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Application of baicalin in preparation of medicine for preventing and/or treating asymptomatic hyperuricemia and/or uric acid nephropathy

A technology for uric acid nephropathy and hyperuricemia, applied in the field of biomedicine, can solve the problems of high toxicity and side effects of uric acid nephropathy drugs, poor tolerance of patients, and clinical use restrictions

Inactive Publication Date: 2021-03-09
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention intends to solve the characteristics of existing drugs for the treatment of uric acid nephropathy, which have large toxic and side effects, are not easily tolerated by patients, and are limited in clinical use.

Method used

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  • Application of baicalin in preparation of medicine for preventing and/or treating asymptomatic hyperuricemia and/or uric acid nephropathy
  • Application of baicalin in preparation of medicine for preventing and/or treating asymptomatic hyperuricemia and/or uric acid nephropathy
  • Application of baicalin in preparation of medicine for preventing and/or treating asymptomatic hyperuricemia and/or uric acid nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] The following examples adopt the methods of animal and cell experiments for research.

[0021] 1. Study on the effect of baicalin on uric acid nephropathy in mice

[0022] 1.1 Materials

[0023] 1.1.1 Experimental animals

[0024] Male Kunming mice of SPF grade, weighing 20-22 g, were provided by Spifford (Beijing) Biotechnology Co., Ltd., animal certificate: SCXK (Beijing) 20119-0010.

[0025] 1.1.2 Drugs and reagents

[0026] Baicalin (purity>90%), batch number: C031B150902, purchased from Sichuan Xieli Pharmaceutical Co., Ltd.; allopurinol (purity 98%), batch number: Y27O8C46913, purchased from Shanghai Yuanye Biotechnology Co., Ltd.; oxonic acid potassium salt ( Purity>98%), batch number: P137112, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; uric acid assay kit (uricase colorimetric method), batch number: 20191129; urea nitrogen kit (urease method), batch number: 20191211; Creatinine kit (creatinine oxidase method), batch number: 20191218; C...

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Abstract

The invention belongs to the field of biological medicines, and relates to an application of baicalin in preparation of a medicine for preventing and / or treating asymptomatic hyperuricemia and / or uricacid nephropathy. Based on animal and cell experiments, the effect of baicalin on hyperuricemia nephropathy is studied, and the result shows that baicalin can inhibit the activity of xanthine oxidase, inhibit uric acid generation, reduce the serum uric acid level of mice with uric acid nephropathy and remarkably improve the renal function of the mice. The baicalin inhibits damage of sodium uratecrystals to rat renal tubular epithelial cells by reducing secretion of TNF alpha, IL-1beta, lactate dehydrogenase and NO.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of baicalin in the preparation of medicines for preventing and / or treating asymptomatic hyperuricemia and / or uric acid nephropathy. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of asymptomatic hyperuricemia and uric acid nephropathy has increased significantly. About 2 / 3 of the uric acid produced by the human body is excreted with the urine through the kidneys. Therefore, hyperuricemia can lead to a decline in renal function. Uric acid nephropathy refers to the short-term deposition of a large number of urate crystals in the renal collecting duct, renal pelvis, and ureter and block the renal tubules, causing proximal expansion of the renal tubules, resulting in acute and severe damage to renal function, causing acute renal failure, or Long-term high serum uri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/519A61P19/06A61P13/12A61P13/04
CPCA61K31/519A61K31/7048A61P13/04A61P13/12A61P19/06A61K2300/00
Inventor 徐凌云邱银生刘永杰向慧龙
Owner WUHAN POLYTECHNIC UNIVERSITY
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