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Method for detecting addition of chemical components in Chinese patent medicine

A technology of chemical composition and detection method, which is applied in the field of detection of chemical composition addition in Chinese patent medicines, can solve problems such as easy interference detection, complex matrix, unsatisfactory sensitivity and accuracy, etc.

Pending Publication Date: 2021-03-19
北京美康堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the complexity of the matrix in Chinese patent medicines, ingredients such as flavonoids, alkaloids, and polysaccharides are likely to interfere with the detection. The sensitivity and accuracy of traditional Chinese medicine detection methods such as thin-layer chromatography and high-performance liquid chromatography are not ideal. Therefore, it is necessary to provide a detection method suitable for various chemical complex components

Method used

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  • Method for detecting addition of chemical components in Chinese patent medicine
  • Method for detecting addition of chemical components in Chinese patent medicine
  • Method for detecting addition of chemical components in Chinese patent medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Detection of nabumetone in Chinese patent medicine samples:

[0029] The preparation method of the standard solution is as follows: purchase the standard substance of nabumetone from the market, accurately weigh 10 mg of it in a 10 mL volumetric flask after drying, add methanol-acetonitrile (1:1, v / v) to dissolve and then constant volume , to prepare a standard solution with a chemical composition concentration of 1mg / mL, and then take the standard solution into a volumetric flask ranging from 1mL to 100mL, and prepare a standard solution of 10μg / mL.

[0030] The preparation method of the sample solution is as follows: add the sample of Chinese patent medicine to be tested and 30mL of methanol-acetonitrile (1:1) into a 50mL volumetric flask, dissolve evenly by ultrasonic and set to volume.

[0031] The determination method is as follows: Accurately draw 5-10mL of the sample solution into a volumetric flask, shake the mobile phase B to a constant volume, filter it throug...

Embodiment 2

[0044] Detection of sulfamethoxazole and trimethoprim in Chinese patent medicine samples:

[0045] The preparation method of the standard solution is as follows: buy the standard substances of sulfamethoxazole and trimethoprim in the market, after drying, take 10 mg accurately respectively in a 10 mL volumetric flask, add methanol-acetonitrile (1:1, v / v) Dilute to volume after dissolving, and prepare a standard solution with a concentration of 1mg / mL for each chemical component, and then take each standard solution into a volumetric flask ranging from 1mL to 100mL, and prepare a mixed standard solution of 10μg / mL.

[0046] The preparation method of the sample solution is as follows: add the sample of Chinese patent medicine to be tested and 30mL of methanol-acetonitrile (1:1) into a 50mL volumetric flask, dissolve evenly by ultrasonic and set to volume.

[0047] The determination method is as follows: Accurately draw 5-10mL of the sample solution into a volumetric flask, shak...

Embodiment 3

[0061] Detection of acetaminophen, ketoprofen, and benproperine phosphate in Chinese patent medicine samples:

[0062] The preparation method of standard solution is as follows: buy the standard substance of paracetamol, ketoprofen, benproperine phosphate in the market, after drying, take 10mg accurately respectively in the volumetric flask of 10mL, add methanol-acetonitrile (1 : 1, v / v) after dissolving to constant volume, and preparing a standard solution with a concentration of 1 mg / mL for each chemical component, and then taking each standard solution into a volumetric flask ranging from 1 mL to 100 mL, and preparing a mixed standard of 10 μg / mL solution.

[0063] The preparation method of the sample solution is as follows: add the sample of Chinese patent medicine to be tested and 30mL of methanol-acetonitrile (1:1) into a 50mL volumetric flask, dissolve evenly by ultrasonic and set to volume.

[0064] The determination method is as follows: Accurately draw 5-10mL of the...

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Abstract

The invention discloses a method for detecting the addition of chemical components in a Chinese patent medicine. The method comprises the steps of preparing a standard solution from chemical components to be detected, drawing a standard curve, preparing a sample solution from a Chinese patent medicine sample to be detected, determining by liquid chromatography-tandem mass spectrometry, and comparing with the standard solution to perform qualitative and quantitative analysis. By optimizing the treatment process of the sample and the standard substance and accurate chromatographic and mass spectrometric conditions, detection of multiple added functional chemical components in the Chinese patent medicine is realized, the sample can be qualitatively and quantitatively processed on a machine only by dilution and filtration treatment, the tedious steps of conventional dispersive solid-phase extraction and the like are greatly simplified, meanwhile, the detection time is relatively short, consumable consumption is low, and powerful technical support is provided for quality detection of the Chinese patent medicine.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, in particular to a detection method for adding chemical components in Chinese patent medicines. Background technique [0002] Chinese patent medicines are made of traditional Chinese medicinal materials. Under the guidance of the theory of traditional Chinese medicine, in order to prevent and treat diseases, according to the prescribed prescription and preparation process, they are processed into certain dosage forms of traditional Chinese medicine products, which are approved by the State Drug Administration Department. A class of commercialized traditional Chinese medicine preparations. Since each medicine in the prescription contains a variety of chemical components, and some chemicals are added in order to improve the efficacy of the medicine, these chemical components are the material basis for the compound prescription to exert its medicinal effect, but any ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/72
CPCG01N30/02G01N30/34G01N30/72
Inventor 王亚平杨百艳胡颖高峰杨丹丹豆环宇郑冬梅
Owner 北京美康堂医药科技有限公司
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