Methoxylamine mother liquor double-effect evaporation device and method in furan ammonium salt production

Abstract

The invention relates to a double-effect evaporation device and a double-effect evaporation method for methoxylamine mother liquor in furan ammonium salt production. The double-effect evaporation device is characterized by (1) preheating the methoxylamine mother liquor at 0.9-1.2 m <3> / h and 0.6-0.8 m <3> / h respectively and then pumping into a first-effect evaporator and a second-effect evaporator, (2) controlling the pressure in the first-effect evaporator and the pressure in the second-effect evaporator to be 0.07-0.09 Mpa, controlling the temperature of the first-effect evaporator to be 78-85 DEG C, and enabling a gas phase of the first-effect evaporator to enter the second-effect evaporator to be heated and evaporated, (3) condensing a gas phase from the second-effect evaporator, extracting, evaporating for 3040 minutes, and respectively extracting materials at the bottoms of the first-effect evaporator and the second-effect evaporator into a first-effect crystallization kettle anda second-effect crystallization kettle, and (4) crystallizing at 45-50 DEG C for 30-40 minutes, centrifuging to obtain white solid anhydrous sodium sulfate, and returning the centrifuged mother liquor to a double-effect evaporator for evaporation or discharging to a sewage system. The device has the advantages that the device is simple in structure and easy to operate, continuous production can be achieved, and production efficiency is improved, the utilization rate of a heat source is improved, the steam consumption is reduced from 0.9-1.1 to 0.4-0.55, the recovery efficiency of the methoxylamine mother liquor is improved from original 45%-55% to 75%-80%, and the purity of sodium sulfate is improved from original 97%-98% to 98.5%-99.5%.

Description

technical field [0001] The invention belongs to the technical field of chemical production, and relates to a double-effect evaporation device and method for methoxyamine mother liquor in the production of furan ammonium salt. Background technique [0002] Furan ammonium salt (English name: SMIA) is currently the main raw material for the production of cephalosporin antibiotics cefuroxime and cefuroxime axetil. Cefuroxime was first successfully developed by Glaxo Williams in 1978 in Britain, Ireland and Germany It was first listed in Italy and then sold in many countries and regions around the world. The product name is "Syrio", which was approved by the US FDA in 1987 and was launched in the United States. Due to its definite curative effect, it is widely used to fight against various infections caused by sensitive fungi , entered the 1990s, the drug has become the world's best-selling anti-infective drugs, with good curative effect, furan ammonium salt as a new type of phar...

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Problems solved by technology

[0004] In the industrial production of furan ammonium salt, the methoxyamine mother liquor after rectification is often used for distillation to recover sodium sulfate salt, but because the kettle evaporation uses the still jacket for heat exchange, the heat exchange area is small and the heat transfer effect is poor. The utilization efficiency of heat energy is poor and the evaporation speed is slow. Therefore, there is always high energy consumption in the process of distillation and concentration (nearly 40% of the steam cannot be effectively used), and the concentration and evaporation equipment occupies a large area, cannot be continuously automated, and the operation is labor-intensive. Problems such as incomplete material recovery

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