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Preparation method of janus structure hemostatic with directional driving function

A hemostatic agent and functional technology, applied in the field of preparation of janus structure hemostatic agents with directional drive function, can solve the problems of unsatisfactory hemostatic effect, unguaranteed bubble driving efficiency and durability, and achieve good biodegradability, good biological Compatible, easy-to-process effects

Active Publication Date: 2021-06-04
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems in the prior art that the driving efficiency and durability of the air bubbles cannot be guaranteed, the irregular or curved wounds cannot penetrate deep into the bleeding point in the wound for effective sealing, and the hemostatic effect is not ideal, etc., and provides a realizable Preparation method of hemostatic agent for continuous and strong movement against the direction of blood flow in irregular or curved wounds to bleeding points deep in the wound

Method used

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  • Preparation method of janus structure hemostatic with directional driving function
  • Preparation method of janus structure hemostatic with directional driving function
  • Preparation method of janus structure hemostatic with directional driving function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method with directional drive function janus structure hemostatic agent, comprising the following steps:

[0047] S1: Add 40g of cornstarch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 40°C and stir at a speed of 250r / m for 10h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.6 g of sodium carbonate and 1.2 g of sodium trimetaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to cornstarch is 2: 100.

[0048] S2: Stir and mix 10g of the esterified m...

Embodiment 2

[0053] A preparation method with directional drive function janus structure hemostatic agent, comprising the following steps:

[0054] S1: Add 40g of tapioca starch to 200ml of sodium acetate buffer solution containing α-amylase and glucoamylase at a pH of 4.6 to react, heat at 35°C and stir at a speed of 250r / m for 12h, filter after the reaction is completed, wash the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 0.2 g of sodium carbonate and 0.8 g of sodium hexametaphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the solution The pH value is 11, after the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase and glucoamylase is 1:4, and the ratio of amylase and tapioca starch is 2: 100.

[0055] S2: Stir and mix 10g of the esterif...

Embodiment 3

[0060] A preparation method with directional drive function janus structure hemostatic agent, comprising the following steps:

[0061]S1: Add 40g of wheat starch to 200ml of sodium acetate buffer solution with a pH of 4.6 containing α-amylase and glucoamylase for reaction, heat at 55°C and stir at a speed of 250r / m for 6h, filter after the reaction is completed, clean the filter residue, and vacuum Dry for 24 hours to obtain microporous starch; then add 20 g of the obtained microporous starch to deionized water containing 2 g of sodium carbonate and 4 g of sodium tripolyphosphate, heat at 50°C for 24 hours, and add sodium hydroxide solution during the reaction to maintain the pH value of the solution After the reaction is completed, add hydrochloric acid, filter, wash and dry to obtain esterified microporous starch; wherein, the ratio of α-amylase to glucoamylase is 1:4, and the ratio of amylase to wheat starch is 2:100.

[0062] S2: Stir and mix 10g of the esterified micropor...

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Abstract

The invention provides a preparation method of a janus structure hemostatic with a directional driving function, aiming at the defects that a bubble-driven powder hemostatic in the prior art has a better effect on deep, penetrating and aortic / venous rupture wounds, but cannot penetrate into bleeding points in deep parts of the wounds to effectively block the irregular or curved wounds, the hemostatic effect is not ideal, and rapid hemostasis cannot be realized. The preparation method comprises the following steps of: carrying out unidirectional self-aggregation on magnetic nano-iron oxide by utilizing esterified microporous starch to obtain esterified microporous starch / nano-iron oxide janus particles; carrying out immobilized assembly on thrombin on the surfaces of the esterified microporous starch / nano-iron oxide Janus particles, and coating the surfaces with sodium bicarbonate to obtain sodium bicarbonate coated and thrombin assembled esterified microporous starch / nano-iron oxide Janus particles; and then mixing the sodium bicarbonate coated and thrombin assembled esterified microporous starch / nano-iron oxide Janus particles with protonated acidic salt powder to obtain the janus structure hemostatic with the directional driving function.

Description

technical field [0001] The invention is applied in the technical field of hemostatic materials, and in particular relates to a preparation method of a janus structure hemostatic agent with directional driving function. Background technique [0002] In order to effectively control massive bleeding, a large number of commercial hemostatic materials have appeared on the market, such as modified cellulose-based hemostatic products Zeolite-based hemostats clay-based hemostat and chitosan-based hemostatic agent CeloxTM and bandage. While these commercial materials have demonstrated the ability to rapidly control massive bleeding, they fail to control severe bleeding in perforated and curved wounds. Because these hemostatic materials can only be applied to the surface of the bleeding wound due to their own shape, function or complex shape of the bleeding wound. Bleeding control is achieved by using its own rapid blood-sucking ability and its own coagulation mechanism to fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/10A61L24/00
CPCA61L24/08A61L24/02A61L24/108A61L24/0015A61L24/0036A61L2400/04A61L2400/12A61L2300/254A61L2300/418C08L3/02C08L89/00
Inventor 蓝广芊李庆胡恩岭陆飞谢瑞琪余堃
Owner SOUTHWEST UNIVERSITY
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