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Application of composition in preparation of medicine for treating Alzheimer's disease

A technology of Alzheimer's disease and composition, which is applied in the field of medicine, can solve problems such as the inability to effectively prevent the death threat of Alzheimer's disease, and achieve the effects of treating neurodegenerative diseases, reducing inflammatory reactions, and inhibiting damage

Active Publication Date: 2021-06-18
BEIKE HUAXIA BIOMEDICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In related technologies, clinical drugs can only slow down the degree of cognitive and memory impairment of patients in the course of the disease, but cannot effectively prevent the threat of death that may be caused by Alzheimer's disease

Method used

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  • Application of composition in preparation of medicine for treating Alzheimer's disease
  • Application of composition in preparation of medicine for treating Alzheimer's disease
  • Application of composition in preparation of medicine for treating Alzheimer's disease

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Embodiment Construction

[0048] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0049] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0050] Cytotoxicity detection of geranium and L-serine

[0051] Using HT22 mouse hippocampal neuron cells as the experimental object, the cytotoxicity of geranium and L-serine were detected respectively.

[0052] The specific experimental steps are:

[0053] Inoculate HT22 mouse hippocampal neuron cells (5×10 5 per well) and incubated for 24 hours. Then use dimethyl sulfoxide (DMSO) and DMEM medium (containing 10% FB...

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Abstract

The invention discloses an application of a composition in preparation of a medicine for treating Alzheimer's disease. The composition contains pelargonisin and L-serine. The composition disclosed by the invention can generate an inhibiting effect on nerve cell injury caused by glutamate and reduce cell apoptosis. In addition, the composition can also reduce hyperphosphorylation of Tau in cells caused by okadaic acid molding. Meanwhile, the composition can significantly improve the learning and memory ability and learning and memory behaviors of animals in space and direction, alleviates inflammatory response of a brain, and has an excellent treatment effect on Alzheimer's disease and other neurodegenerative diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a composition in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease, also known as senile dementia, is a degenerative disease. Studies have shown that only 1%-2% of Alzheimer's disease is inherited in an autosomal dominant manner, and the etiology of most Alzheimer's patients is complex and cannot be explored. The course of Alzheimer's disease is generally 5-12 years. During the course of the disease, the cognitive and memory impairment of the patient will become more and more serious with age, and even lead to death. In related technologies, clinical drugs can only slow down the degree of cognitive and memory impairment of patients in the course of the disease, but cannot effectively prevent the death threat that Alzheimer's disease may cause. [0003] Therefore, developing a drug or pharmaceutical composition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/198A61P25/28A61P25/14A61K36/31
CPCA61K31/352A61K31/198A61P25/28A61P25/14A61K36/31A61K2300/00
Inventor 刘兵董俊军高恩恩邓联武吕行直张诗龙李玉川陈能安刘晓月
Owner BEIKE HUAXIA BIOMEDICAL TECH CO LTD
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