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Block copolymer and its preparation method and application

A technology of block copolymer and polymerization reaction, applied in the field of block copolymer and its preparation, can solve the problems of difficult purification, low yield of block copolymer, inability to realize the preparation of dopamine and zwitterionic compound block polymer, and the like, To achieve the effect of easy purification and efficient synthesis

Active Publication Date: 2021-09-21
TSINGHUA UNIV +1
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of random copolymers is far less excellent than that of block polymers
However, there are often a large number of random copolymers in the products obtained by the traditional block polymer preparation method, resulting in low yield of block copolymers, difficult purification, and the preparation of dopamine and zwitterionic compound block polymers cannot be realized.

Method used

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  • Block copolymer and its preparation method and application
  • Block copolymer and its preparation method and application
  • Block copolymer and its preparation method and application

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preparation example Construction

[0037] see figure 1 , the embodiment of the present invention provides a kind of preparation method of block copolymer, comprises the following steps:

[0038] S10, dissolving the dopamine derivative a having an active alkenyl group, the hydrophilic chain transfer reagent and the hydrophilic initiator in a solvent, performing the first polymerization reaction under an inert atmosphere, and quenching under an oxygen atmosphere to obtain a first reaction solution , the solvent is a solvent that is miscible in any proportion of water;

[0039]S20, adding a zwitterionic compound having an active alkenyl group, a hydrophilic initiator and water into the first reaction solution, performing a second polymerization reaction under an inert atmosphere, and quenching under an oxygen atmosphere to obtain a second reaction solution;

[0040] S30, adding the dopamine derivative b having an active alkenyl group and the hydrophilic initiator into the second reaction solution, performing the ...

Embodiment 1

[0113] The preparation of embodiment 1 block polymer PDMA-b-PMPC-b-PDMA

[0114] The synthetic route is as follows:

[0115]

[0116] (1) Weigh 120mg DMA (the dopamine methacrylamide prepared above), 13mg chain transfer reagent 2-cyano-2-propylbenzodisulfide, 2.8mg initiator 4,4'-azobis( 4-cyanovaleric acid) was added to a 50mL flask, 10mL DMF was added to dissolve the solid, and the bottle mouth was blocked with a rubber stopper in time, nitrogen was passed through for 30min to remove oxygen, the reaction temperature was 70°C, and stirred for 12h. After the reaction was completed, the reaction was quenched by passing into air .

[0117] (2) Weigh 1.18g of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2.8mg of 4'-azobis(4-cyanovaleric acid) into the above 50mL flask, add 15mL of ultrapure water Dissolve the solid and stop the bottle mouth with a rubber stopper in time, pass nitrogen gas for 30 minutes to remove oxygen, the reaction temperature is 65°C, stir for 12 ho...

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Abstract

The invention relates to a preparation method of a block copolymer, comprising the following steps: dissolving a dopamine derivative a having an active alkenyl group, a hydrophilic chain transfer reagent and a hydrophilic initiator in an organic solvent, and carrying out the process under an inert atmosphere The first polymerization reaction is quenched under an oxygen atmosphere to obtain the first reaction liquid, and the organic solvent is an organic substance that is miscible in any proportion of water; a zwitterionic compound having an active alkenyl group, a hydrophilic initiator and water are added to the In the first reaction liquid, the second polymerization reaction is carried out under an inert atmosphere, and the second reaction liquid is obtained by quenching under an oxygen atmosphere; the dopamine derivative b having an active alkenyl group and a hydrophilic initiator are added to the second reaction liquid In the process, the third polymerization reaction is carried out under an inert atmosphere, quenched under an oxygen atmosphere to obtain a third reaction solution, and the solvent is removed to obtain the block copolymer. The invention also relates to a block copolymer and medical materials.

Description

technical field [0001] The invention relates to the technical field of functional polymer materials, in particular to a block copolymer and its preparation method and application. Background technique [0002] Block copolymers are linear copolymers formed by the alternating polymerization of chain segments with different chemical structures. It can combine the excellent properties of various polymers to obtain functional polymer materials with superior performance. This kind of polymer has controllable molecular weight, narrow molecular weight distribution, and designable molecular structure and composition. It is one of the most meaningful and challenging research tasks in the field of polymer research. Block copolymers have very important academic value and potential application prospects in the fields of biomedicine, tissue engineering, and intelligent sensing. It is of great significance to expand the development and application of block copolymers in the field of self...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F2/38
CPCC08F2/38C08F293/005C08F2438/03
Inventor 张洪玉王海蟒
Owner TSINGHUA UNIV
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