Tannic acid cross-linked chitosan/gelatin liquid-absorbing hemostatic antibacterial sponge and preparation method thereof

Abstract

The invention belongs to the technical field of functional materials, and discloses tannic acid cross-linked chitosan gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof. The preparation method comprises the steps: carrying out chemical cross-linking on chitosan and gelatin through an esterification reaction to form a primary cross-linking network, and thus obtaining modified super-hydrophilic gelatin; taking tannic acid as a cross-linking agent, and further cross-linking under the action of a strong oxidant to form a secondary cross-linked network; and then adding medical auxiliary materials, hydroxyapatite and sodium alginate to carry out physical mechanical foaming, and carrying out freeze drying to obtain the porous spongy chitosan / gelatin liquid-absorbing hemostatic antibacterial sponge. The spongy porous material obtained by crosslinking tannic acid with chitosan / gelatin is good in mechanical property, porous and fine in structure, soft in surface, wide in raw material source, low in market price, good in biocompatibility, non-toxic and biodegradable, and does not need to be infiltrated in advance when being in contact with a human body; and the preparation method is simple and efficient, is beneficial to large-scale production and has a good market application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a tannic acid cross-linked chitosan gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof. Background technique [0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above-mentioned dressings usually have the following disadvantages: medical absorbent cotton or fiber contains fiber filaments and fiber heads , the surgical field of view is often affected due to fiber shedding during surgery, and it is not conducive to wound healing; the biocompatibility of acetalized sponge is poor, and the aldehyde crosslinking agents such as glutaraldehyde and formaldehyde used in the manufacturing process have a large Biological toxicity, easy to residue, serious environmental ...

AI Technical Summary

Problems solved by technology

[0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above-mentioned dressings There are usually the following disadvantages: medical absorbent cotton or fibers contain fiber filaments and fiber heads, which often affect the surgical field of vision due to fiber shedding during surgery, and are also not conducive to wound healing; the biocompatibility of acetalized sponges is poor, and the manufacturing process uses Aldehyde crosslinking agents such as glutaraldehyde and formaldehyde have high biological toxicity and are easy to remain, causing serious environmental pollution in the production process

Although such a cross-linked structure can meet the adhesiveness of hemostatic medical tissue glue, it cannot provide the mechanical properties required for hemostatic dressings

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