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Potassium chloride sustained-release tablet prepared by using crab shell powder and derivatives thereof as auxiliary materials and preparation method

A technology of potassium chloride sustained-release tablet and crab shell powder is applied in the field of biomedicine and can solve the problems of non-compliance with the requirements of the pharmacopoeia, fast release rate, low drug load and the like

Pending Publication Date: 2021-06-04
XIAMEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And further, in the patent CN109966505A, a general method of using shrimp shell powder and its porous material treated with acid or alkali as a slow and controlled release carrier material is proposed, but the characteristics, adsorption rules and evaluation methods of the slow release carrier are not discussed in the patent. No in-depth research has been carried out, and the drug loading of the potassium chloride sustained-release agent prepared from shrimp shell powder is low, only 3.9%, the release rate is relatively fast, and the release is basically complete within 10 hours, which does not meet the requirements of the Pharmacopoeia
[0008] The present invention is just based on the previous foundation, aiming at its existing deficiencies, focusing on potassium chloride slow-release tablets, it is found that crab shell powder has a larger specific surface area and higher adsorption capacity than shrimp shell powder, which can overcome the disadvantages of shrimp The series of carriers prepared by shell powder have the disadvantages of low drug loading and fast release, and developed a potassium chloride sustained-release tablet with less excipients, simple preparation process, high drug loading, and long sustained release time.

Method used

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  • Potassium chloride sustained-release tablet prepared by using crab shell powder and derivatives thereof as auxiliary materials and preparation method
  • Potassium chloride sustained-release tablet prepared by using crab shell powder and derivatives thereof as auxiliary materials and preparation method
  • Potassium chloride sustained-release tablet prepared by using crab shell powder and derivatives thereof as auxiliary materials and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1: Prepare Potassium Chloride Sustained-release Tablets with Crab Shell Powder as an auxiliary material

[0085] (1) Weigh 100 g of crab shell raw material, soak in warm water, wash, dry, crush, and sieve to 200 mesh to prepare crab shell powder with a particle size of less than 75 μm (powder passing through a 200 mesh sieve).

[0086] (2) Weigh potassium chloride of different quality, dissolve them in 100mL pure water respectively, and prepare the concentration as 0.01g / mL, 0.05g / mL, 0.10g / mL, 0.15g / mL, 0.20g / mL, 0.25g / mL, 0.34g / mL potassium chloride solution.

[0087] (3) Take by weighing 10g of crab shell powder of step (1), add respectively in the potassium chloride solution of step (2), under the condensing reflux condition of t=100 DEG C, absorb equilibrium for 2 hours, keep stirring during the adsorption process, After 2 hours, it was filtered, dried, and tableted to obtain slow-release tablets of crab shell powder potassium chloride.

[0088] (4) D...

Embodiment 2

[0097] Embodiment 2: prepare potassium chloride slow-release tablet with chitin-protein

[0098] (1) Take by weighing 100g of ground crab shell powder, process with acid-dissolved calcium to obtain chitin-protein composite bio-based material (hereinafter referred to as chitin-protein), the specific steps are as follows:

[0099] Step 1: mix the crab shell powder of Example 1 with 10wt% citric acid solution in a mass ratio of 1:10, stir at a constant temperature of 50°C for 4 hours, and filter while hot with 50°C warm water to obtain a filtrate.

[0100] Step 2: Add 10wt% citric acid solution to the primary filtrate in step 1, perform secondary decalcification according to the same conditions as step 1, wash the secondary filtrate with an appropriate amount of distilled water for several times until neutral, dry to constant weight, It is chitin-protein.

[0101] (2) Weigh potassium chloride of different quality, dissolve them in 100mL pure water respectively, and prepare the c...

Embodiment 3

[0112] Embodiment 3: prepare potassium chloride sustained-release tablet with chitosan-calcium carbonate

[0113] (1) Take by weighing 150g ground crab shell powder, through alkali dissolution protein and deacetylation, obtain chitosan-calcium carbonate composite bio-based material (hereinafter referred to as chitosan-calcium carbonate), concrete steps are as follows:

[0114]Step 1: Dissolve 80g of potassium hydroxide in 40mL of water and mix with 400mL of isopropanol evenly. Dissolve 150g of the crab shell powder of Example 1 in the above-mentioned alcoholic aqueous solution containing dilute alkali, stir at a constant temperature of 65°C for 3 hours, and filter to obtain Once filtered, the filtrate was rotary evaporated to remove isopropanol.

[0115] Step 2: soak the primary filtrate in step 1 with recovered isopropanol at room temperature for 30 minutes, wash until neutral, and dry to constant weight, which is chitosan-calcium carbonate.

[0116] (2) Weigh potassium chlo...

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Abstract

Aiming at the problems of high production cost, complex process, poor sustained release effect, unstable performance, physiological toxicity and the like of the existing sustained and controlled release medicine, the invention provides a potassium chloride sustained-release tablet prepared from crab shell powder and derivatives thereof as auxiliary materials and preparation and evaluation methods of the potassium chloride sustained release tablet. The crab shell powder and a natural nano-porous material treated by acid or alkali are directly used as a sustained-release carrier, the potassium chloride sustained-release tablet which is economic and safe and meets the requirements of pharmacopeia is prepared by a simple solution adsorption method, the potassium chloride content range is 1.0%-60%, the release time is 24-96 hours, the chitosan-calcium carbonate potassium chloride sustained-release tablet and the porous calcium carbonate potassium chloride sustained-release tablet have the best effect, the loading capacity is about 20%, and the release amount meets the stipulation of the second method of the general rule 0931 of the second part of pharmacopoeia. The potassium chloride sustained-release tablet can be prepared by selecting the corresponding sustained-release carrier or the combined carrier according to the requirements on the content and the release rate of the potassium chloride or the sustained-release carrier in an actual application scene, and a novel safe and long-acting sustained-release system is created.

Description

technical field [0001] The present invention relates to a sustained-release carrier and a sustained-release tablet, preferably, relates to a preparation method of a sustained-release tablet, in particular to a slow-release potassium chloride (replenishment) prepared from crab shell powder and an acid- or alkali-treated sustained-release carrier thereof. Calcium) tablets and preparation and evaluation methods thereof belong to the technical field of biomedicine. Background technique [0002] Potassium chloride is an electrolyte replenishment drug, which is clinically used to treat and prevent hypokalemia, but excessive application of potassium ions is toxic to the heart, and may cause side effects such as metabolic acidosis and renal failure in severe cases. Oral preparations used clinically for potassium supplementation include potassium chloride tablets and potassium chloride oral liquid. Generally, 10% potassium chloride water is used to increase blood potassium concentrat...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/20A61K47/46A61K47/02A61K47/36A61K47/42A61P3/12
CPCA61K33/14A61K9/0002A61K9/2009A61K9/2068A61K9/2063A61K9/205A61P3/12
Inventor 尹应武陶诗婷杨少梅廖翠莺师雪琴吐松叶李艺高玉兴陈学云张海双
Owner XIAMEN UNIV
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