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Suspended injection containing gleptoferron and ponazuril and preparation method thereof

A kind of technology of ferric glucoheptonide and injection, which is applied to the suspension injection containing ferric glucohepton and patozuril and the field of preparation thereof, can solve the problem of increasing the cost of drugs, affecting the growth and development of animals, affecting the economic benefits of breeding, etc. problems, to improve animal welfare, reduce dosing workload, and reduce risks

Pending Publication Date: 2021-08-03
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This single-disease, single-treatment model has brought huge workload to the farmers, increased the cost of drugs, and brought huge pressure to the animals, affecting the normal growth and development of animals, and ultimately affecting the economic benefits of farming.

Method used

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  • Suspended injection containing gleptoferron and ponazuril and preparation method thereof
  • Suspended injection containing gleptoferron and ponazuril and preparation method thereof
  • Suspended injection containing gleptoferron and ponazuril and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 comprises the preparation of the suspension injection 1 of Patopazuril and iron glucoheptan

[0061] 1. Prescription composition:

[0062]

[0063]

[0064] 2. Preparation method:

[0065] S1. Take an appropriate amount of water for injection into the liquid mixing tank, and put in the prescribed amount of iron glucoheptose in 2 to 4 times. After putting in all the water, use a high-shear emulsifier at 4000 to 5000 rpm under the condition of 60 to 80 ° C. Stir for 30min under sub-division to obtain initial solution I, which is cooled for subsequent use;

[0066] S2. Put disodium edetate and povidone in the initial solution I into the initial solution I, fully stir and dissolve to obtain the mixed solution II;

[0067] S3. Add the prescribed amount of n-butanol and lecithin to the mixed solution II, heat and stir at 50-70°C until completely dissolved to obtain the suspension III, and cool it for later use;

[0068] S4. Add the prescribed amount of s...

Embodiment 2

[0070] Embodiment 2 comprises the preparation of the suspension injection 2 of Patopazuril and iron glucoheptan

[0071] 1. Prescription composition:

[0072]

[0073]

[0074] 2. The preparation method is the same as in Example 1.

Embodiment 3

[0075] Embodiment 3 comprises the preparation of the suspension injection 3 of Patopazuril and iron glucoheptan

[0076] 1. Prescription composition:

[0077]

[0078] 2. The preparation method is the same as in Example 1.

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Abstract

The invention relates to an injection containing gleptoferron and ponazuril. The injection further comprises pharmaceutically acceptable silicone oil, lecithin, a metal ion complexing agent, n-butyl alcohol, povidone, water and an optional pH regulator. The injection is stable, good in safety and high in bioavailability, and can be used for preventing and treating coccidiosis infection and iron-deficiency anemia of animals at the same time.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a suspension injection containing iron glucoheptose and patopazuril and a preparation method thereof, which are suitable for simultaneously preventing and treating coccidiosis and iron deficiency in animals. Background technique [0002] Coccidiosis and iron deficiency anemia are animal diseases that frequently appear in the process of modern animal husbandry. They occur frequently in young animals. The incidence is high and the disease aggravates rapidly, seriously affecting the growth and development of animals, and even causing death. [0003] Piglets have very limited iron storage (40-50 mg) at birth and iron (about 1 mg / d) obtained from breast milk during lactation, which leads to iron deficiency in piglets in the first week after birth. Clinically, intramuscular injection of iron or indirect iron supplementation to sows is mainly used. Due to the limite...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/53A61K33/26A61K47/10A61K47/18A61K47/24A61K47/32A61K47/34A61P3/02A61P7/06A61P33/02
CPCA61K31/53A61K33/26A61K9/10A61K9/0019A61K47/32A61K47/24A61K47/34A61K47/10A61K47/183A61P7/06A61P33/02A61P3/02A61K2300/00
Inventor 卢山陈清平王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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