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Use of isoquinoline compounds to prepare antiviral products

A technology of isoquinoline and compounds, applied in the field of animal disease prevention and control, can solve the problems of unclear antiviral mechanism, complex mechanism of action, and different ways of invading cells, and achieve good clinical application prospects and less toxic and side effects

Active Publication Date: 2022-07-22
GENIFARM LAB INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is also reported that isoquinoline alkaloids are used for antiviral infection, such as CN201510942635.8, which reports that the isoquinoline alkaloids isolated from the bark of the Dai nationality medicinal plant Leguminosae cassia (Cassia alata L.) have the effect on rotavirus Good inhibitory effect; CN201710256643.6 reports the activity of isoquinoline alkaloids on hepatitis B virus and is used for the treatment of hepatitis B; CN201110218079.1 reports the activity of isoquinoline alkaloids on human papillomavirus; CN200910063163.3 reports the activity of berberine against influenza Virus activity, etc., but due to the variety of viruses, complex mechanism of action, and different ways of invading cells, the number of studies is small, and the mechanism of anti-virus is still unclear
Typically, antimicrobials have no effect on viral infections and are not used as antiviral products

Method used

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  • Use of isoquinoline compounds to prepare antiviral products
  • Use of isoquinoline compounds to prepare antiviral products
  • Use of isoquinoline compounds to prepare antiviral products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 The effect of grandisin on pigs infected with African swine fever virus

[0067] 1. Experimental pigs: located in a farm where African swine fever has occurred in Henan Province, and selected nursery pigs that have no clinical symptoms and were confirmed to be positive for African swine fever virus by saliva sampling PCR. All pigs with clinical symptoms were culled and treated harmlessly. Take biosafety measures throughout the process.

[0068] 2. Grouping: The experimental pigs were randomly divided into the following 2 groups, with 20 pigs in each group:

[0069] (1) Experimental group: conventional feeding + Grandisin;

[0070] (2) Blank control group: conventional feeding.

[0071] 3. Treatment: Oral administration of Grandisin to experimental pigs, mode of administration: mixed drink, dose: 5 mg / kg b.w., for 30 days. The mortality was recorded every day, and the mortality of each group after 30 days was counted.

[0072] 4. The results are shown in T...

Embodiment 2

[0075] Example 2 The effect of berberine on pigs infected with African swine fever virus

[0076] 1. Experimental pigs: located in a farm where African swine fever has occurred in Jiangsu Province, select pregnant sows who have no clinical symptoms and are confirmed to be positive for African swine fever virus infection by saliva sampling PCR. All pigs with clinical symptoms were culled and treated harmlessly. Take biosafety measures throughout the process.

[0077] 2. Grouping: The experimental pigs were randomly divided into 3 groups, namely the experimental group, (10% enrofloxacin soluble powder) control group and blank control group, 50 heads in each group:

[0078] (1) Experimental group: conventional feeding + berberine;

[0079] (2) Control group: (10% enrofloxacin soluble powder);

[0080] (3) Blank control group: conventional feeding.

[0081] 3. Treatment: The experimental group was given berberine, the mode of administration: mixed feeding, the dose: 20 m...

Embodiment 3

[0086] Example 3 The effect of berberine on pigs infected with African swine fever virus

[0087] 1. Experimental pigs: located in a farm in Jiangsu Province where African swine fever has occurred, select lactating sows that have no clinical symptoms and are confirmed to be positive for African swine fever virus by saliva sampling PCR. All pigs with clinical symptoms were culled and treated harmlessly. Take biosafety measures throughout the process.

[0088] 2. Grouping: The experimental pigs were randomly divided into two groups: the experimental group and the blank control group, with 30 pigs in each group:

[0089] (1) Experimental group: conventional feeding + berberine;

[0090] (2) Blank control group: conventional feeding.

[0091] 3. Treatment: The experimental group was given berberine, the mode of administration: mixed drink, the dose: 1kg / ton of drinking water, free drinking, continuous use. The mortality was recorded every day, and the mortality of each group a...

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Abstract

The invention discloses the use of a class of isoquinoline compounds in the preparation of antiviral products. The present invention confirms through experiments that isoquinoline compounds can prevent and / or treat diseases caused by various viruses. Moreover, isoquinoline compounds also have antibacterial, anti-inflammatory, anti-platelet aggregation, and growth-promoting effects in anti-virus. The invention provides a new medicinal use of isoquinoline compounds, provides a new effective way for the prevention and / or treatment of diseases caused by virus infection, is an efficient and safe prevention and treatment method, and has excellent clinical application prospect.

Description

technical field [0001] The invention belongs to the field of animal disease prevention and treatment. In particular, it relates to the use of isoquinoline compounds or their salts in the preparation of antiviral products. Background technique [0002] Virus is a non-cellular life form. It consists of a long nucleic acid chain and a protein shell. Viruses do not have their own metabolic mechanisms and do not have an enzyme system. Therefore, the virus leaves the host cell and becomes a chemical substance without any life activity and unable to reproduce independently. Once inside the host cell, it can use the material and energy in the cell, as well as the ability to replicate, transcribe and translate, to produce a new generation of virus like it according to the genetic information contained in its own nucleic acid. Virus infection mainly includes injection invasion, endocytosis, membrane fusion or other special invasion methods. Endosomes are a compartment of the delive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P31/14A61P31/12A61P31/04A61P7/02A61P3/00
CPCA61K31/4375A61P31/14A61P31/12A61P31/04A61P7/02A61P3/00A61K2300/00Y02P20/55
Inventor 王永东操基元祝诗发张晨光程稳黄志鹏
Owner GENIFARM LAB INC
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