Method for detecting concentration of related substances in ibuprofen medicine based on ultrahigh liquid chromatography
A technique for ultra-high liquid chromatography and related substances, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., and can solve the confusion of the positioning of impurities M and ibuprofen sorbitol ester, the high cost of detection time and solvent, and the high amount of impurities. And other issues
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[0028] As previously mentioned, the present invention aims to propose a method based on ultra-high liquid chromatography to measure the concentration of related substances in ibuprofen medicine, and the related substances include C, J, M and ibuprofen sorbitol ester, the The method can realize the effective separation between the chromatographic peaks of various impurities, and can accurately identify and quantify the ibuprofen and its related impurities.
[0029] The instruments and medicines selected for use in the present invention are all carried out according to conventional conditions or conditions suggested by the manufacturer, or through commercially available conventional products, unless conditions are specified. The measuring instrument selected by the present invention is WatersACQUIYUPLC.
[0030] The impurity chemical structural formula that the present invention detects is as shown in table 1:
[0031] The list of chemical structural formulas of related substan...
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