Application of Pien Tze Huang and preparation thereof in preparation of medicine for preventing and treating enterovirus EV71 infection

Abstract

The invention belongs to the field of traditional Chinese medicine, and particularly relates to application of Pien Tze Huang and a preparation thereof in preparation of a medicine for resisting enterovirus EV71 infection. The invention discloses application of the Pien Tze Huang in preparation of the medicine for resisting enterovirus EV71 infection, and antiviral activity research on the application shows that the Pien Tze Huang significantly inhibits cytopathy, inhibits virus replication and reduces the virus particle loading capacity in the enterovirus EV71 infection process and has higheranti-EV71 virus activity, and a scientific basis is provided for the new application of the Pien Tze Huang.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of Pien Tze Huang and its preparations in the preparation of medicines for preventing and treating enterovirus EV71 infection. Background technique [0002] Enterovirus 71 (Enterovirus 71, EV71) is a neurotropic virus that belongs to the family Picornaviridae Enterovirus, and is one of the main pathogens that cause hand, foot and mouth disease, angina or rash in children, especially hand, foot and mouth disease. , EV71-positive cases accounted for about 44% of HFMD cases with laboratory etiological diagnosis results, EV71-positive cases accounted for 74% of severe cases, and 93% of death cases. EV71 infection seriously affects people's daily life and life health, and has become an important global public health problem, which has attracted extensive attention and research from various health institutions and research institutions around the...

AI Technical Summary

Problems solved by technology

Although drugs have been used to treat EV71 HFMD clinically, they have not been standardized and widely used, and there are still some deficiencies: 1) most clinical trials of drugs are tested in a small range, lacking evidence-based basis; 2) for the treatment of There are far more drugs in EV71 infection models (cells and animals) than in clinical trials; 3) Differences between animal infection models and clinical human infections increase the uncertainty of drugs in the clinical research phase; 4) EV71 The high mortality rate of children with severe hand, foot and mouth disease is mainly due to severe complications such as neurogenic pulmonary edema, aseptic meningitis, and encephalitis. However, the mechanism has not been clarified, which limits the development of anti-EV71 drugs

[0005] At present, there is no therapeutic drug for EV71 infection. Due to the time-consuming, high cost and high risk of new drug development, screening of anti-EV71 infection drugs from marketed drugs provides ideas for symptomatic treatment and new drug development of EV71 infection diseases

Pien Tze Huang is a heat-clearing and detoxifying Chinese patent medicine that has been used for nearly 500 years. Preliminary pharmacological effects and clinical studies have shown that Pien Tze Huang has significant anti-inflammatory, antipyretic, immune regulation, and tumor treatment effects. There is no report that Pien Tze Huang is effective in treating EV71 infection. The application of drugs such as hand, foot and mouth disease, angina or rash

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