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Device and method for improving intraoperative etomidate blood concentration detection sensitivity

A technology of etomidate and blood drug concentration, which is applied in the direction of measuring devices, material analysis through electromagnetic means, instruments, etc., to achieve the effects of improving sensitivity, shortening analysis time, and improving detection sensitivity

Inactive Publication Date: 2021-06-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the detection of etomidate plasma concentration by ion mobility spectrometer at home and abroad

Method used

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  • Device and method for improving intraoperative etomidate blood concentration detection sensitivity
  • Device and method for improving intraoperative etomidate blood concentration detection sensitivity
  • Device and method for improving intraoperative etomidate blood concentration detection sensitivity

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Effect test

Embodiment 1

[0038] figure 2 The graph of the relationship between the concentration of acetone and the migration time of the reagent ion peak is given;

[0039] Qualitative analysis is based on the mobility calculated from the migration time by the ion mobility spectrum. Such as figure 2 As shown, when the concentration of acetone changes, the corresponding migration time is different. The change in acetone concentration is achieved by changing the signal intensity of the acetone reagent ion peak. In the figure, 6 acetone concentrations are adjusted, and the corresponding acetone migration times are different. At the first acetone concentration, the ion peak migration time of the acetone reagent is at 5.80ms; at the sixth acetone concentration, the ion peak migration time of the acetone reagent is at 6.44ms. Select different acetone concentrations, and the migration time of acetone is different, which is beneficial to the peak of the etomidate peak. Peak separation.

Embodiment 2

[0041] image 3 The ion mobility spectrum of 5ppm etomidate qualitative analysis under the positive ion mode of the method in the present invention is given.

[0042] Device and method among the present invention, transfer tube temperature 90 DEG C, drift gas (air) flow rate 400sccm, carrier gas (air) flow rate 300sccm, halogen light illumination 20S; Adjust acetone concentration control acetone reagent ion peak migration time when 5.80ms, The peak migration time of etomidate monomer was 9.60ms, which was used as the standard for qualitative analysis in follow-up experiments.

Embodiment 3

[0044] Figure 4 The standard curve of quantitative analysis of different concentrations of etomidate under the positive ion mode of the method of the present invention is given;

[0045] In the device and method of the present invention, the transfer tube temperature is 90°C, the drift gas (air) flow rate is 400 sccm, the carrier gas (air) flow rate is 300 sccm, and the halogen lamp is illuminated for 20S; under the positive ion mode, according to the migration time of etomidate, continuous collection In the ion mobility spectrum 30S, the standard curve equation is established with the blood drug concentration as the abscissa and the sum of the peak areas of the thermal analysis signal spectrum as the ordinate. Such as Figure 4 , the standard curve equation is Y=1381.64*X+1326.22, the correlation coefficient R 2 >0.99. The established qualitative and quantitative analysis methods meet the range of concentration analysis of human body administered by doctors to anesthetize...

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Abstract

The invention discloses a device and a method for improving intraoperative etomidate blood concentration detection sensitivity. According to the method, an ion mobility spectrometry technology is taken as a basic detection technology, a rapid solvent extraction pretreatment method is utilized, an optimal dopant reagent ion control adding method is adopted, and a halogen lamp heating rapid analysis method and a pulse valve boosting flow control instant sample injection method are combined to realize intraoperative online high-sensitivity detection of etomidate in blood. The detection and analysis time of a single sample is less than 30 seconds. The detection sensitivity is high, and the measurement detection limit can reach 0.01 [mu]g / ml; the quantitative analysis concentration range of etomidate in blood is 0.1-10 [mu]g / ml. The device is stable and reliable, and the method is simple, rapid and efficient. The detection method disclosed by the invention can be widely used for deep online analysis of intraoperative clinical etomidate administration, guiding doctors to carry out clinical precise medication, and laying a foundation for researching intraoperative etomidate anesthetic pharmacokinetics.

Description

technical field [0001] The invention belongs to the field of pharmaceutical analytical chemistry, and in particular relates to a device and a method for improving the detection sensitivity of etomidate blood drug concentration during operation. Background technique [0002] Etomidate is a derivative of imidazole, and its chemical name is R-(+)-ethyl-1-(1-phenethyl)-1-hydrogen-imidazole-5-carboxylate. Etomidate has a molecular weight of 244 and is used for induction of general anesthesia. Requirements for compounds suitable as general anesthetics: stable physical and chemical properties, non-toxic, rapid distribution, metabolization and excretion, so that the anesthesia process can achieve "quick anesthesia and quick awakening"; due to these characteristics, rapid dynamic monitoring of anesthetics is difficult. Usage and dosage: Adults: 150-300ug / kg body weight, intravenous injection, children under 15 years old and the elderly 150-200ug / kg body weight, intravenous injection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/622
CPCG01N27/622
Inventor 王新李海洋张远智肖瑶蒋丹丹
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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