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Novel cutibacterium granulosum strain, and composition comprising such strain or culture thereof for preventing or treating acne

A technology of propionic acid bacteria and culture, applied in the field of new strains and their cultures, can solve the problem that the etiology of AD is not very clear, and achieve the effect of improving atopic dermatitis and acne, and reducing skin inflammation

Pending Publication Date: 2021-05-07
GENOME & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although much research has been done on AD recently, the etiology of AD was not well understood until now

Method used

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  • Novel cutibacterium granulosum strain, and composition comprising such strain or culture thereof for preventing or treating acne
  • Novel cutibacterium granulosum strain, and composition comprising such strain or culture thereof for preventing or treating acne
  • Novel cutibacterium granulosum strain, and composition comprising such strain or culture thereof for preventing or treating acne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] [Example 1] Isolation and Identification of Granular Propionibacterium GENSC02

[0072] 1-1. Isolation of bacterial strains

[0073] Bacterial isolation from the skin was performed on adults who had never had skin diseases such as atopic dermatosis, psoriasis, or acne, or had no history of treatment related to these diseases within the past 6 months. To collect skin samples, the unwashed cheeks and alars of the nose were swabbed vigorously with a cotton swab moistened with sterile water. The swabs were sealed directly in tubes containing enhanced Clostridium medium (RCM), and the tubes were filled with nitrogen and incubated at 37°C for 48 to 72 hours. The culture medium of the test tube containing the culture swab was collected with a platinum ring and spread on the RCM agar plate, and this operation was repeated 3 to 4 times to isolate pure colonies.

[0074] 1-2. Identification of bacterial strains

[0075] 1) Biochemical identification using API kit

[0076] As ...

Embodiment 2

[0089] [Example 2] Hemolysis Test of Granular Propionibacterium GENSC02

[0090] Quite a number of P. granulosa strains have hemolytic toxicity and different strains are harmful to the human system in different degrees. In order to confirm the safety of Propionibacterium granulosa GENSC02, the presence or absence of hemolytic toxicity was confirmed. Granular Propionibacterium GENSC02 cultured purely in liquid medium was collected by platinum ring and plated on blood agar plates (sheep blood agar) and cultured anaerobically at 37° C. for 48 hours. Hemolyticity is determined by the presence or absence of a transparent ring around the cells, and if figure 2 As can be seen in , it was determined that Propionibacterium granulosa GENSC02 does not have hemolysis for sheep blood, and therefore is harmless to humans.

Embodiment 3

[0091] [Example 3] For the growth inhibition of Staphylococcus aureus KCTC 1621 and Propionibacterium acnes ATCC 6919 (coverage transparent zone measurement)

[0092] The growth inhibitory effect on Staphylococcus aureus and Propionibacterium acnes was confirmed by observing the formation of clear zone. When these bacteria are inoculated on an agar medium, the bacteria grow in a light color so that the color of the medium becomes cloudy, and if the bacteria do not grow, the medium appears transparent. During the experiment, if Propionibacterium granulosa GENSC02 has the effect of inhibiting bacterial growth, it is expected that Staphylococcus aureus and P. acnes will not grow around Propionibacterium granulosa GENSC02, so the culture medium becomes transparent. The granule Propionibacterium GENSC02 broth was collected using a platinum ring and a line of about 2.5 cm was drawn on a thin RCM agar plate, followed by anaerobic culture at 37° C. for 72 hours. After confirming the ...

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Abstract

The present invention relates to a Cutibacterium granulosum GENSC02 strain (KCTC 13597BP). The present invention also relates to a composition comprising the strain or a culture thereof and a use thereof. The present invention is effective for alleviating, preventing, or treating acne, atopy dermatitis, or fine dust-induced dermal inflammation.

Description

technical field [0001] This application claims priority from Korean Patent Application No. 10-2018-0098880 filed on August 23, 2018, and the entire contents disclosed in the specification and drawings of this application are incorporated herein by reference. The present invention relates to novel strains and cultures thereof which are newly isolated, identified and evaluated for efficacy. In addition, the present invention relates to compositions comprising the new strain or a culture thereof. More specifically, the present invention relates to a cosmetic composition comprising novel strains or cultures thereof having various effects such as skin-improving effects including acne-improving effects. Background technique [0002] When skin damage is caused by physical stimulation or chemicals, bacteria, and the like, an inflammatory response in the skin begins to defend against the skin damage, and various immune cells and inflammatory cytokines are involved. IL-6 (Interleuki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K8/99A61K35/74A61P17/00A61P17/10A61Q19/00C12R1/01
CPCA61P17/10C12N1/205C12R2001/01A61K35/74A61P31/04A61P29/00A61Q17/00A61Q19/00A61K8/99A61P17/00A61Q19/007C12N1/20A61K35/741
Inventor 朴汉洙
Owner GENOME & CO
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