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Application of fangchinoline in preparation of medicine for preventing and treating ulcerative colitis

A technology for ulcerative colitis and fangchinoline, applied in the field of medicine

Inactive Publication Date: 2020-12-29
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no relevant report that fangchinoline can be used as the only active ingredient in the preparation of drugs for the prevention or treatment of ulcerative colitis

Method used

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  • Application of fangchinoline in preparation of medicine for preventing and treating ulcerative colitis
  • Application of fangchinoline in preparation of medicine for preventing and treating ulcerative colitis
  • Application of fangchinoline in preparation of medicine for preventing and treating ulcerative colitis

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Experimental program
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Effect test

Embodiment 1

[0027] 1. Experimental materials

[0028] 1.1 Medicinal materials

[0029] Fangchinoline base (CAS: 436-77-1, MW 608.71, HPLC purity ≥ 98%, Chengdu Alpha Biotechnology Co., Ltd.); Dextran sodium sulfate (DSS, CAS: 9011-18-1, MW 36- 50kDa, produced by MP Biomedicals, USA); sulfasalazine (SASP, CAS: 599-79-1, molecular weight 398.39, HPLC purity ≥ 98%, produced by Sigma-Aldrich, USA).

[0030] 1.2 Experimental animals

[0031] C57BL / 6J female mice (8 weeks) weighing 20±2 g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2018-0032. Placed in a conventional feeding environment, free access to food and water.

[0032] 2. Experimental method

[0033] 2.1 Establishment of ulcerative colitis model

[0034] C57BL / 6J female mice (20±2g) with uniform body weight were selected, and the internationally accepted ulcerative colitis modeling method was adopted (Gastroenterology 2002,123:256...

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Abstract

The invention relates to the field of medicine, in particular to a new medical use of a bisbenzylisoquinoline alkaloid compound. The invention provides an application of fangchinoline in the preparation of a medicine for preventing and treating ulcerative colitis. Preferably, fangchinoline is used as a unique active ingredient for preparing the medicine for preventing and treating ulcerative colitis. Fangchinoline can be used for preparing the medicine for preventing and treating ulcerative colitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new application of a bisbenzylisoquinoline alkaloid compound. Background technique [0002] Ulcerative colitis (UC) is an intestinal inflammatory disease of unknown etiology and easily relapses, which together with Crohn's disease (CD) constitutes inflammatory bowel disease (IBD). UC can occur in all age groups. It is difficult to cure, and its incidence is increasing significantly in our country. It is one of the modern intractable diseases. The lesion mainly involves the chronic non-specific inflammation of the colorectal mucosa, mainly abdominal pain, diarrhea, mucus and bloody stools, and tenesmus. At present, Western medicine is the main treatment for UC, including steroids and non-steroids, such as glucocorticoids, aminosalicylic acids, antibiotics and immunosuppressants. However, long-term use of these drugs has relatively large side effects, and it is easy to rebound after dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P1/04A61P1/00
CPCA61K31/4748A61P1/00A61P1/04
Inventor 窦薇于之伦岳备任怡静张婧任君宇王峥涛
Owner SHANGHAI UNIV OF T C M
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