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A kind of florfenicol powder and preparation method thereof

A technology of florfenicol and mixture, which is applied in the field of florfenicol powder and its preparation, can solve the problem of not paying attention to the stability of florfenicol soluble powder, etc., and achieves improved palatability, reduced usage, and high yield. Effect

Active Publication Date: 2021-10-12
GUANGZHOU HESHENGTANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the application also did not pay attention to the stability of florfenicol soluble powder

Method used

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  • A kind of florfenicol powder and preparation method thereof
  • A kind of florfenicol powder and preparation method thereof
  • A kind of florfenicol powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 A kind of 20% Florfenicol powder and preparation method thereof

[0045]The following components are included by weight percentage: Florfenicol 20%, sulfobutyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin (mass ratio is 3:1) 40%, hydroxypropyl methyl Cellulose 10%, pantothenic acid and vitamin B12 (mass ratio is 3:1) 2%, polyethylene glycol 200 and polyethylene glycol 600 (mass ratio is 4:1) 8%, anhydrous glucose and calcium carbonate (mass ratio Ratio 7:1) 20%.

[0046] The preparation method of described 20% Florfenicol powder comprises the following steps:

[0047] 1) Weigh the florfenicol and the inclusion agent in the formula content, add the florfenicol and the inclusion agent to the water at 75°C in sequence, and use the inclusion technique, stir until most of them are dissolved to obtain the mixture A;

[0048] 2) Continue to add the solubilizer, stabilizer and dispersant of the formulation amount to the mixture A obtained in step 1), keep stir...

Embodiment 2

[0050] Embodiment 2 A kind of 20% Florfenicol powder and preparation method thereof

[0051] Include the following components by weight percentage: Florfenicol 20%, sulfobutyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin (mass ratio is 4:1) 60%, hydroxypropyl methyl Cellulose 6%, pantothenic acid and vitamin B12 (mass ratio is 4:1) 1%, polyethylene glycol 200 and polyethylene glycol 600 (mass ratio is 5:1) 3%, anhydrous glucose and calcium carbonate (mass ratio Ratio 9:1) 10%.

[0052] The preparation method of described 20% Florfenicol powder comprises the following steps:

[0053] 1) Weigh the florfenicol and the inclusion agent in the formula content, add the florfenicol and the inclusion agent to the water at 90°C in sequence, use the inclusion technique, stir until most of them are dissolved, and obtain the mixture A;

[0054] 2) Continue to add the solubilizer, stabilizer and dispersant of the formulation amount to the mixture A obtained in step 1), keep stirring fo...

Embodiment 3

[0056] Embodiment 3 A kind of 20% Florfenicol powder and preparation method thereof

[0057] The following components are included by weight percentage: Florfenicol 20%, sulfobutyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin (mass ratio is 2:1) 54%, hydroxypropyl methyl Cellulose 9%, pantothenic acid and vitamin B12 (mass ratio is 2:1) 1.5%, polyethylene glycol 200 and polyethylene glycol 600 (mass ratio is 6:1) 7%, anhydrous glucose and calcium carbonate (mass ratio Ratio 9:1) 8.5%.

[0058] The preparation method of described 20% Florfenicol powder comprises the following steps:

[0059] 1) Weigh the florfenicol and the inclusion agent in the formula content, add the florfenicol and the inclusion agent to the water at 80°C in sequence, and use the inclusion technique, stir until most of them are dissolved to obtain the mixture A;

[0060] 2) Continue to add the solubilizer, stabilizer and dispersant of the formulation amount to the mixture A obtained in step 1), keep s...

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Abstract

The invention discloses a florfenicol powder and a preparation method thereof, belonging to the field of veterinary medicine preparations. The described Florfenicol powder comprises the following components by weight percentage: 20% Florfenicol, 40%-70% inclusion agent, 5%-10% dispersant, 1-2% stabilizer, 3-3% solubilizer 8% and filler 8‑20%; adding pantothenic acid and vitamin B12 mixture in the components as a stabilizer improves the stability of Florfenicol powder, controlling the mass ratio of dispersant and stabilizer, free fluorobenzene Nicol is highly dispersed in the dispersant, so that it can be completely dissolved, greatly improving the solubility of Florfenicol while prolonging the drug release rate and prolonging the action time of the drug; the centrifugal spray drying technology used in the preparation process is low in cost, By controlling the inlet air temperature and sieving particle size, the product yield is high, the product particle size gap is small, there is basically no dust, and the material does not stick to the wall.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a florfenicol powder and a preparation method thereof. Background technique [0002] Florfenicol (florfenicol, FF), also known as florfenicol and fluprofen, is a white or off-white crystalline powder, odorless, and bitter in taste. Molecular formula is C 12 h 14 Cl 2 FNO 4 S, the chemical structural formula is: [0003] [0004] Florfenicol is a new generation of chloramphenicol-type veterinary-specific broad-spectrum antibiotics developed in the late 1980s. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, high efficiency and safety, and is effective against poultry bacteria caused by sensitive bacteria. The effect of disease treatment is remarkable, and it has effects on both Gram-positive bacteria and negative bacteria. Because chloramphenicol has serious adverse reactions of aplastic anemia, it has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/69A61K47/38A61K47/22A61K47/10A61K47/26A61K47/02A61K47/18A61P31/04
CPCA61K9/145A61K9/146A61K31/165A61K47/6951A61P31/04
Inventor 高平陈振威李云梁金兰刘为和
Owner GUANGZHOU HESHENGTANG ANIMAL PHARMA
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