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Traditional Chinese medicine compound preparation for treating liver cancer and application thereof

A compound preparation and technology for the treatment of liver cancer. It is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as far from reaching basic control, skin and intestinal side effects, patient non-response and drug resistance.

Active Publication Date: 2021-06-04
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

HCC is highly resistant to chemotherapy drugs. Targeted drugs Sorafenib and Regorafenib developed in recent years have been listed as first-line and second-line systemic therapy for advanced HCC. The improvement in patient survival was less than 3 months
Moreover, these targeted drugs and chemotherapy drugs have a large number of patients who do not respond and drug resistance, and all have serious skin and intestinal side effects
Although great progress has been made in the diagnosis and treatment of liver cancer in recent years, the goal of basic control of the disease is still far from being achieved

Method used

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  • Traditional Chinese medicine compound preparation for treating liver cancer and application thereof
  • Traditional Chinese medicine compound preparation for treating liver cancer and application thereof
  • Traditional Chinese medicine compound preparation for treating liver cancer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh the raw materials according to the following weights: 12g heterophylla, 12g fried Atractylodes macrocephala, 12g poria cocos, 5g dried tangerine peel, 9g northern root, 9g asparagus, 15g raw astragalus, 9g angelica, 5g Tianlong, 9g Zhinanxing, 9g curcuma, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

Embodiment 2

[0039] Weigh raw materials according to the following weights: 15g heterophylla, 15g fried Atractylodes macrocephala, 15g poria cocos, 6g dried tangerine peel, 9g northern root, 9g asparagus, 30g raw astragalus, 12g angelica, 5g Tianlong, 9g Zhinanxing, 9g zedoary, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

Embodiment 3

[0041] Weigh raw materials according to the following weight: 12g heterophylla, 12g fried Atractylodes macrocephala, 12g poria cocos, 5g tangerine peel, 12g Adenophora radix, 12g asparagus, 15g raw astragalus, 9g angelica, 5g Tianlong, 9g zhinanxing, 9g zedoary, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

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Abstract

The invention discloses a compound preparation for treating liver cancer. The compound preparation is characterized by being prepared from the following raw material medicines in parts by weight: 9-15 parts of radix pseudostellariae, 9-15 parts of roasted rhizoma atractylodis macrocephalae, 9-15 parts of poria, 3-6 parts of pericarpium citri reticulatae, 6-12 parts of radix glehniae, 6-12 parts of radix asparagi, 12-30 parts of raw radix astragali, 6-12 parts of radix angelicae sinensis, 3-6 parts of house lizard, 6-12 parts of rhizoma arisaematis, 6-12 parts of curcuma zedoary, 12-30 parts of herba selaginellae doederleinii and 12-30 parts of cottonrose hibiscus leaves. The compound preparation can be prepared into tablets, granules, capsules or oral liquid by adopting a conventional method. Pharmacodynamics shows that the compound preparation has the effects of improving general conditions of liver cancer patients and inhibiting tumor growth, metastasis and relapse independently or in combination with other liver cancer targeted drugs or chemotherapeutic drugs.

Description

technical field [0001] The invention belongs to the field of research, development and utilization of traditional Chinese medicine, in particular to a compound Chinese medicine preparation for treating liver cancer and its application. Background technique [0002] Liver cancer is a common malignant tumor that is difficult to diagnose and treat and has a very poor prognosis. Among them, hepatocellular carcinoma (HCC) is the most common type, accounting for about 70-85%. Its incidence rate ranks fifth among tumors, and its case fatality rate ranks third. Hepatitis B virus infection and aflatoxin are the main causes of HCC. In recent years, due to hepatitis C virus infection and obesity, the incidence rate in European and American countries has increased significantly. The epithelial-to-mesenchymal transition (EMT) of tumor cells is an important reason for the increase of the malignant degree of liver cancer, which is related to the metastasis, recurrence and drug resistance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/583A61K35/648
CPCA61K36/36A61K36/284A61K36/076A61K36/752A61K36/23A61K36/8965A61K36/481A61K36/232A61K35/648A61K36/8884A61K36/9066A61K36/11A61K36/185A61K35/583A61P35/00A61K2300/00
Inventor 杨金祖宋海燕马耀凯汤凯悦
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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