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Application of dogwood extract in preparation of medicines for inhibiting marine pathogenic bacteria

A technology of dogwood and extract, applied in the field of Chinese herbal medicine extracts, can solve problems such as lack of reports on the application of Chinese herbal medicine, and achieve a good inhibitory effect.

Active Publication Date: 2021-08-17
JIANGSU OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing Chinese herbal medicine is screened to inhibit the research of marine pathogenic bacteria, but there is still a lack of reports about the application of Chinese herbal medicine of the present invention in inhibiting marine pathogenic bacteria

Method used

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  • Application of dogwood extract in preparation of medicines for inhibiting marine pathogenic bacteria
  • Application of dogwood extract in preparation of medicines for inhibiting marine pathogenic bacteria
  • Application of dogwood extract in preparation of medicines for inhibiting marine pathogenic bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1, the screening of Chinese herbal medicines with the effect of inhibiting marine pathogenic bacteria, and it is determined that Cornus officinalis is active in inhibiting marine pathogenic bacteria

[0018] 1. Screening of Chinese herbal medicines that inhibit marine pathogens

[0019] Fourteen kinds of Chinese herbal medicines including thistle, basil, wild jujube, eucalyptus, cassia twig, poria cocos, ageratum, perrin, dogwood, white pod, Polygonum multiflorum, Polygonum multiflorum, Seabuckthorn or Geranium were initially selected. Weigh the powder of traditional Chinese medicine, add solvent (water, ethanol or petroleum ether), ultrasonically extract for 40 minutes, then reflux and extract at 60°C for 2 hours, filter with suction, extract twice in the same way, collect the filtrate, concentrate to make the final concentration of the crude drug 1g / mL.

[0020] Select Vibrio harveyi and Vibrio parahaemolyticus as the target strains, use the Oxford cup metho...

Embodiment 2

[0034] Example 2 Extraction, separation, detection and analysis of effective components of Cornus officinalis for inhibiting marine pathogenic bacteria.

[0035] 1 Extraction of antibacterial active ingredients

[0036] Weigh Cornus officinalis powder, add ethanol, ultrasonically extract at a certain temperature for 40 minutes, then reflux at 60°C for 2 hours, filter with suction, extract twice in the same way, collect the filtrate, and concentrate to make the final concentration of crude drug 1g / mL.

[0037] 2 Separation of antibacterial active ingredients

[0038] The ethanol extract of Cornus officinalis was separated, and the macroporous adsorption resin was used to elute with water, 30% ethanol, 50% ethanol, 70% ethanol, and 90% ethanol, and the eluent was collected to determine the effect of different eluents on Harvey's Bacteriostatic activity of Vibrio. The water-washed part of Cornus officinalis macroporous adsorption resin was dissolved in methanol, separated by sp...

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Abstract

The invention relates to application of a dogwood extract, and belongs to the technical field of application of Chinese herbal medicines in inhibition of marine pathogenic bacteria. The application refers to application of the dogwood extract in preparation of drugs for inhibiting marine pathogenic bacteria. The marine pathogenic bacteria are vibrio harveyi and vibrio parahaemolyticus. According to the invention, the dogwood alcohol extract with the best antibacterial effect is extracted, separated, detected and analyzed, wherein it is determined that the effective component for inhibiting the marine pathogenic bacteria in the dogwood is a phenolic acid compound.

Description

technical field [0001] The invention relates to the technical field of Chinese herbal medicine extracts, in particular to the use of cornus officinalis extracts in preparing medicines for inhibiting marine pathogenic bacteria. Background technique [0002] In recent years, my country's aquaculture industry has developed rapidly, and its fishery output has increased significantly, ranking among the top in the world. However, with the continuous improvement of the scale and intensification of aquaculture, the pollution of aquaculture waters has gradually increased, and diseases caused by aquatic pathogens have occurred frequently, which has seriously hindered the aquaculture and development of seawater fish. Marine pathogenic bacteria mainly include Vibrio parahaemolyticus, Vibrio anguillarum, Vibrio alginolyticus, and Vibrio harveyi. These pathogenic bacteria not only cause huge economic losses to the mariculture industry, but also threaten marine natural biological resource...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P31/04
CPCA61K36/40A61P31/04A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55Y02A50/30
Inventor 刘玮炜邵仲柏蒋凯俊曹联攻陈超吴玉宇苏子钦王有宪刘书豪郭雷
Owner JIANGSU OCEAN UNIV
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