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Preparation method of astaxanthin ester nano-composite particles

A technology of nano-composite and astaxanthin ester, applied in the field of astaxanthin, can solve the problems of poor water solubility and storage stability of astaxanthin ester, improve thermal stability, processing, storage and transportation stability, and a simple preparation method , the effect of good liquidity

Pending Publication Date: 2021-02-26
RIZHAO POLYTECHNIC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problems of poor water solubility and storage stability of astaxanthin esters, the present invention provides a method for preparing astaxanthin ester nanocomposite particles. The astaxanthin esters prepared by this method have thermal stability and processing, storage and transportation stability Significantly improved, good dispersion in water, so it has good processing and application performance; no alcohol solvents and surfactants are used in the preparation process, thereby avoiding the residual problems caused by alcohol solvents and surfactants, and improving safety

Method used

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  • Preparation method of astaxanthin ester nano-composite particles
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  • Preparation method of astaxanthin ester nano-composite particles

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Embodiment 1

[0033] Such as figure 1 Shown, a kind of preparation method of astaxanthin ester nanocomposite particle, preparation method comprises the following steps:

[0034] (1) Preparation of aqueous phase solution: zein was dissolved in a phosphate buffer solution with a pH of 6.5 at a mass volume ratio of 1 g / 100 mL, and hydrated at 5° C. for 4 hours to obtain an aqueous phase solution;

[0035] (2) Preparation of oil phase solution: dissolving astaxanthin ester in straight-chain fatty acid ester at a mass volume ratio of 10 g / 100 mL at 25° C. to prepare an oil solution of astaxanthin ester;

[0036] (3) Primary emulsification: Add the astaxanthin ester oil phase solution prepared in step (2) to the aqueous phase solution prepared in step (1) at a mass ratio of 1:5, and add 0.0025 g of astaxanthin ester to the system at the same time / 100mL of tea polyphenols, and then use high-pressure micro-jet to fully homogeneously emulsify, the emulsification condition is a homogeneous pressure...

Embodiment 2

[0041] A preparation method of astaxanthin ester nanocomposite particles, the preparation method comprising the following steps:

[0042] (1) Preparation of aqueous phase solution: Dissolve the mixture of wheat prolamin and kafirin (the mass ratio of wheat prolamin and kafirin is 1:1) according to the mass volume ratio of 4g / 100mL In a phosphate buffer solution with a pH of 7.5, hydrate at 15°C for 10 hours to obtain an aqueous phase solution;

[0043] (2) Preparation of the oil phase solution: dissolving the astaxanthin ester in fatty acid glycerides in an amount of 45 g / 100 mL at a mass volume ratio of 70° C. to prepare an oil solution of the astaxanthin ester;

[0044] (3) Primary emulsification: Add the astaxanthin ester oil phase solution prepared in step (2) to the aqueous phase solution prepared in step (1) at a mass ratio of 1:15, and simultaneously add 0.75 g of / 100mL of tea polyphenols, and then fully homogeneously emulsified by high-pressure micro-jet, the emulsific...

Embodiment 3

[0049] A preparation method of astaxanthin ester nanocomposite particles, the preparation method comprising the following steps:

[0050] (1) Preparation of aqueous phase solution: hordein was dissolved in deionized water with a pH of 7.0 at a mass volume ratio of 2.5 g / 100 mL, hydrated at 10°C for 8 hours to obtain an aqueous phase solution, and added to water A stabilizer with a mass volume ratio of 2.5g / 100mL is added to the phase solution, and the stabilizer includes soybean protein, lysozyme and chitosan with a mass ratio of 1:1:0.5;

[0051] (2) Preparation of oil phase solution: dissolving astaxanthin ester in fatty acid glyceride in an amount of 30 g / 100 mL by mass volume ratio at 40° C. to prepare an oil solution of astaxanthin ester;

[0052] (3) Primary emulsification: Add the astaxanthin ester oil phase solution prepared in step (2) to the aqueous phase solution prepared in step (1) at a mass ratio of 1:10, and add 0.05 g of astaxanthin ester to the system at the s...

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Abstract

The invention relates to the technical field of astaxanthin, in particular to a preparation method of astaxanthin ester nano-composite particles. The preparation method comprises the following steps:dissolving protein in deionized water or a buffer solution, and hydrating to obtain an aqueous phase solution; dissolving astaxanthin ester in the oil phase to prepare an astaxanthin ester oil solution; adding the astaxanthin ester oil solution into the aqueous phase solution, adding tea polyphenol into the system at the same time, and then fully homogenizing and emulsifying the system by adoptinghigh-pressure microjet; adjusting the pH value of the emulsified system to 11-13 by using an alkaline substance, and carrying out secondary homogeneous emulsification; adjusting the pH value of the system subjected to secondary emulsification to 6.5-7.2 by using an acidic substance while stirring; and drying. The astaxanthin ester prepared by the method has obviously improved thermal stability and processing, storage and transportation stability, has good dispersibility in water, and has good processing and application performance; and in the preparation process, an alcohol solvent and a surfactant are not used, so that the problem of residues caused by the alcohol solvent and the surfactant is avoided, and the safety is improved.

Description

technical field [0001] The invention relates to the technical field of astaxanthin, in particular to a method for preparing astaxanthin ester nanocomposite particles. Background technique [0002] Astaxanthin is the strongest natural antioxidant found in nature so far, known as a super antioxidant. More and more research results show that astaxanthin has a variety of physiological activities, such as anti-aging, anti-tumor, prevention of cardiovascular and cerebrovascular diseases, liver protection, anti-diabetes, anti-inflammation, improvement of motor function, and astaxanthin It is the only carotenoid found so far that can penetrate the blood-brain and blood-retinal barriers, and can have a positive impact on the central nervous system and brain function. Therefore, adding astaxanthin as a dietary functional factor to food, cosmetics and other products has practical significance for improving health. [0003] In nature, more than 90% of astaxanthin exists in the form of...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K9/14A61K9/19A23L33/10A61K8/02A61K8/37A61K8/64A61K47/14A61K47/42A61P1/16A61P3/10A61P9/00A61P25/00A61P29/00A61P35/00A61P39/06B82Y5/00B82Y30/00B82Y40/00
CPCA61K31/122A61K8/37A61K8/0225A61K8/64A61K9/146A61K9/145A61K47/42A61K47/14A61K9/19B82Y5/00B82Y30/00B82Y40/00A61P39/06A61P35/00A61P9/00A61P1/16A61P3/10A61P29/00A61P25/00A23L33/10A61K2800/84A23V2002/00A23V2200/302A23V2200/308A23V2200/30A23V2200/326A23V2200/328
Inventor 周庆新谷彩霞徐泽生韩鑫杰郭楚璇王辉
Owner RIZHAO POLYTECHNIC
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