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Soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer as well as preparation method and application of soluble drug-loaded microneedle patch

A micro-needle sticking and dissolving technology, which is applied in the field of biomedical materials, can solve the problems of complex, difficult to change, and fixed size of the micro-needle negative mold, and achieves the improvement of local effective drug concentration, the preparation method is simple and clear, and the size is controllable. Effect

Pending Publication Date: 2020-12-29
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the purposes of the present invention is to invent a fast, low-cost, large-scale and personalized production method based on 3D printing technology in order to improve the defects of the existing microneedle female mold production method, which are complicated, high in cost, fixed in size and difficult to change. Microneedle negative mold method

Method used

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  • Soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer as well as preparation method and application of soluble drug-loaded microneedle patch
  • Soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer as well as preparation method and application of soluble drug-loaded microneedle patch
  • Soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer as well as preparation method and application of soluble drug-loaded microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: 3D printing microneedle negative mold

[0026] S1, through 3DMax design the microneedle negative mold model that meets the requirements of the present invention. The microneedle negative mold used in the present invention is a conical microneedle with a diameter of 0.75 mm and a height of 3 mm, and is saved in an STL format file.

[0027] S2, import the STL file into the light-curing 3D printer, and use the 3D printed light-curing resin to print, and the thickness of the slice is 0.05mm.

[0028] S3, after the printing is completed, soak the model with isopropanol solution for 10 minutes to wash away excess resin and obtain a negative microneedle model.

Embodiment 2

[0029] Example 2 Preparation of soluble drug-loaded hyaluronic acid microneedle patch

[0030] S1, using the 3D printed microneedle template in Example 1;

[0031] S2, preparation of hyaluronic acid substrate preparation solution (10%, w / v): Weigh 1 g of sodium hyaluronate (molecular weight 40,000-100,000) and dissolve it in 9 mL of deionized water, and stir for 24 hours under magnetic stirring to ensure sufficient swelling;

[0032] S31, the weight ratio of bovine basic fibroblast growth factor, cetylpyridinium chloride and hyaluronic acid substrate preparation solution in the needle body preparation solution is (0.08~0.1)×10 -5 : 0.05~0.1:1 onto the microneedle template in step S1, and centrifuged in a 10mL centrifuge tube at 3000rpm for 1h, so that the microneedle template needle tip preparation solution fills the pinhole;

[0033]S32, placing the microneedle template containing the needle tip preparation solution in step S31 in a vacuum drying oven, adjusting the air pres...

Embodiment 3

[0039] Example 3 Preparation of soluble drug-loaded sodium alginate microneedle patch

[0040] S1, using the 3D printed microneedle template in Example 1;

[0041] S2, preparation of sodium alginate substrate preparation solution (5%, w / v): Weigh 0.5 g of sodium alginate and dissolve it in 9.5 mL of deionized water, stir magnetically at 50 °C for 24 hours to ensure sufficient swelling;

[0042] S31, the weight ratio of recombinant human epidermal growth factor, compound chlorhexidine, and sodium alginate substrate preparation solution in the preparation solution of the needle body is (0.05-0.15)×10 -5 : 0.05~0.1:1 onto the microneedle template in step S1, and centrifuged in a 10mL centrifuge tube at 3000rpm for 1h, so that the microneedle template needle tip preparation solution fills the pinhole;

[0043] S32, placing the microneedle template containing the needle tip preparation solution in step S31 in a vacuum drying oven, adjusting the air pressure to 0.1Pa, drying at 37°...

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Abstract

The invention discloses a microneedle female die prepared based on a 3D printing technology, a soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer prepared by taking the microneedle female die as a template, and a preparation method and application of the soluble drug-loaded microneedle patch. According to the invention, the microneedle female die is prepared by adopting the 3D printing technology, so that the preparation process of the microneedle template can be simplified, and the advantages of controllable size, large scale, high precision, economy, high efficiencyand the like are achieved. Meanwhile, according to the female die prepared on the basis of 3D printing, a polymer with high biocompatibility is used as a microneedle matrix, growth factors and antibacterial drugs are compounded, and the layered microneedle patch is constructed by adopting a centrifugal perfusion method. The microneedle patch has the advantages of being high in biocompatibility, minimally invasive, painless and the like, can pierce the ulcer surface and be dissolved immediately, the loaded therapeutic drug is effectively released to the deep layer of the ulcer surface, the dualpurposes of inhibiting mycoderm formation and promoting ulcer healing are achieved, and the ulcer healing time is effectively shortened.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a soluble drug-loaded microneedle patch for treating recurrent aphthous ulcer and its preparation method and application. Background technique [0002] Recurrent aphthous ulcer (RAU) is the most common oral mucosal ulcer disease, with a prevalence rate as high as 66%, and a high recurrence rate. Due to the rich distribution of nerves in the oral mucosa, RAU is often accompanied by pain, which seriously affects the patient's eating, language and other functions. The etiology and pathogenesis of RAU have not been fully clarified. At present, there is no effective cure at home and abroad. The clinical treatment is mainly local symptomatic treatment. Topical medications include gargles, lozenges, sprays, gels, and films. However, due to the special environment of the oral cavity, topical medication will be affected by the continuous secretion of saliva and the movement...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K31/4425A61K9/70A61K47/36A61K47/38A61K47/32A61K47/42A61P1/02A61M37/00A61K31/155
CPCA61K38/1825A61K31/4425A61K38/1808A61K31/155A61K9/7023A61K9/0021A61K47/36A61K47/38A61K47/32A61K47/42A61P1/02A61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061A61K2300/00B33Y10/00B33Y70/00B33Y50/00
Inventor 范增杰伊峥嵘
Owner LANZHOU UNIVERSITY
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