Enzyme-free glucose sensor, production method and application thereof

Abstract

The invention relates to the technical field of glucose detection, and particularly relates to an enzyme-free glucose sensor, a production method and an application thereof. Magnolia grandiflora leaves are used as a carbon-based catalyst, nickel atoms are well dispersed when the magnolia grandiflora leaves are used as a substrate material, and the catalytic activity of the material is improved. And the prepared Ni@ NSiC nano molecular layer is modified on a pretreated white glassy carbon electrode to obtain a high-activity modified working electrode Ni@ NSiC / GCE, and glucose is detected by adopting a cyclic voltammetry and a chronoamperometry. The method solves a problem that dopamine, ascorbic acid, uric acid and other easily oxidized interfering substances exist when the glucose is detected through a traditional electrooxidation method. Test results show that the material has excellent electrochemical sensing performance on the glucose, has relatively high sensitivity, a good stability and anti-interference capability, and has a wide application prospect in the fields of electro-catalysis and biosensing.

Description

technical field [0001] The invention relates to the technical field of glucose detection, in particular to an enzyme-free glucose sensor and its preparation method and application. Background technique [0002] Nickel-based materials are recognized as ideal electrocatalytic oxidants for glucose, and many studies on these materials have been reported. Ni(OH) 2 The electrochemical stability of NiO and NiO make them favored by researchers, but they still face the problem of low electrical conductivity. Nickel metal nanoparticles (Ni-NPs) although with Ni(OH) 2 Compared with NiO, it has excellent electrical conductivity, but due to its small size and strong magnetic properties, it is prone to agglomeration, easy to deactivate during the catalytic process, and poor stability, which limits its further development in the field of nanomaterials. Electrochemical catalysis . In the past decades, it has been expected to develop nickel nanoparticles with high stability and good elec...

AI Technical Summary

Problems solved by technology

The detection of glucose on the traditional electrode is slow due to the slow response of the electrode material, which depends on the oxidase molecule and is easily affected by temperature and pH, resulting in a large error in the detection result.

Another difficulty in electrochemical detection is the need to eliminate the influence of common interfering substances that are prone to electrooxidation in biological samples, such as dopamine, ascorbic acid, and uric acid.

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