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Aminomethylbenzoic acid lyophilized preparation

A technology of aminomethylbenzoic acid and medicaments, which is applied in the field of aminomethylbenzoic acid freeze-dried preparations, and can solve problems such as inability to block

Active Publication Date: 2021-04-02
山东北大高科华泰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin

Method used

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  • Aminomethylbenzoic acid lyophilized preparation
  • Aminomethylbenzoic acid lyophilized preparation
  • Aminomethylbenzoic acid lyophilized preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0148] Preparation Example 1, Preparation of Powder Injection Containing Aminotoluic Acid

[0149] formula:

[0150] Aminomethylbenzoic acid 100mg, Mannitol 95 mg, Dextran-20 5 mg, pH regulator to pH4.0, Water for Injection Appropriate amount, add to 4ml.

[0151] Preparation:

[0152] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0153] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder diluted with water for inj...

preparation example 2

[0157] Preparation Example 2, Preparation of Powder Injection Containing Aminotoluic Acid

[0158] formula:

[0159]

[0160]

[0161] Preparation:

[0162] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0163] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder diluted with water for injection into a solution containing 10 mg / ml of the active ingredient, The same below), and then add water for injection to the full amount of the prescription.

[0164]...

preparation example 3

[0167] Preparation Example 3, Preparation of Powder Injection Containing Aminotoluic Acid

[0168] formula:

[0169] Aminomethylbenzoic acid 100mg, Mannitol 150mg, Dextran-40 2 mg, pH regulator to pH3.5, Water for Injection Appropriate amount, add to 5ml.

[0170] Preparation:

[0171] (1) Take the principal agent and auxiliary materials of the prescription quantity, place in a stainless steel bucket, add about 80% of the prescription quantity of water for injection, make each component dissolve, then add 0.1% (w / v) gac by the volume of the solution, Stir for 30 minutes, filter and decarburize, and add water for injection to nearly the full amount of the prescription.

[0172] (2) The filtrate is sampled, and the pH value is measured, and if necessary, it is adjusted to a specified value with a pH regulator (this specified value is the value of the measured pH value of the freeze-dried gained dry powder diluted with water for inj...

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Abstract

The present invention relates to aminomethylbenzoic acid lyophilized preparations. The invention particularly relates to a method for determining the content of aminomethylbenzoic acid in a biologicalsample of an organism. The method comprises the following steps of: providing a high performance liquid chromatography system for determination; providing a blank biological sample and a drug-containing biological sample, wherein the biological samples are collected from organisms before and after administration of an agent; preparing a test solution, and treating the drug-containing biological sample to prepare a test liquid for liquid chromatography determination; and determining the test solution and the test liquid in a high performance liquid chromatography system, and calculating the aminomethylbenzoic acid content in the biological sample according to the determination result. The invention provides a method for monitoring the concentration change of active substances in a biological sample such as blood or urine after an aminomethylbenzoic acid preparation with good performance is clinically applied into a body, and the method provides an effective basis for evaluating the treatment effect of aminomethylbenzoic acid or in-vivo behaviors of aminomethylbenzoic acid.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a hemorrhage that can be used for hemorrhage caused by excessive primary fibrinolysis, including acute and chronic, localized or systemic hyperfibrinolytic hemorrhage, which is common in cancer, leukemia, Freeze-dried powder injection pharmaceutical composition for obstetrics and gynecology accidents, severe liver disease bleeding, etc., especially relates to a freeze-dried powder injection pharmaceutical composition containing aminomethylbenzoic acid, and the present invention also relates to a reliable method for measuring biological For example, the content of the above-mentioned aminomethylbenzoic acid in biological samples such as blood, urine, etc. after the human or rat is given the above-mentioned freeze-dried powder injection pharmaceutical composition comprising aminomethylbenzoic acid, and then provides a basis for evaluating the therapeutic effect of aminomethylbenzoic ac...

Claims

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Application Information

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IPC IPC(8): G01N30/06A61K9/19A61K31/195A61K47/18A61K47/26A61P7/04
CPCG01N30/06A61K31/195A61K9/19A61K9/0019A61K47/26A61K47/183A61P7/04
Inventor 姜长通李明慧周雨汐黄楠
Owner 山东北大高科华泰制药有限公司
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