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Targeting controlled-release microcapsule capable of inducing environment information quickly

A technology of controlled release and intelligence, applied in the direction of drug delivery, pharmaceutical formulation, etc., can solve the limitation of drug release rate and drug diffusion rate, and has not yet solved the problem of rapid perception and rapid response speed of drug delivery carrier to environmental information, which cannot be well satisfied. Quickly answer questions such as requests to achieve the effect of improving perception and response speed

Inactive Publication Date: 2003-12-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although researchers in the United States, Japan and other countries have made many basic achievements in the research of intelligent drug controlled release systems, so far they have not solved the problem of rapid perception and immediate response speed of drug delivery carriers to environmental information. The drug release mechanism of the carriers in this type of system is based on the concentration difference as the driving force to make the drug diffuse, so the drug release rate is limited by the drug diffusion rate, which cannot well meet the requirements of rapid response.
[0003] Chu Liangyin and others have developed a kind of environmental information sensing microcapsule system [see "Journal of MembraneScience" 192 (2001), 27-39]. The environmental information sensing type switching valve set in the above-mentioned method is composed of the environment information sensing switch valve. Although the sensing speed of this kind of drug delivery carrier has been greatly improved, the drug release mechanism is still driven by the concentration difference, and it has not fundamentally solved the problem of the intelligent drug control release system. The need for fast sensing speed issues

Method used

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  • Targeting controlled-release microcapsule capable of inducing environment information quickly
  • Targeting controlled-release microcapsule capable of inducing environment information quickly
  • Targeting controlled-release microcapsule capable of inducing environment information quickly

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The structure of the environmental information fast-sensing targeted controlled release microcapsule in this embodiment is shown in Figure 1 and Figure 2. 2 and the environmental information sensing particles 3 located in the capsule. The environmental information sensing switch valve 2 and the environmental information sensing particle 3 are respectively made of polyisopropylacrylamide gel (PNIPAM) or polyacrylic acid / polyacrylamide interpenetrating network gel (PAA / PAAM IPN). The above two gels are temperature-sensitive materials. Among them, polyisopropylacrylamide gel is a negative temperature-sensitive material. When the ambient temperature exceeds its lower critical solution temperature, its material volume shrinks sharply, and polyacrylic acid / polypropylene Amide interpenetrating network gel is a material with positive temperature sensitivity. When the ambient temperature exceeds the low critical solution temperature of the material, the volume of the material wi...

Embodiment 2

[0021] The structure of the environmental information fast-sensing targeted controlled-release microcapsules in this example is the same as in Example 1, and the preparation process is also the same as in Example 1. The difference from Example 1 is that the environmental information sensing switch valve 2 selects -SO 3 H-based or -COOH-based ion gels are made, and environmental information sensing particles 3 are selected to contain -NH 2 based ion gels. The above two gels are pH-sensitive materials, which contain -SO 3 Ionic gels with H groups or -COOH groups are positively sensitive materials, containing -NH 2 The base ion gel is a negative sensing material.

[0022] In this embodiment, it is also possible to use -SO 3 The ion gel of H group or -COOH group is used as the material of particle 3, containing -NH 2 The base ion gel is used as the material of switch valve 2.

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Abstract

The present invention relates to environmental information quick induction target type controlled release micro capsule which is composed of porous microcapsule membrane, environmental information induction type swtich valve set in each hole on capsule membrane and environmental information induction type microparticle positioned in capsule membrane. The switch valve and microparticle are respectively made of polymer gel material with absolutely different environmental information induction property. Under specific environment, the volume of switch valve shrinks and opens the membrane hole, the volume of micro particle expands to produce pushing power and "pump out" the medicine, when the environment is changed, the volume of switch valve expands and the membrane hole is closed and the pushing power on medicine is shutdown. Compared with prior art technology, it can effectively raise the releese velocity of medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of drug controlled release, and particularly relates to a carrier for directly delivering drugs to diseased parts in the body. 2. Background technology [0002] The goal of drug therapy is to deliver the drug directly to the diseased part of the body to obtain the best therapeutic effect without causing any side effects to other parts. The technical system to achieve this goal is called the drug delivery system (Drug Delivery System, referred to as DDS). The drug delivery system has attracted widespread attention, and there are many researchers at home and abroad, especially the intelligent targeted drug release system, which is a research hotspot. The so-called intelligent targeted drug release system uses a carrier to deliver the drug, which can release the drug at a specific location, at a specific time, and at a specific speed according to changes in the surrounding environment information or artific...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/54A61K9/56
Inventor 褚良银陈文梅
Owner SICHUAN UNIV
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