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AIE probe as well as preparation method and application thereof

A probe and group technology, applied in the field of AIE probes and their preparation, can solve the problems of difficult spermine, expensive analytical instruments, lack of ultraviolet absorption or fluorescence emission properties, etc., and achieve strong selectivity and ensure accuracy. Effect

Active Publication Date: 2021-04-06
中山蔚蓝医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the mainstream techniques for the quantitative detection of spermine include capillary electrophoresis, chromatography combined with mass spectrometry, etc. Although this type of method can accurately carry out the quantitative analysis of spermine, the analytical instruments are expensive and the operation process is cumbersome, which limits its application to a certain extent. Wide application of clinical quantitative analysis of spermine in urine
At the same time, since spermine itself does not have a chromophore, is not sensitive to light, and does not have ultraviolet absorption or fluorescence properties, it is difficult to detect spermine by optical methods alone. Therefore, the development of a highly sensitive quantitative method for spermine in urine The detection method is of great significance for human disease diagnosis and health monitoring

Method used

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  • AIE probe as well as preparation method and application thereof
  • AIE probe as well as preparation method and application thereof
  • AIE probe as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0032] A kind of AIE probe, described AIE probe is the compound with following structural formula:

[0033]

[0034] The preparation method of above-mentioned AIE probe comprises the following steps:

[0035] (1) At room temperature, 4-(1,2,2-triphenylethenyl)phenol (0.375g) was added to a suspension of 15mL of methanol, and after 10 minutes, 0.12g of potassium methylate was slowly added, and after stirring, mixture A;

[0036] (2) Dissolve 1,3-propane sultone (0.15 g) in 5 ml of methanol at room temperature, and stir to obtain mixture B;

[0037] (3) Add mixture B to mixture A at room temperature, stir for 12 hours until a solid appears, filter and wash with ethanol to obtain the AIE probe.

Embodiment 2

[0039] A kind of AIE probe, described AIE probe is the compound with following structural formula:

[0040]

[0041] The preparation method of above-mentioned AIE probe comprises the following steps:

[0042] (1) At room temperature, 4-(1,2,2-triphenylethenyl)phenol (0.56g) was added to a suspension of 25mL methanol, and after 15 minutes, 0.08g of sodium methoxide was slowly added, and after stirring, mixture A;

[0043] (2) Dissolve 1,3-propane sultone (0.16g) in 10ml of methanol at room temperature, and stir to obtain mixture B;

[0044] (3) Add mixture B to mixture A at room temperature, stir for 15 hours until a solid appears, filter and wash with acetone to obtain the AIE probe.

Embodiment 3

[0046] A kind of AIE probe, described AIE probe is the compound with following structural formula:

[0047]

[0048] The preparation method of above-mentioned AIE probe comprises the following steps:

[0049] (1) At room temperature, 4-(1,2,2-triphenylethenyl)phenol (0.46g) was added to a suspension of 20mL of methanol, and after 15 minutes, 0.10g of sodium methoxide was slowly added and stirred to obtain mixture A;

[0050] (2) Dissolve 1,3-propane sultone (0.155 g) in 5 ml of methanol at room temperature, and stir to obtain mixture B;

[0051] (3) Add mixture B to mixture A at room temperature, stir for 12 hours until a solid appears, filter and wash with acetone to obtain the AIE probe.

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PUM

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Abstract

The invention discloses an AIE probe, which is a compound with a structural formula shown in the specification, wherein R is a sulfur-containing group. The AIE probe can quantitatively detect spermine in urine with high sensitivity.

Description

technical field [0001] The invention belongs to the technical field of biochemical detection, in particular to an AIE probe and its preparation method and application. Background technique [0002] Biological polyamines widely exist in the human body, especially in some fast-growing tissues, and play an important role in many important cell activities. Spermine, due to its positively charged properties, is easy to combine with components in cells and regulate cell physiological activities, and plays an important role in immune response, neuron regulation and some pathological events. In recent years, some studies have determined that spermine in urine can be used as a potential biomarker of prostate cancer (PCa), and its level can reflect the risk of prostate cancer. [0003] At present, the mainstream techniques for the quantitative detection of spermine include capillary electrophoresis, chromatography combined with mass spectrometry, etc. Although this type of method can...

Claims

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Application Information

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IPC IPC(8): C07C309/11C07C303/32C09K11/06G01N21/64
CPCC07C309/11C07C303/32C07C37/66C09K11/06G01N21/6428C09K2211/1007G01N2021/6439C07C39/235
Inventor 冯昕颢何嘉乐
Owner 中山蔚蓝医疗器械有限公司
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