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Application of mozavaptan in preparation of anti-digestive tract tumor drugs

A technology of digestive tract tumors and anti-tumor drugs, applied in the field of biomedicine, can solve the problems of less than 20% survival rate, poor prognosis of patients with esophageal cancer and poor 5-year survival rate

Active Publication Date: 2020-12-25
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although China has attached great importance to the diagnosis and treatment of esophageal cancer for many years, 90% of the diagnosed patients with esophageal cancer are in the advanced stage, and the 5-year survival rate is less than 20%
Despite the continuous development of comprehensive treatment methods such as surgery, radiotherapy and chemotherapy, the prognosis and 5-year survival rate of patients with esophageal cancer are still poor

Method used

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  • Application of mozavaptan in preparation of anti-digestive tract tumor drugs
  • Application of mozavaptan in preparation of anti-digestive tract tumor drugs
  • Application of mozavaptan in preparation of anti-digestive tract tumor drugs

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Embodiment Construction

[0022] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0023] application test

[0024] Materials and Methods

[0025] 1. Material

[0026] 1.1 Reagents

[0027] Mozavatan was purchased from Shanghai Taosu Biochemical Technology Co., Ltd., with a purity of 99.1%; 4% paraformaldehyde was purchased from Zhengzhou Paini Chemical Reagent Factory; DMSO was purchased from American sigma-aldrich company; agar powder was purchased from Beijing Suolaibao Technology Co., Ltd.; Basal Medium Eagle was purchased from sigma-aldrich in the United States; L-glutamine was purchased from Beijing Suo Lai Bao Technology Co., Ltd.; NaHCO3 was purchased from Tianjin Kaitong Chemical Reagent Co., Ltd.; fetal bovine serum was purchased from Biological Industries, Israel ; penicillin and streptomycin were purchased from North China Pharmaceutical C...

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Abstract

The invention discloses an application of mozavaptan in preparation of anti-digestive tract tumor drugs, the chemical name of the mozavaptan is 5-(dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazephe, and experiments prove that the mozavaptan can inhibit esophageal squamous cell carcinoma cells KYSE150 and KYSE450, proliferation of gastric cancer cells HGC27 and AGS, clone formation of esophageal squamous carcinoma cells and induce the cell apoptosis. Therefore, it is shown that mozavaptan has a remarkable inhibition effect on esophageal squamous cell carcinoma cells. Therefore, the mozavaptan can be used as an existing clinical medicine to play a role in preventing and treating tumors. The invention provides a new application of mozavaptan in tumor treatment and prevention.

Description

technical field [0001] The application belongs to the field of biomedicine, and specifically relates to the application of mozavatan in the preparation of antitumor drugs. Background technique [0002] Esophageal cancer (Esophagus cancer) is a kind of digestive tract tumor derived from esophageal epithelium, and the typical symptoms are progressive dysphagia. In 2018, 572,000 people were newly diagnosed with esophageal cancer, and 509,000 people died of esophageal cancer at the same time, ranking seventh and sixth in terms of morbidity and mortality among all cancers. Esophageal cancer also has obvious regional differences. It is most common in East Asia, and there are relatively few developed countries in Europe and the United States. China is a country with a high incidence of esophageal cancer. The incidence of esophageal cancer in China accounts for about 46.6% of esophageal cancer patients in the world. , while the 5-year survival rate of patients with esophageal cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P35/00
CPCA61K31/55A61P35/00
Inventor 刘康栋董子钢刘鑫宁郭智萍赵继敏赵四敏江亚南董子明
Owner ZHENGZHOU UNIV
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