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Isolator and hydrogen peroxide gas sterilization method

A hydrogen peroxide and isolator technology, applied in chemistry, disinfection, etc., can solve the problems of weak reliability in the sterilization process, and achieve the effect of enhanced reliability and good reliability

Active Publication Date: 2021-01-05
杭州东生生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the rate of hydrogen peroxide gas passing into the isolator is constant, and the environmental conditions of the isolator for each sterilization may not be exactly the same, the reliability of the sterilization process carried out by hydrogen peroxide gas on the inside of the isolator is relatively low. weak

Method used

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  • Isolator and hydrogen peroxide gas sterilization method
  • Isolator and hydrogen peroxide gas sterilization method
  • Isolator and hydrogen peroxide gas sterilization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] refer to figure 1 , is an isolator disclosed in this application, specifically including:

[0067] The operation panel 101 is used to receive the sterilization instruction input by the experimenter;

[0068] Hydrogen peroxide generator 102, for generating hydrogen peroxide gas, and passing hydrogen peroxide gas into the isolator;

[0069] The processing module 104 is used to control the hydrogen peroxide generator 102 to control the hydrogen peroxide gas concentration in the isolator according to the sterilization instruction, so that the hydrogen peroxide gas completes the sterilization process inside the isolator;

[0070] The sensing module 103 is used for real-time monitoring and feeding back the concentration of hydrogen peroxide gas in the isolator to the processing module 104;

[0071] The residue removal module 105 is used to remove the hydrogen peroxide gas in the isolator after the hydrogen peroxide gas sterilizes the inside of the isolator;

[0072] Among ...

Embodiment 2

[0114] refer to image 3 , is a hydrogen peroxide gas sterilization method disclosed in the present application. This embodiment is applied to the isolator described in Embodiment 1. The method described in this embodiment specifically includes:

[0115] 201. Obtain a self-inspection instruction input by an experimenter.

[0116] 202. According to the self-inspection instruction, the airtightness inside the isolator is inspected.

[0117] Specifically, A1. After closing the hatch of the isolator, obtain the self-inspection parameters according to the self-inspection instruction. The self-inspection parameters include at least positive pressure threshold, voltage stabilization time limit, self-inspection time limit and qualified loss;

[0118] The positive pressure threshold above is used to illustrate the positive pressure value that the isolator needs to achieve during self-test;

[0119] The above voltage stabilization time limit is used to explain the time limit for the i...

Embodiment 3

[0165] refer to Figure 4 , is a hydrogen peroxide gas sterilization method disclosed in this application. This embodiment is based on the scheme of Embodiment 2, and has been optimized and improved. In particular, the saturation threshold, the second Sterilization time limit, upper limit of saturation and lower limit of saturation; at the same time, during the execution of step 208, step 300 is executed synchronously, and the improved part will be further elaborated below:

[0166] The saturation threshold above is used to illustrate the optimum saturation for hydrogen peroxide gas sterilization;

[0167] The above-mentioned second sterilization time limit is used to illustrate that hydrogen peroxide gas needs to maintain the minimum time limit of the saturation threshold to achieve the expected sterilization effect. The second sterilization time limit is shorter than the first sterilization time limit mentioned in Example 1. Bacteria time limit;

[0168] The above upper li...

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Abstract

The application relates to the technical field of sterile isolators and particularly relates to an isolator and a hydrogen peroxide gas sterilization method. The method specifically comprises the steps: acquiring a sterilization instruction input by experimentation personnel; acquiring sterilization parameters according to the sterilization instruction, wherein the sterilization parameters at least comprise a concentration threshold and a concentration fluctuation range; continuously introducing hydrogen peroxide gas into the isolator, so as to enable a concentration of hydrogen peroxide in air inside the isolator to reach the concentration threshold; after the concentration of the hydrogen peroxide gas in the isolator reaches the concentration threshold, maintaining the concentration of the hydrogen peroxide gas in the isolator in the concentration fluctuation range, so as to enable the hydrogen peroxide gas to carry out sterilization on the interior of the isolator; and after the interior of the isolator is sterilized by the hydrogen peroxide gas, the hydrogen peroxide gas is removed from the isolator. According to the method disclosed by the application, the aim of improving thereliability of a hydrogen peroxide gas sterilization process is achieved through controlling the concentration of the hydrogen peroxide gas.

Description

technical field [0001] The present application relates to the technical field of aseptic isolators, in particular to an isolator and a hydrogen peroxide gas sterilization method. Background technique [0002] In the process of aseptic production and testing, it is necessary to keep the production and testing environment in a sterile state. Generally, an aseptic isolator is used. The aseptic isolator is sterilized online by hydrogen peroxide gas. After biological decontamination, it is sterile Provide a continuous aseptic environment for bacterial production and testing operations. [0003] In the related art, when the aseptic isolator is sterilized with hydrogen peroxide gas, hydrogen peroxide gas for sterilization will be introduced at a constant first rate, and the hydrogen peroxide gas will be continuously injected at the first rate After a period of time, the hydrogen peroxide gas will be passed into the isolator at a constant second rate, and the second rate is less th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/20
CPCA61L2/208
Inventor 王诗华张旭任江良顾天宇
Owner 杭州东生生物技术有限公司
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