Eye cream for dry eyes as well as preparation method and application of eye cream
A dry eye cream, dry eye technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc.
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Embodiment 1-5
[0054] The formula components involved in embodiment 1-5 are as shown in table 1.
[0055] The formula of table 1 embodiment 1-5
[0056]
[0057] The preparation method is as follows:
[0058] 1) Preparation of borneol camphor extract (dextroborneol): extracting dextroborneol from borneol camphor by steam distillation. The specific process is described as follows: Weigh 100g of borneol camphor leaves, wash them with distilled water, grind them with scissors, put them into a three-necked flask, add 800mL of distilled water, control the temperature at 115°C and heat at a constant temperature, stop heating after 1h, and filter with ethyl acetate. The obtained solution was washed, dried by adding an appropriate amount of anhydrous sodium sulfate, and vacuum-dried to obtain the crude natural borneol. The crude product was eluted using petroleum ether-ethyl acetate (mass ratio: 200:1) silica gel column chromatography gradient to obtain borneol (dextroborneol).
[0059] 2) Pre...
Embodiment 6
[0066] Stability, safety and animal experiment curative effect evaluation of embodiment 6 d-borneol eye cream
[0067] Therapeutic effect of dexborneol eye cream on dry eye mice
[0068] Establishment of benzalkonium bromide dry eye model: female C57BL / 6 mice aged 10-12 weeks were instilled with 1 g / L benzalkonium bromide for 7 days, 3 times a day. The intervention group adopted the operation method of Example 1 to prepare D-borneol eye cream. Solvent group adopts the operation method of embodiment 1, increases E phase content to replace borneol camphor. Eye-dosing method: use a hair scraper to remove the hair around the eyes of the mouse, then use the above-mentioned eye cream, 3 times a day, and apply it to the eye area of both eyes.
[0069] Apply D-Borneol eye cream to the eyes of benzalkonium bromide-induced dry eye model mice, compare dry eye group (DryEye), solvent group (Vehicle) and D-Borneol eye cream group (Borneol camphor) in the treatment Changes of various i...
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