Method for testing suitability of microneedle material suitable for manufacture employing elongation process, and microneedle manufacturing method comprising same

Abstract

A microneedle manufacturing method according to one embodiment of the present invention comprises the steps: selecting and providing a microneedle material, wherein a value of the viscosity / elasticity coefficient of the microneedle material, measured for each shear rate by a viscoelasticity measurement apparatus, belongs to a scope between pre-arranged upper and lower limits; and manufacturing the microneedle material having been selected and provided in the previous step into a microneedle by means of an elongation method.

Description

technical field [0001] The present invention relates to a suitability testing method for a microneedle material prepared by a stretching process and a method for preparing a microneedle comprising the same. Background technique [0002] Many drugs and physiologically active substances have been developed for the treatment of diseases, but in the process of delivering drugs and physiologically active substances into the body, biological barriers (biological barriers, such as skin, oral mucosa, and cerebrovascular barrier, etc.) pass through problems And the efficiency of drug delivery still needs to be improved. [0003] Drugs and physiologically active substances are usually administered orally in the form of tablets or capsules, but due to reasons such as being digested or absorbed in the gastrointestinal tract or being lost by hepatic mechanisms, many drugs cannot be effectively delivered by the above-mentioned methods of administration alone . Moreover, some drugs do no...

AI Technical Summary

Problems solved by technology

Since this method uses a method of pulling a heat-fused or viscous substance using a pin structure, it requires a new process of preparing the pin structure according to the desired pattern, making it difficult to overcome the limitations of increased production costs, due to heating It is difficult to load various heat-sensitive biological drugs (hormones, vaccines, other protein drugs, etc.)

[0015] Due to the limitations of the preparation method, the existing solid microneedles are limited to materials such as silicon, polymer, metal, glass, etc., and due to the use of the preparation method using molding technology, the following disadvantages will occur: due to the complexity and time required for the preparation process Long-term drug denaturation, insufficient hardness and drug loss, etc.

[0019] As mentioned above, there is a difference between the blast stretching method and the centrifugal photolithography method in whether or not the blast solidification process is included, but they are the same in that the microneedle shape is prepared by stretching the viscous composition, which is the same as the above molding different ways

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