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Echinacoside preparation and preparation method thereof

A technology for echinacoside and preparations, which is applied in the field of echinacoside preparations and its preparation, can solve the problems of low tablet hardness, easy bonding, and large amount of ingredients, and achieve qualified friability, smooth surface, and high hardness. suitable effect

Pending Publication Date: 2021-03-09
JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main ingredient of echinacoside is large, the API has strong hygroscopicity, and wet granulation is easy to stick, so it is suitable for dry granulation, but dry granulation has a high proportion of the main ingredient, low tablet hardness, and is not easy to form

Method used

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  • Echinacoside preparation and preparation method thereof
  • Echinacoside preparation and preparation method thereof
  • Echinacoside preparation and preparation method thereof

Examples

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preparation example Construction

[0052] The invention provides a preparation method of echinacoside tablet, comprising:

[0053] Grinding and sieving echinacoside to obtain pretreated echinacoside;

[0054] Stirring and mixing the pretreated echinacoside with a filler, a disintegrant, a binder and a lubricant, compressing into tablets, coating and drying the tablets;

[0055] Or preliminarily stir and mix the pretreated echinacoside with fillers, disintegrants, binders and lubricants, granulate and granulate. The granules are further mixed with the remaining lubricant, compressed into tablets, coated and air-dried to obtain the tablets.

[0056] The present invention has clearly described the specific composition and proportion of the above-mentioned components above, and will not repeat them here.

[0057] The preparation method of the echinacoside tablet provided by the present invention firstly pulverizes echinacoside and sieves to obtain pretreated echinacoside.

[0058] Preferably, the raw material dr...

Embodiment 1～8

[0073] Table 1

[0074]

[0075] Embodiment Echinacoside common tablet preparation method:

[0076] Take echinacoside according to the parts by weight in Table 1, add a filler, add an appropriate amount of disintegrant, add a binder, add magnesium stearate lubricant, mix well, and prepare tablets by a tablet machine; or after mixing Made into granules, and then prepared into tablets by a tablet press.

[0077] Preparation method 1: Examples 1-6

[0078] (1) Pulverize the echinacoside raw material drug, control the particle size of the raw material drug, pass the powder through a 60-150 mesh pharmacopoeia sieve (preferably 120 mesh pharmacopoeia sieve), and weigh each raw and auxiliary material according to the prescription amount.

[0079] (2) Add echinacoside, fillers, disintegrants, binders, and lubricants into the V-type mixing mixer in sequence, and stir at 50-100rpm (optimally 80rpm) for 10-20min (optimally 15min) ;

[0080] (3) Tablet compression: Tablets are comp...

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Abstract

The invention provides an echinacoside preparation. Raw materials of the echinacoside preparation comprise the following components in parts by weight of 5-58 parts of echinacoside; 32-84 parts by weight of a filler; 5-12 parts by weight of a disintegrating agent; 0-5 parts by weight of an adhesive; 0.1 to 2 parts by weight of a lubricant, wherein the filler comprises pregelatinized starch. According to the echinacoside preparation, the pregelatinized starch is used as the filler and is matched with the disintegrating agent, adhesive and lubricant, so that the finally obtained echinacoside tablet is smooth in surface, proper in thickness and hardness, qualified in friability and good in dissolution rate.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an echinacoside preparation and a preparation method thereof. Background technique [0002] During the use of drugs, in order to meet the needs of different drug routes, drug effects, and drug users, it is necessary to make drugs into different dosage forms, such as tablets, pills, injections, aerosols, ointments, etc. Through the study of pharmacy, various biological drugs, chemical raw materials, and traditional Chinese medicine extracts have been made into drugs that can be directly used in the human body, which not only ensures the efficacy of drugs, but also improves the absorption and utilization of drugs. Due to the effectiveness, stability, uniformity, and economical properties of pharmaceutical preparations, it not only ensures the convenience of medication for patients, but also ensures the controllability of drug quality and reduces the risk of drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/36A61K31/7032A61P25/16A61P25/28A61P9/10A61P11/00A61P1/16
CPCA61K9/28A61K9/2059A61K31/7032A61P25/16A61P25/28A61P9/10A61P11/00A61P1/16
Inventor 颜凡莉陈明霞姜海燕易斌韩雅慧岳玉荣孙彦辉
Owner JIANCHANGBANG CHINESE HERBAL MEDICINE CO LTD
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