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Methods for treating hpv-associated diseases

Technology of a disease, human papillomavirus, applied in the field of immune cells

Pending Publication Date: 2020-12-18
SQZ BIOTECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most HPV infections are asymptomatic and clear spontaneously, persistent infection in the case of one oncogenic HPV type may develop into precancer or cancer

Method used

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  • Methods for treating hpv-associated diseases
  • Methods for treating hpv-associated diseases
  • Methods for treating hpv-associated diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0281] Embodiment 1. A method for treating a human papillomavirus (HPV)-related disease in an individual, the method comprising administering to the individual an effective amount of a composition comprising modified immune cells, wherein the modified The immune cells contain HPV antigens and an adjuvant, wherein the adjuvant is presented intracellularly.

Embodiment approach 2

[0282] Embodiment 2. A method for preventing an HPV-related disease in an individual, the method comprising administering to the individual an effective amount of a composition comprising a modified immune cell, wherein the modified immune cell comprises an HPV antigen and an adjuvant, wherein the adjuvant is presented intracellularly.

Embodiment approach 3

[0283] Embodiment 3. A method for modulating an immune response in an individual with an HPV-related disease, the method comprising administering to the individual an effective amount of a composition comprising modified immune cells, wherein the modified Immune cells contain HPV antigens and an adjuvant, wherein the adjuvant is presented intracellularly.

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Abstract

The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and / or for modulating an immune response in an individual with an HPV-associated disease.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims US Provisional Application No. 62 / 641,988, filed March 12, 2018, US Provisional Application No. 62 / 794,517, filed January 18, 2019, US Provisional Application No. 62 / 812,225, filed February 28, 2019 priority. This application also claims the benefit of European Patent Application No. EP 19161964.2, filed on March 11, 2019; which is hereby incorporated by reference in its entirety. [0003] Submission of ASCII Text File Sequence Listing [0004] The contents of the following submitted ASCII text file are hereby incorporated by reference in their entirety: Computer-readable form (CRF) of Sequence Listing (File Name: 750322001640SEQLIST.TXT, Record Date: March 11, 2019, Size: 14KB) . technical field [0005] The present disclosure relates generally to immune cells comprising antigens and adjuvants; methods of making such modified immune cells; and use of such modified immune cells to treat, prevent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12C07K14/025A61P31/20
CPCC07K14/025A61K39/12A61K2039/55561A61P31/20A61K39/4611A61K39/4622A61K39/464838A61K2239/39A61K39/4612A61K2239/55A61K39/4615A61K2239/31A61K39/464499A61K45/06C07K14/005A61K2039/545A61K2039/505C12N2710/20034A61P35/00A61K33/243A61K2039/5154A61K2039/55516A61K2039/585
Inventor S·洛克希德L·塔拉里科A·韦森特·苏亚雷斯M·布蒂H·伯恩斯坦K·布拉戈维奇A·R·沙雷K·赫拉维蒂M·迈因特
Owner SQZ BIOTECH CO
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