Lycium barbarum polysaccharide with blood fat reducing effect

A technology of Lycium barbarum polysaccharide and Lycium barbarum, applied in the field of pharmaceutical chemistry, can solve the problems of wide molecular weight distribution, unclear substance basis and structure of blood lipid-lowering polysaccharide, etc.

Active Publication Date: 2021-05-28
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight distribution of polysaccharides from Lycium barbarum is very wide, and the material basis and structure of polysaccharides with hypolipidemic properties are still unclear.

Method used

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  • Lycium barbarum polysaccharide with blood fat reducing effect
  • Lycium barbarum polysaccharide with blood fat reducing effect
  • Lycium barbarum polysaccharide with blood fat reducing effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Lycium barbarum homogeneous polysaccharide LBP009-2-1 with hypolipidemic effect

[0027] 1. Preparation method of Lycium barbarum homogeneous polysaccharide LBP009-2-1

[0028] 1.1 Instruments, reagents and materials

[0029] DEAE-52 cellulose, Sephadex G-50, standard monosaccharides (arabinose, ribose, xylose, glucose, fructose, mannose, galactose, fucose, rhamnose, galactobionic acid, glucuronic acid and mannose sugar acid). All other chemicals were at least of analytical grade. The solvent for HPLC is chromatographically pure.

[0030] 1.2 Preparation of Lycium barbarum crude polysaccharide

[0031] figure 1 It is a flow chart of separating and purifying Lycium barbarum homogeneous polysaccharide LBP009-2-1 from Lycium barbarum.

[0032] Add 1L of distilled water to 100g of wolfberry, and use a high-speed shear dispersing and emulsifying machine to assist extraction, with a rotation speed of 15,000 rpm and an extraction temperature of ...

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Abstract

The invention provides a lycium barbarum homogeneity polysaccharide with a good blood fat reducing effect, which is prepared by the following steps: separating a lycium barbarum water extract through membranes with the molecular weights of 30kDa, 10kDa and 5 kDa respectively and sequentially; then freeze-drying the lycium barbarum water extract component which penetrates through a 10kDa membrane assembly and is intercepted by a 5kDa membrane assembly, dissolving the extract in distilled water, removing protein, removing pigment and dialyzing the extract; then carrying out column chromatography on the purified product, eluting the product with a sodium chloride solution, collecting the components, dialyzing the component with a 1000Da dialysis bag, freeze-drying the dialyzed product, dissolving the component in distilled water again, further separating the component with sephadex, collecting the components, and freeze-drying the component to complete the preparation. The lycium barbarum polysaccharide provided by the invention has the effect of reducing blood fat and can be used for preparing functional foods, health foods, foods for special medical purposes or new medicines.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical chemistry, and in particular relates to a wolfberry polysaccharide with blood lipid-lowering effect. Background technique [0002] Hyperlipidemia refers to the abnormal increase of one or more lipids in plasma, mainly due to the increase of serum total cholesterol (TC), triglyceride (TG) or low-density lipoprotein cholesterol (LDL-c) levels, and abnormalities in lipid metabolism or transport. With the improvement of people's living standards and changes in diet structure, the number of patients with hyperlipidemia is increasing rapidly, and the age distribution is advancing. The number of young and middle-aged patients with hyperlipidemia has increased significantly. The occurrence of hyperlipidemia is a long process with little direct negative impact on the human body, but it can cause various complications, including atherosclerosis, coronary artery disease, cerebral infarction, cardiov...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P3/06
CPCA61P3/06C08B37/0003C08B37/006
Inventor 邸多隆刘建飞
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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