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Composite drug-loaded fiber for absorbable surgical suture

A surgical suture and fiber technology, which is applied in the direction of surgery, fiber chemical characteristics, chemical post-treatment of synthetic polymer artificial filaments, etc., can solve the problem of insufficient strength of natural absorbable sutures, few varieties of absorbable sutures, hidden dangers of biological safety, etc. problems, to achieve excellent biocompatibility, excellent tensile properties, and good mechanical strength

Inactive Publication Date: 2021-03-19
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to alleviate the lack of varieties of existing absorbable sutures, there are some defects that are difficult to improve, such as the strength of natural absorbable sutures is not enough, it is not suitable for suturing tissues with high tension, and there is a potential risk of rejection. The biodegradation time of absorbable sutures is too long, and there are potential biological safety hazards. It is urgent to develop new varieties of sutures to make up for the defects and insufficiencies of existing surgical sutures

Method used

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  • Composite drug-loaded fiber for absorbable surgical suture
  • Composite drug-loaded fiber for absorbable surgical suture
  • Composite drug-loaded fiber for absorbable surgical suture

Examples

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Effect test

Embodiment 1

[0029] Example 1: An anti-inflammatory composite drug-loaded fiber for absorbable sutures—collagen / PLCL / graphene oxide composite drug-loaded fiber of alginic acid / carboxylated chitosan / ketoprofen coating, referred to as : SA-CCTS-KET@COL-PLCL-GO

[0030] The main material is composed of biodegradable natural biomass in vivo - type I collagen (COL) and chemically synthesized biodegradable polymer - polycaprolactone copolymer (PLCL). The reinforced and toughened material is Nano carbon material - graphene oxide (GO), the porogen is a material or agent with good biocompatibility - vitamin E acetate (VEA), curcumin (Cur), the coating material is made of sodium alginate (SA) and carboxylated chitosan (CCTS), and the anti-inflammatory drug contained in the coating material is ketoprofen (KET). The above main materials, reinforcing materials, porogens, coating materials, and anti-inflammatory drugs are compounded and combined with wet spinning, coating and in-situ generation process...

Embodiment 2

[0036] Example 2: An antibacterial composite drug-loaded fiber for absorbable sutures—collagen / PLGA / graphene oxide composite drug-loaded fiber coated with alginic acid / chloramphenicol, referred to as: SA-CAP@COL- PLGA-GO

[0037] The main material is composed of biodegradable natural biomass in vivo - type I collagen (COL) and chemically synthesized biodegradable polymer - polylactic acid copolymer (PLGA), and the reinforced and toughened material is nano-carbon material ——Graphene oxide (GO), the porogen is a material or agent with good biocompatibility—vitamin E acetate (VEA), curcumin (Cur), the coating material is made of sodium alginate (SA) , the antibacterial drug contained in the coating material is chloramphenicol (CAP). The above main materials, reinforcing materials, porogens, coating materials, and antibacterial drugs are compounded and combined with wet spinning, coating, and in-situ generation processes to prepare composite drug-loaded materials that can be used...

Embodiment 3

[0043] Example 3: An anticoagulant composite drug-loaded fiber for absorbable sutures—carboxylated chitosan / heparin-coated silk fibroin / PLGA / single-walled carbon nanotube composite drug-loaded fiber, referred to as: CCTS-UFH@Fibroin-PLGA-SWNT

[0044]The main material is composed of biodegradable natural biomass in vivo - silk fibroin (Fibroin) and chemically synthesized biodegradable polymer - polylactic acid copolymer (PLGA), and the reinforced and toughened material is nano carbon material - —Single-walled carbon nanotubes (SWNT), the porogen is a material with good biocompatibility—polyethylene glycol (PEG), and the coating material is carboxylated chitosan (CCTS). The loaded anticoagulant drug is heparin (UFH). The above main materials, reinforcing materials, porogens, coating materials, and anticoagulant drugs are compounded and combined with wet spinning, coating, and in-situ generation processes to prepare a composite material that can be used for absorbable surgical ...

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Abstract

The invention provides a composite drug-loaded fiber for an absorbable surgical suture. The existing absorbable surgical suture has few varieties and has the defects that the natural absorbable surgical suture has low strength and has the risk of generating rejection reaction, and the in-vivo degradation time of the synthesized absorbable surgical suture is too long. In order to solve the problems, the invention provides the composite drug-loaded fiber for the absorbable surgical suture, so as to make up the defects of the existing suture, avoid the pain of a patient during postoperative suture removal and reduce the infection risk. The drug-loaded fiber is prepared by compounding a main material, a reinforcing material, a pore-foaming agent, a coating material and an anti-inflammatory, antibacterial and anticoagulant drug and combining the processes of spinning, coating and the like. The fiber provided by the invention has the beneficial effects that the surface structure is uniform and smooth; the diameter is adjustable and controllable; the fiber has a porous internal structure; the fiber has good mechanical strength, extensibility, toughness and tensile property; the fiber hasexcellent biocompatibility; the fiber has more ideal in-vivo degradation time; and the fiber has good drug slow release performance, and the effects of early anti-inflammatory, antibacterial or anticoagulant of wound suture are achieved.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a composite drug-loaded fiber used for absorbable surgical sutures. Background technique [0002] Absorbable sutures are generally used for suturing intradermal soft tissues in gynecology, obstetrics, surgery, plastic surgery, urology, pediatric surgery, stomatology, ENT, ophthalmic surgery, etc. Absorbable suture is a new type of suture material that can be degraded and absorbed by the human body after being implanted in human tissue during surgical suture, and does not require stitches to be removed, eliminating the pain of stitch removal. At present, according to the degree of absorbability, it is divided into catgut, chemically synthesized polymer thread, and pure natural collagen suture. Compared with non-absorbable sutures, absorbable sutures have obvious advantages, that is, they can be absorbed and avoid the pain of removing sutures. Disadvantages are also obvious: d...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/06A61L17/10A61L17/14D01F6/92D01F1/10D01F11/08
CPCA61L17/10A61L17/12A61L17/105A61L17/06A61L17/145D01F6/92D01F1/10D01F11/08A61L2300/404A61L2300/42A61L2300/606A61L2300/602
Inventor 吴焕岭李子银林玲
Owner YANCHENG INST OF TECH
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