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Herba cistanche granules as well as preparation method and application thereof

A technology of cistanche deserticola and granules, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as greater human injury, influence on use, toxic and side effects, and enhance immunity. , good taste effect, simple operation effect

Inactive Publication Date: 2020-12-11
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are various chemical hypoglycemic and lipid-lowering drugs on the market, but due to obvious toxic and side effects, long-term use will cause great harm to the human body, such as hepatitis, kidney stones, pancreatitis, anorexia, insomnia, diarrhea, flatulence, abdominal distension, etc. , thus affecting the clinical use of

Method used

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  • Herba cistanche granules as well as preparation method and application thereof
  • Herba cistanche granules as well as preparation method and application thereof
  • Herba cistanche granules as well as preparation method and application thereof

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preparation example Construction

[0034] In the present invention, the grosvenor fruit preferably includes fine powder of grosvenor fruit, and the preparation method of the fine powder of grosvenor fruit preferably includes: crushing the raw material of grosvenor fruit, and passing through a 65-mesh sieve to obtain the fine powder of grosvenor fruit. Said Luo Han Guo not only can provide active ingredients in the present invention, but also has a better flavor-correcting effect, and improves the mouthfeel of Cistanche granules.

[0035] In the present invention, the excipient preferably includes soluble starch and maltodextrin, preferably the weight ratio of the soluble starch to maltodextrin is (3-5):1, more preferably 4:1. The present invention selects soluble starch and maltodextrin as excipients, and limits the specific ratio to ensure that the obtained Cistanche granules have the characteristics of high yield and good hygroscopicity.

[0036] In the present invention, the wetting agent preferably includes...

Embodiment 1

[0051] The extraction method of the total glycosides of Cistanche deserticola is as follows: crush Cistanche deserticola, pass through a 65-mesh sieve to obtain the pulverized product, mix it with an ethanol solution with a volume percentage content of 45%, and the volume ratio of the crushed product to the ethanol solution is 1g:35mL. Extract at 0.5 h for 0.5 h to obtain total glycosides of Cistanche deserticola, and the yield of total glycosides of Cistanche deserticola is 3.92%.

[0052] The extraction method of the total flavonoids of Cistanche deserticola is as follows: crush Cistanche deserticola, pass through a 65 mesh sieve to obtain the pulverized product, mix it with an ethanol solution with a volume percentage content of 65%, and the mass ratio of the pulverized product to the ethanol solution is 1g:10mL. Extract at ℃ for 1 hour to obtain the total flavonoids of Cistanche deserticola, and the yield of the total flavonoids of Cistanche deserticola is 6.42%.

[0053] ...

Embodiment 2

[0060] The extraction method of the total glycosides of Cistanche deserticola is as follows: crush Cistanche deserticola, pass through a 65-mesh sieve to obtain the pulverized product, mix it with an ethanol solution with a volume percentage of 55%, and the volume ratio of the pulverized product to the ethanol solution is 1g:45mL. Extract at ℃ for 2 hours to obtain total glycosides of Cistanche deserticola, and the yield of total glycosides of Cistanche deserticola is 4.05%.

[0061] The extraction method of the total flavonoids of Cistanche deserticola is as follows: crush Cistanche deserticola, pass through a 65-mesh sieve to obtain the pulverized product, mix it with an ethanol solution with a volume percentage content of 75%, and the mass ratio of the pulverized product to the ethanol solution is 1g:20mL. Extract at ℃ for 3 hours to obtain total flavonoids of Cistanche deserticola, and the yield of total flavonoids of Cistanche deserticola is 6.56%.

[0062] The preparatio...

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Abstract

The invention provides herba cistanche granules as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The herba cistanche granules comprise the following raw materials in parts by weight of 50-80 parts of herba cistanche alcohol extract, 15-25 parts of fructus momordicae, 5-25 parts of Chinese wolfberry water extraction liquid, 5-25 parts of hawthorn water extraction liquid, 80-200 parts of an excipient and 50-100 parts of a wetting agent. The preparation method comprises the following steps of mixing and concentrating the Chinese wolfberry water extraction liquid and the hawthorn water extraction liquid to obtain extract, mixing the extract with the herba cistanche alcohol extract and the fructus momordicae to obtain dry paste, crushing the dry paste, mixing the crushed dry paste with the excipient and the wetting agent, and carrying out wet granulation to obtain the herba cistanche granules. The herbacistanche granules disclosed by the invention have the characteristics of good granulation property, good wear resistance and attractive appearance. Experimental results show that the herba cistanchegranules disclosed by the invention have the effects of reducing blood sugar and reducing blood fat.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Cistanche granule and a preparation method and application thereof. Background technique [0002] With the development of society and economy, great changes have taken place in lifestyle and diet, and the diseases caused by it have significant changes. Hyperglycemia and hyperlipidemia are one of the diseases with the highest frequency in modern people. Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. Hyperlipidemia is strictly defined as metabolic disorder of blood lipid or abnormal structure and destination of blood lipid. Complication diseases, s...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K36/64A61K9/16A61K47/36A61K47/10A61K47/46A61P3/10A61P3/06
CPCA61K9/1617A61K9/1652A61K9/1664A61K36/42A61K36/64A61K36/815A61K2236/331A61K2236/333A61P3/06A61P3/10A61K2300/00
Inventor 赵萍刘冰罗玉全丁德杨倩倩芮文静皮文洁李沛张喆张仪君沙会宁
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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