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Extraction method and detection method of alkaloid in coptis chinensis

An extraction method and alkaloid technology, which is applied in measuring devices, medical formulas, plant raw materials, etc., can solve the problems that the Coptis chinensis extraction method cannot meet the requirements, and achieve the convenience of subsequent analysis and precise purification, improve the purity, and increase the content of alkaloids Effect

Active Publication Date: 2021-03-19
JIANGHAN UNIVERSITY
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Problems solved by technology

The main active ingredients of Coptis chinensis are alkaloids, including berberine, epiberberine, jatrorrhizine, coptisine, palmatine, etc. Among them, berberine has the highest content, and they all belong to the quaternary ammonium type organisms with similar chemical structures. Alkali, which can only exert its medicinal effect when it needs a higher content in the refined Chinese medicine preparation, but the existing Coptis chinensis extraction method cannot meet the requirements

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  • Extraction method and detection method of alkaloid in coptis chinensis
  • Extraction method and detection method of alkaloid in coptis chinensis
  • Extraction method and detection method of alkaloid in coptis chinensis

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[0024] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0025] The embodiment of the present invention provides a method for extracting alkaloids in Coptidis Rhizoma, comprising the following steps: pulverizing Coptis Rhizoma medicinal materials, extracting in a water bath, filtering, and purifying the filtrate to obtain the alkaloids; Berberine, berberine, palmatine, and jatrorrhizine.

[0026] Specifically, after the Coptis rhizome is crushed, pass through a 20-40 mesh sieve, take 3-10 parts of the powder and put it in a stoppered measuring bottle; add 60-200 parts of low-molecular alcohol or acidic low-molecular alcohol, seal it with a stopper, and weigh it. Heat in a water bath at...

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Abstract

The invention relates to an extraction method of alkaloid in coptis chinensis. The extraction method comprises the following steps of smashing coptis chinensis medicinal materials, carrying out waterbath extraction, filtering, and purifying the filtrate by acid precipitation or column chromatography to obtain alkaloid; and the alkaloid comprises coptisine, epiberberine, berberine, palmatine and jateorhizine. According to the extraction method provided by the invention, the high-content alkaloid can be obtained, and subsequent analysis and accurate purification are facilitated.

Description

technical field [0001] The invention relates to the technical field of extracting coptis alkaloids, in particular to an extraction method and a detection method of alkaloids in coptis. Background technique [0002] Coptis chinensis is an important medicine for clearing heat and detoxifying, mainly used for damp heat and fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, upset and insomnia, vomiting of blood heat at the nose, carbuncle and furuncle, red eyes and toothache, thirst, external treatment of eczema , eczema, ear canal discharge; it mainly contains berberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride and other alkaloids, of which berberine is the main active ingredient. The main active ingredients of Coptis chinensis are alkaloids, including berberine, epiberberine, jatrorrhizine, coptisine, palmatine, etc. Among them, berberine has the highest content, and they all belong to the quaternary ammonium type organism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718G01N30/02G01N30/06G01N30/14G01N30/54G01N30/74
CPCA61K36/718G01N30/02G01N30/06G01N30/14G01N30/54G01N30/74A61K2236/331A61K2236/53A61K2236/55G01N2030/027G01N2030/062G01N2030/146Y02A50/30
Inventor 张涛陈中强曹晓琴方振峰施璐袁发浒翟莹
Owner JIANGHAN UNIVERSITY
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