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Coating method of sugar-coated tablets

A sugar-coated tablet and coating technology, which is applied in sugar-coated pills, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of unqualified products, easy fading, high-polluting tablets, etc., so as to reduce dosage and consumption, reduce Environmental pollution, the effect of reducing the coating time

Active Publication Date: 2021-04-13
重庆市药研院制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In this regard, those skilled in the art have also carried out a lot of research, such as using aluminum color lake instead, but aluminum color lake contains aluminum, although the amount is not large, it is generally recognized as safe, but for long-term users, it will still cause certain problems. Influence
Some take the method of directly adding the mucilage to the coating solution. Although this method has some merits, the sugar-coated tablet needs to be wrapped in dozens of layers. Adding the mucilage to the coating solution will increase the difficulty of coating, and it will It directly affects the disintegration time limit of the tablet, and if the disintegration is unqualified, it directly affects the curative effect of the product, and the product is also unqualified
[0006] Therefore, the coating method in the prior art also has the problems of low production process efficiency, high pollution, and easy fading and moisture absorption of the produced tablets.

Method used

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  • Coating method of sugar-coated tablets
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The first step, the package isolation layer:

[0039] Put the tablets into the coating pan, heat the material to 47°C, then add gelatin at 31ml / kg for plain tablets, so that the gelatin is evenly attached to the surface of each tablet, and then add 22g / kg of talcum powder for plain tablets to make the talc The powder can be evenly attached to the surface of each tablet. Finally, after all the tablets are scattered, blow hot air on the tablets in the coating pan for 2 minutes, so that each tablet is fully dried and covered with a layer of isolation layer, repeat the above operation 2 times until each tablet is completely wrapped with no nudity.

[0040] The amount of the plain tablet is the ratio of the material to the pure tablet (tablet without coating). The amount of gelatin is 25ml / kg for the plain tablet, which means 25ml of gelatin for 1kg of the plain tablet. The purpose of the isolation layer is to isolate the drug from the outside world, and prevent the moistur...

Embodiment 2

[0059] The first step, the package isolation layer:

[0060] Put the tablet into the coating pan, heat the material to 50°C, then add gelatin according to the amount of 40ml / kg of plain tablet, so that the gelatin is evenly attached to the surface of each tablet, and then add 25g / kg of talcum powder in the amount of plain tablet, so that Talcum powder can be evenly attached to the surface of each tablet. Finally, after all the tablets are scattered, blow hot air on the tablets in the coating pan for 4 minutes to make each tablet fully dry and wrap a layer of isolation layer. Repeat the above steps. Operate 3 times.

[0061] The second step is to pack the powder coating layer:

[0062] After controlling the temperature of the material at 45°C, add the mixed slurry according to the amount of 30ml / kg of plain tablets, so that the mixed slurry can be evenly attached to the surface of each tablet, and add 13g / kg of talcum powder in the amount of plain tablets, and also make the ta...

Embodiment 3

[0077] The first step, the package isolation layer:

[0078] Put the tablets into the coating pan, heat the material to 54°C, then add gelatin at 43ml / kg for plain tablets, so that the gelatin is evenly attached to the surface of each tablet, and then add 28g / kg of talcum powder for plain tablets, so that Talcum powder can be evenly attached to the surface of each tablet. Finally, after all the tablets are scattered, blow hot air on the tablets in the coating pan for 4 minutes to make each tablet fully dry and wrap a layer of isolation layer. Repeat the above steps. Operate 4 times.

[0079] The second step is to pack the powder coating layer:

[0080] After controlling the temperature of the material at 48°C, add the mixed slurry according to the amount of 35ml / kg of the plain tablet, so that the mixed slurry can be evenly attached to the surface of each tablet, and add an appropriate amount of talcum powder in the amount of 17g / kg of the plain tablet, and also make the talc...

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Abstract

The embodiment of the invention provides a coating method of sugar-coated tablets. The coating method comprises the following steps: step 1, coating an isolation layer; step 2, coating a powder coat layer: controlling the temperature to be 40-50 DEG C, adding mixed slurry according to the amount of 20-40 ml / kg of plain tablets, and enabling the mixed slurry to be uniformly attached to the surface of each tablet; adding a small amount of talcum powder to enable the talcum powder to be uniformly attached to the surface of each tablet, blowing hot air for 2-5 minutes after all the tablets are scattered, coating the next powder coat layer after full drying, and repeating the operation for 5-15 times until edges and corners of all the tablets disappear; step 3, coating a sugar coating layer; step 4, coating a colored layer; and step 5, polishing: scattering 2 / 3 of a part of Chinese insect wax powder into the tablets, slowly scattering the rest 1 / 3 of Chinese insect wax powder after the surfaces of the Chinese insect wax powder are bright, and rotating a coating pan until the surfaces of all the tablets are bright. The method is high in efficiency and low in pollution in the manufacturing process, and the manufactured tablets are not prone to color fading and moisture absorption.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a method for coating sugar-coated tablets. Background technique [0002] Sugar coating is a layer of sugar wrapped on medicine or food. Its functions are as follows: 1. Sugar coating can protect against light, moisture and air to a certain extent; 2. Cover up the bad smell of medicine; 3. Improve the appearance and make it easier to swallow. [0003] Coating steps of traditional sugar-coated tablets: isolation layer (3-5 layers) for 30 minutes, powder-coated layer (15-18 layers) for 20-30 minutes, sugar-coated layer (10-15 layers) for 15-20 minutes, colored sugar-coated layer (8-15 layers) ) 15 ~ 20min, lighting. In the traditional coating method, the operation of coating the powder coating layer is: sprinkle the slurry once, sprinkle the powder once, rely on the syrup attached to the tablet to adhere to the talcum powder, and repeat the operation 15 to 18 times after drying until the ed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/42A61K47/02A61K47/26A61J3/00
CPCA61K9/2893A61K9/2813A61K9/2826A61K9/2873A61J3/005
Inventor 赵建权陶兴成王钧郭平牯王学政
Owner 重庆市药研院制药有限公司
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