobacterium;

[0067] The preparation method of the probiotic compound is:

[0068] Activate and expand the culture of Lactobacillus and Bifidobacteria with the first medium, inoculate the cultured strains into the second medium, ferment and cultivate for 12-16 hours to obtain a fermentation liquid, add a freeze-drying protectant, mix After uniformity, the carrier is added, the carrier is soaked, filtered out, and freeze-dried to obtain the probiotic complex; wherein,

[0069] In parts by mass, the composition of the first culture medium is: 10 parts of soybean peptone, 10 parts of beef protein powder, 5 parts of yeast extract, 5 parts of sodium acetate, 20 parts of glucose, 800.1 parts of Tween, 2 parts of ammonium citrate part, 0.58 part of magnesium...

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PUM

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Abstract

The invention provides a probiotic compound for treating inflammatory gynecological diseases, and belongs to the field of microbial preparations. The probiotic compound comprises a composite culture medium, viable probiotics and a carrier, wherein the viable probiotics comprise lactobacillus and / or bifidobacterium. A preparation method comprises the following steps: activating the lactobacillus and / or the bifidobacterium by using a first culture medium, performing enlarged culture, inoculating the cultured strain into a second culture medium, performing fermentation culture to obtain fermentation broth, adding a freeze-drying protective agent and a carrier, and performing freeze-drying to obtain the lactobacillus and / or bifidobacterium freeze-dried powder. The second culture medium comprises the first culture medium and soybean polypeptide powder. According to the invention, the vitality of the strain is reserved to the greatest extent through early-stage culture and direct freeze-drying, and besides, a plurality of active substances are introduced on the carrier, so that the carrier can quickly stimulate an immune system to maintain micro-ecological balance, the medication time is shortened, and the medication efficiency is improved.

Description

technical field [0001] The invention relates to the field of functional microbial preparations, in particular to a probiotic compound for treating inflammatory gynecological diseases. Background technique [0002] The scope of female gynecological inflammation is relatively wide. Generally, female reproductive organs, including vulva, Bartholin, vagina, cervix, uterus, fallopian tubes, ovaries, and pelvic peritoneum, are infected by various pathogenic bacteria. Collectively referred to as female gynecological inflammation or reproductive tract infection; existing studies have shown that the occurrence of gynecological inflammation is related to the imbalance of vaginal flora, especially the change of vaginal beneficial bacteria. Key directions of disease. [0003] The use of antibiotics has a positive effect on the control of female gynecological inflammation, but the drug resistance caused by the extensive use of antibiotics cannot be ignored, and antibiotics destroy the n...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K9/00A61K47/26A61K47/02A61K47/32A61P15/02A61P31/04A61P31/10C01B33/40C12N1/20C12N1/04C12P21/06C08F226/02C08F220/38A61K35/745C12R1/225C12R1/23C12R1/245C12R1/25C12R1/01C12R1/685
CPCA61K35/747A61K35/745A61K9/0034A61K47/26A61K47/02A61K47/32A61P15/02A61P31/04A61P31/10C12N1/20C12N1/04C12P21/06C01B33/40C08F226/02A61K2300/00C08F220/387
Inventor 沈刚
Owner 镇江远森医药科技有限公司
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