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A kind of pyrrole and selenium phene-based copolymer nanoparticles and its preparation method and application

A nanoparticle, selenium phene-based technology, applied in the field of nanomaterials, can solve the problems of hindering further application, strong toxic and side effects, poor therapeutic effect, etc., and achieve the effect of easy operation, simple method and good biocompatibility

Active Publication Date: 2022-02-11
ZHENJIANG NO 1 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these traditional therapies have disadvantages such as strong toxic side effects and poor therapeutic effects, which hinder their further application in clinical treatment.

Method used

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  • A kind of pyrrole and selenium phene-based copolymer nanoparticles and its preparation method and application
  • A kind of pyrrole and selenium phene-based copolymer nanoparticles and its preparation method and application
  • A kind of pyrrole and selenium phene-based copolymer nanoparticles and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0047] The preparation of embodiment 1 pyrrole and selenium phene-based copolymer nanoparticles (NPs I-NPs VI)

[0048] (1) Weigh 10g of polyvinyl alcohol, add 100mL of deionized water to prepare a 10% aqueous solution, heat it at 90°C for 3 hours, dissolve it completely, and cool it naturally to 20-25°C.

[0049] (2) Weigh 3 g of ferric trichloride hexahydrate, add deionized water to prepare a 1 g / mL solution, and dissolve it by ultrasonication.

[0050] (3) Take 7.5 mL of 10% polyvinyl alcohol solution prepared in step (1) and 373 μL of 1 g / mL ferric chloride solution prepared in step (2), stir well and mix evenly.

[0051] (4) The pyrrole monomer and selenophene are mixed according to the molar ratio of 0:100, 90:10, 96:4, 97:3, 98:2, 100:0 respectively (the total amount of pyrrole monomer and selenophene is 5mmol), named as NPs I-NPs VI in turn.

[0052] (5) Under the condition of 0-4°C ice bath, slowly add the mixed solution prepared in step (4) dropwise to the mixed solu...

Embodiment 2

[0056] Preparation of Example 2 Pyrrole and Selenium Phenyl Copolymer Nanoparticles

[0057] (1) Weigh 10g of polyvinyl alcohol, add 100mL of deionized water to prepare a 10% aqueous solution, heat it at 90°C for 2.5h, dissolve it completely, and cool it naturally to 20-25°C.

[0058] (2) Weigh 3 g of ferric trichloride hexahydrate, add deionized water to prepare a 1 g / mL solution, and dissolve it by ultrasonication.

[0059] (3) Take 7.5 mL of 10% polyvinyl alcohol solution prepared in step (1) and 373 μL of 1 g / mL ferric chloride solution prepared in step (2), stir well and mix evenly.

[0060] (4) The pyrrole monomer and selenophene were mixed in a molar ratio of 96:4 (the total amount of pyrrole monomer and selenophene was 5 mmol).

[0061] (5) Under the condition of 0-4°C ice bath, slowly add the mixed solution prepared in step (4) dropwise to the mixed solution prepared in step (3), and stir evenly.

[0062] (6) Under the condition of 0-4° C. ice bath, the mixed soluti...

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Abstract

The invention relates to a pyrrole and selenophene-based copolymer nanoparticle, a preparation method and application thereof. The copolymer nanoparticle of the invention uses polyvinyl alcohol as a stabilizer, iron trichloride hexahydrate as an oxidant, and adopts different proportions of pyrrole and selenophene as monomers to be synthesized in situ. The preparation method of the copolymer nanoparticle of the present invention is simple, easy to operate, has near-infrared II region photothermal, photodynamic efficacy and good biocompatibility, and can be used as a good anticancer photothermal agent and photosensitizer.

Description

technical field [0001] The invention belongs to the field of nanometer materials, in particular to a pyrrole and selenium phene-based copolymer nanoparticle. Background technique [0002] At present, cancer is still the most serious challenge to human health. Traditional cancer treatment methods include chemotherapy, radiotherapy and surgical resection. However, these traditional therapies have disadvantages such as strong toxic side effects and poor therapeutic effects, which hinder their further application in clinical treatment. Therefore, it is a difficult problem to be solved urgently to explore new therapeutic methods with high efficiency and low toxicity. [0003] In recent years, the application of nanomedicine has provided more strategies for tumor treatment. Compared with traditional tumor treatment methods, photothermal therapy and photodynamic therapy have attracted great attention of researchers due to their high efficiency and low toxicity. Phototherapy refe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K41/00A61P35/00
CPCA61K9/5138A61K41/0052A61K41/0057A61P35/00A61K2300/00
Inventor 闻向梅钱军林江马吉春钱炜冯炜金晔陈雨
Owner ZHENJIANG NO 1 PEOPLES HOSPITAL
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