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Glutathione stimulation-induced aggregation type composite gold nanoparticles and preparation thereof

A composite nanoparticle and gold nanoparticle technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of inability to use tumor photothermal therapy, inability to produce beneficial effects in tumor diagnosis, and unsatisfactory effects, toxic and side effects, etc. Good biocompatibility, short biological half-life and long circulation time

Active Publication Date: 2021-07-20
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this solution mainly needs to solve the problem of slow release of drugs. It is hoped that the drug can be used to complete the treatment of tumors, which cannot produce beneficial effects on tumor diagnosis and cannot be used in photothermal therapy of tumors. The effect of this material is not good when used in tumor treatment. Ideal and can produce strong toxic side effects

Method used

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  • Glutathione stimulation-induced aggregation type composite gold nanoparticles and preparation thereof
  • Glutathione stimulation-induced aggregation type composite gold nanoparticles and preparation thereof
  • Glutathione stimulation-induced aggregation type composite gold nanoparticles and preparation thereof

Examples

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Embodiment 1

[0042] Example 1: Preparation of glutathione-induced aggregation-type composite gold nanoparticles

[0043] (1) EDC / NHS reaction activates carboxyl group

[0044] Take a certain amount of methoxy-terminated carboxyl polyethylene glycol (mPEG-COOH) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) according to the molar ratio, N-hydroxysuccinimide (NHS) is dissolved in the DMF solution in the glass bottle, add magnetons, put it into a constant temperature magnetic stirrer and react according to the conditions to activate the carboxyl group in the methoxy-capped carboxy polyethylene glycol An O-acylisourea intermediate with activity for coupling amino groups is formed, while NHS is used to increase the stability of the intermediate to increase the yield.

[0045] The specific process is as follows:

[0046] a. Select a 20mL glass bottle after pure and dry treatment as the reaction vessel, put the magnet into it, place it in a magnetic stirrer, and rotate th...

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Abstract

The invention discloses glutathione stimulated-induced aggregation type composite gold nanoparticles and a preparation method thereof. The composite nanoparticles sequentially comprise gold nanoparticles, a polydopamine coating and grafted methoxyl-terminated cystamine amino polyethylene glycol from inside to outside. The size of the composite particles is small, the coated PDA coating and long-chain polyethylene glycol enable the composite particles to have good biocompatibility, phagocytosis of a reticuloendothelial system is reduced, the blood retention time of the composite particles is prolonged, and the composite particles can be efficiently enriched to a tumor area after intravenous injection; after the composite particles reach tumor cells, high-concentration reduced glutathione in a tumor microenvironment reduces disulfide bonds in the composite nano particles into sulfydryl to be broken, after polyethylene glycol is removed from the nano particles, original electrostatic balance among the particles is broken, and after large aggregates are formed, LSPR of the particles is transferred to a near-infrared light area; and the near-infrared light absorption capability of the composite nano particles is enhanced, so that the composite nano particles can be used for photoacoustic imaging and photothermal therapy of tumors.

Description

technical field [0001] The invention belongs to the technical field of nanobiological materials, and in particular relates to a glutathione stimulation-induced aggregation type composite gold nanoparticle and its preparation. Background technique [0002] Cancer is a disease with a high fatality rate caused by abnormal cell production. According to the report of the World Health Organization, the number of people who died of cancer reached 8.8 million in 2015. Common cancer treatment methods are based on drugs, supplemented by chemotherapy or radiation therapy, the purpose of which is to kill tumor cells. However, long-term drug treatment will cause patients to develop drug resistance, and the therapeutic effect will gradually deteriorate. Chemotherapy and radiotherapy will cause equal damage to healthy tissues around the lesion. The side effects of these traditional treatments are more obvious. [0003] Photothermal therapy is a new approach to treat tumors, which has grea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/60A61K47/69A61K49/22A61P35/00B82Y5/00
CPCA61K41/0052A61K49/225A61K47/6925A61K47/60A61P35/00B82Y5/00
Inventor 张磊庄伟江志涛施雯雯沈晶晶范曲立黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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