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Online measurement device for crystal size and shape in high-solid-content crystallization process

A technology for measuring device and crystal size, which is applied in the direction of measuring device, crystallization separation, solution crystallization, etc. It can solve the problem of difficult on-line measurement of crystal shape and size distribution, so as to reduce the influence of disturbance, realize recycling and avoid pipeline blockage. Effect

Active Publication Date: 2021-03-12
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide an on-line measurement device for crystal size and shape in the crystallization process with high solid content, so as to solve the above-mentioned problems in the prior art, and to effectively solve the difficulty in realizing the crystal shape and size distribution in the industrial crystallization process due to excessive crystal content Problems that are difficult to measure online

Method used

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  • Online measurement device for crystal size and shape in high-solid-content crystallization process
  • Online measurement device for crystal size and shape in high-solid-content crystallization process
  • Online measurement device for crystal size and shape in high-solid-content crystallization process

Examples

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Effect test

Embodiment 1

[0053] Example 1 L-glutamic acid-water batch cooling crystallization process, crystallization solution 3L in 4L crystallization tank, solution temperature 50°C, stirring speed 250rpm, average crystal size 80-150μm, solid content 10%. The peristaltic pump adopts Masterflex L / S, the pipeline is latex tube, the inner diameter is 3.2mm, and the wall thickness is 1.6mm; it is kept insulated by insulation cotton; the solution amplifier is made of glass material with good light transmission, the constant temperature tank is made of glass material, and the heating solution is water. Keep at 52°C; the online image system camera and light source are respectively placed in the solution amplifier on both sides of the constant temperature bath, and the light source and camera focus on the solution amplifier. Adjust the definition of the image system, and control the flow rate of the crystal in the solution through the peristaltic pump, the process is about 100rpm; collect the image of the c...

Embodiment 2

[0054] Example 2 L-glutamic acid-water batch cooling crystallization process, crystallization solution 7L in 10L crystallization tank, solution temperature 50°C, stirring speed 150rpm, average crystal size 150-200μm, solid content 20%. The peristaltic pump adopts Masterflex L / S, the pipeline is latex tube, the inner diameter is 4.8mm, and the wall thickness is 1.6mm; the insulation cotton is used to keep the heat; the solution amplifier is made of glass material with good light transmission, the constant temperature tank is made of glass material, and the heating solution is water. Keep at 52°C; the online image system camera and light source are respectively placed in the solution amplifier on both sides of the constant temperature bath, and the light source and camera focus on the solution amplifier. Adjust the definition of the image system, and control the flow rate of the crystal in the solution through the peristaltic pump, the process is about 100rpm; collect the image o...

Embodiment 3

[0055] Example 3 Potassium dihydrogen phosphate (KDP) batch cooling crystallization process, crystallization solution 3L in 4L crystallization kettle, solution temperature 50 ℃, stirring speed 250rpm, average crystal size 100-200μm, solid content 15%. The peristaltic pump adopts Masterflex L / S, the pipeline is latex tube, the inner diameter is 3.2mm, and the wall thickness is 1.6mm; it is kept insulated by insulation cotton; the solution amplifier is made of glass material with good light transmission, the constant temperature tank is made of glass material, and the heating solution is water. Keep at 51°C; the camera and light source of the online image system are respectively placed in the solution amplifier on both sides of the constant temperature bath, and the light source and camera focus on the solution amplifier. Adjust the definition of the image system, and control the flow rate of the crystal in the solution through the peristaltic pump, the process is about 100rpm; c...

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Abstract

The invention discloses an online measurement device for the size and shape of a crystal in a high-solid-content crystallization process. The online measurement device comprises a solution amplifier,a measurement device, a peristaltic pump, a crystallization kettle, a dilution device and a liquid storage tank, a crystal-containing solution is arranged in the crystallization kettle; the inner wallof the solution amplifier is smooth, one end is an amplification end, and the other end is a contraction end; the contraction end of the solution amplifier is communicated with one end of the liquidstorage tank and one end of the crystallization kettle; the amplification end of the solution amplifier is respectively communicated with the dilution device and the peristaltic pump; the peristalticpump is communicated with the other end of the crystallization kettle; the solution amplifier, the peristaltic pump and the crystallization kettle form a complete passage through a pipeline; a measuring instrument of the measuring device is arranged in the outer side of the solution amplifier and focuses on the solution in the amplification end of the solution amplifier; and at least one stop valve is mounted on each branch of the pipeline. According to the invention, measurement of a crystalline solution with solid content higher than 10% is realized; and the pipeline heat preservation and constant-temperature tank is designed, so that the problems of solution crystallization on the pipe wall and pipeline blockage are avoided.

Description

technical field [0001] The invention relates to the technical field of on-line measurement of industrial crystallization, in particular to an on-line measurement device for crystal size and shape during crystallization with high solid content. Background technique [0002] As an important means of separation and purification, crystallization technology is widely used in pharmaceutical, chemical, food and other industries (Z.Gao, et al.Engineering, 2017.3:343-353; H.Lorenz, et al.Chem.Eng.Technol., 2017.40:1210). The existing methods for measuring the shape and size distribution of the crystallization process mainly include FBRM, laser particle size analyzer, ultrasonic method and image method, wherein the crystal shape mainly adopts the online image method (Xue Z.Wang, Crystal growth measurement using 2D and 3D imaging and the perspectives for shapecontrol. Chemical Engineering Science. 2008). However, the literature (Nagy et.al., Recent advances in the monitoring, modelin...

Claims

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Application Information

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IPC IPC(8): G01N15/02G01N21/84B01D9/02
CPCG01N15/02G01N15/0205G01N15/0227G01N21/84B01D9/00G01N2015/0294G01N2021/8477B01D9/0013B01D9/0059B01D9/0077B01D9/0063G01N2015/1493G01N2015/1497G01N15/1433B01D2009/0086G01N15/1404G01N15/1434
Inventor 张方坤艾自东吴兵单宝明
Owner QINGDAO UNIV OF SCI & TECH
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