Use of nano enzyme-based material

Abstract

The invention provides use of a nano enzyme-based material as a sound-sensitive agent in sonodynamic force. The nano enzyme-based material comprises TiO2 nano particles and Cu single atoms anchored on the TiO2 nanoparticles. Under fluorescence imaging navigation of Cu / TiO2 in vivo, the Cu atoms in a static state are reduced to Cu <1+> in an activated state by activating electrons (e<->) on a surface of a TiO2 substrate through ultrasonic irradiation, H2O2 occupies binding sites of the Cu single atoms when the TiO2 substrate is exposed in a tumor microenvironment of over-expression H2O2, such that a catalytic performance induced by the Cu <1+> is enhanced and precise treatment is realized in cooperation with SDT. The Cu / TiO2 has high-catalytic-activity monatomic nano-enzyme characteristics while realizing molecular imaging diagnosis, such that a catalytic activity is greatly improved. A novel, efficient, small-side-effect and visualized diagnosis and precise treatment integrated novel treatment mode is provided for patients with breast cancer.

Description

technical field [0001] The invention belongs to the technical field of sound sensitizers, and in particular relates to the application of a nano-enzyme-based material. Background technique [0002] With the rapid development of nanoscience and nanotechnology, due to the full exposure of atomically active metal centers, single-atom nanozymes have good catalytic efficiency, maximum utilization of metal atoms, high activity and good recycling performance, and have attracted a lot of research scholars. s concern. Nanozymes have been widely used to treat reactive oxygen species (ROS)-related diseases, but as a major challenge, the exploration of catalytic activity for clinical applications is still in progress. [0003] Yan and his team developed a nanozyme-based single-atom catalytic bandage Pt / CeO 2 , for non-invasive treatment of neurotrauma, the nanozyme bandage can protect neurons by scavenging ROS and reducing inflammation in neuronal systems after traumatic brain injury....

AI Technical Summary

Problems solved by technology

Not only the preparation cost is high, the difficulty is high, and the stability is poor, but also it is degraded into toxic organic substances in vivo, which seriously induces potential stability and biotoxicity problems, thus limiting the clinical application in vivo

When the active surface of the nanozyme is covered by nanoparticles, it may lose its catalytic activity

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