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Food compositions and pharmaceutical compositions containing Filipendula glaberrima extract

A technology of Mosquito grass and extract, which is applied in the fields of food compositions and pharmaceutical compositions containing Mosquito chinensis extract, and can solve problems such as side effects and the like

Pending Publication Date: 2021-04-13
KOREA INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, statins are known to cause side effects in the central nervous system, among other

Method used

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  • Food compositions and pharmaceutical compositions containing Filipendula glaberrima extract
  • Food compositions and pharmaceutical compositions containing Filipendula glaberrima extract
  • Food compositions and pharmaceutical compositions containing Filipendula glaberrima extract

Examples

Experimental program
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preparation example Construction

[0077] Each step of the method for preparing the Mosquito japonica extract and its extraction parts according to the present invention will be described in detail below.

[0078]Add 0.1-5 L, preferably 0.5-1.0 L of extraction solvent per kg of Mosquito japonica, and let it stand at room temperature for 4 to 5 days. This extraction may be performed 1 to 5 times, or may be performed a plurality of times if necessary. In addition, the temperature at the time of extraction is preferably 10°C-100°C, more preferably room temperature, but not limited thereto. The extraction time is preferably 1 to 7 days, more preferably 3 to 7 days, but not limited thereto. The obtained extract was filtered, concentrated under reduced pressure, and dried to obtain a solvent extract. The vacuum concentration is preferably performed using a vacuum rotary evaporator, but is not limited thereto. In addition, drying may be performed using one selected from reduced pressure drying, vacuum drying, boili...

Embodiment 1

[0138] The extract of embodiment 1 maple leaf mosquito grass leaf or the preparation of extraction part

[0139] 6 L of methanol was added to the collected leaves (dry weight 840 g) of Mosquito japonica, and extraction was performed at room temperature for one week. After repeating this process three times, the resulting product was filtered and concentrated to dryness at 40° C. with a rotary concentrator to obtain 194.6 g of methanol extract. The methanol extract was suspended in 2,000 mL of water, and then extracted with dichloromethane (2,000 ml×3). The aqueous layer was extracted with ethyl acetate (2,000 mL×3) to obtain ethyl acetate extraction fractions. Then, the aqueous layer was extracted again with butanol (2,000 mL×3) to obtain butanol-extracted sites.

Embodiment 2

[0140] The extract of embodiment 2 maple leaf Mosquito grass stem or the preparation of extraction part

[0141]2 L of methanol was added to the collected stems (dry weight 300 g) of Mosquito japonica, and extraction was performed at room temperature for one week. After repeating this process three times, the resulting product was filtered and concentrated to dryness with a rotary concentrator at 40°C to obtain 42.13 g of methanol extract. The methanol extract was suspended in 400 mL of water, then extracted with dichloromethane (400 mL×3). The aqueous layer was extracted with ethyl acetate (400 mL×3) to obtain ethyl acetate extraction fractions. Then, the aqueous layer was extracted again with butanol (400 mL×3) to obtain butanol-extracted fractions.

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Abstract

The invention discloses a Filipendula glaberrima alcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from a Filipendula glaberrima ethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, the Filipendula glaberrima alcoholic extract and the solvent fractions or the novel compounds 1 and 2.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119(a) to Korean Patent Application No. 10-2019-0125191 filed on October 10, 2019, the entire contents of which are hereby incorporated by reference. technical field [0003] The present invention relates to a method for preparing food composition and therapeutic pharmaceutical composition containing Mosquito japonica extract for lowering blood cholesterol level and improving atherosclerosis. Background technique [0004] Cholesterol exists in every part of the human body, including the brain, nerves, muscles, skin, liver, intestines, heart, etc., and is an essential substance involved in various biochemical reactions as a component of cell membranes in the body. However, excess cholesterol may accumulate in vascular endothelial cells or endothelium, leading to vascular diseases (such as hyperlipidemia), which can lead to secondary diseases (such as arteriosclerosis, hy...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23P10/20A23L2/52A23L7/109A21D13/06A21D2/36A23C9/152A23L7/117A61K36/73A61K31/704A61K31/7032A61P9/00A61P3/06A61P9/10A61P39/06
CPCA23L33/105A23P10/20A23L2/52A23L7/109A21D13/06A21D2/36A23C9/152A23L7/117A61K36/73A61K31/704A61K31/7032A61P9/00A61P3/06A61P9/10A61P39/06A23V2002/00A23V2200/326A23V2200/3262A23V2250/21A61K2300/00C07H15/24A61K9/2027A61K9/2018A61K9/2059A61K9/1623A61K9/1635A61K9/4866A61K9/4858A61K9/0019A61K9/0095A61K2236/333A61K31/7048C07H9/02C07J63/008A61K9/0056
Inventor 金亨子秦昶培李显范崔贤洙赵柔彬
Owner KOREA INST OF SCI & TECH
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