Traditional Chinese medicine composition for treating sepsis cognitive disorder and preparation method of composition

A technology for cognitive impairment and cognitive dysfunction, applied in the field of traditional Chinese medicine compositions and preparations for the treatment of cognitive impairment in sepsis, can solve problems such as cognitive dysfunction, social and family burden, and improve inflammation and cognition. The effect of dysfunction

Pending Publication Date: 2021-02-09
BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even among surviving sepsis patients, a large proportion have long-term cognitive impairment, which imposes a serious burden on society and families

Method used

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  • Traditional Chinese medicine composition for treating sepsis cognitive disorder and preparation method of composition
  • Traditional Chinese medicine composition for treating sepsis cognitive disorder and preparation method of composition
  • Traditional Chinese medicine composition for treating sepsis cognitive disorder and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] According to the weight ratio, weigh 45 parts of ginseng, prepare 90 parts of aconite, 45 parts of raw rhubarb, 30 parts of Gastrodia elata, 20 parts of ginkgo biloba, 20 parts of cassia twig, and 12 parts of scutellaria baicalensis. Place the above medicinal materials in a decoction pot, and completely submerge the medicinal materials with pure water. The volume of pure water is twice the volume of the medicinal materials. Soak at room temperature for 30-60 minutes; , to prevent the active ingredients of the drug from volatilizing, and filter out the liquid medicine; and add pure water to the above-mentioned medicinal residues, subject to completely submerging the medicinal residues, boil on high heat, then boil on low heat for 30 minutes, filter out the medicinal liquid, and use the same method as the first Mix the liquid medicine evenly and drink it several times.

Embodiment 2

[0029] Decoction according to the method of Example 1, wherein each component is according to the following weight ratio: 30 parts of ginseng, 120 parts of prepared aconite, 60 parts of raw rhubarb, 40 parts of Gastrodia elata, 10 parts of ginkgo biloba, 10 parts of cassia twig, 5 parts of Scutellaria baicalensis .

Embodiment 3

[0031] Decoction according to the method of Example 1, wherein each component is according to the following weight ratio: 50 parts of ginseng, 100 parts of prepared aconite, 40 parts of raw rhubarb, 20 parts of Gastrodia elata, 10 parts of ginkgo biloba, 20 parts of cassia twig, 10 parts of scutellaria baicalensis .

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Abstract

The invention discloses a traditional Chinese medicine composition for treating sepsis cognitive disorder and a preparation method of the composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 30-60 parts of ginseng, 60-120 parts of radix aconiti lateralis preparata, 30-60 parts of raw rhubarb, 20-40 parts of rhizoma gastrodiae, 10-30 partsof folium ginkgo, 10-30 parts of cassia twig and 5-20 parts of radix scutellariae. The fEPSP (Field Post-Synaptic Potential) of the hippocampus CA1 region of a sepsis mouse is recorded with a nerve electrophysiology technology, and the slope, namely, the LTP (Long-Term-Depression) amplitude is analyzed. Experiments find that the LTP of the hippocampus CA1 region of the sepsis mouse is remarkablyreduced, and the traditional Chinese medicine composition can remarkably improve the LTP of the hippocampus region and has a certain effect on improvement of sepsis cognitive disorder when applied totreatment.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method for treating sepsis cognitive impairment. Background technique [0002] About 100 people per 100,000 people worldwide are infected with sepsis every year, and sepsis is the leading cause of death among patients in the Intensive Care Unit (ICU) of major hospitals. According to epidemiological statistics, the mortality rate of septic shock is as high as 46.5%, the mortality rate of ICU sepsis patients is about 40% within 1 year after discharge, and the mortality rate after 5 years is about 80%. Accompanied by severe sequelae is a prominent problem faced by the global medical community. Patients with sepsis often cause focal or diffuse dysfunction of the brain, and a series of clinical syndromes such as inattention, delirium, coma, and cognitive impairment, which are called sepsis-associated encephalopathy ( Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/28A61P31/04
CPCA61K36/16A61K36/258A61K36/539A61K36/54A61K36/708A61K36/714A61K36/8988A61K2236/331A61K2236/51A61P25/28A61P31/04A61K2300/00
Inventor 刘清泉王雪蕊郭玉红
Owner BEIJING CHINESE MEDICINE HOSPITAL AFFILIATED CAPITAL MEDICAL UNIV
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