Endoscopic OCT-Raman dual-mode imaging device and imaging method

Abstract

The invention discloses an endoscopic OCT-Raman dual-mode imaging device and an imaging method. The endoscopic OCT-Raman dual-mode imaging device comprises a Raman imaging system, an OCT imaging system, an endoscope system, an image reconstruction system and a display system, wherein the endoscope system is connected with the Raman imaging system and the OCT imaging system respectively, the Ramanimaging system and the OCT imaging system are both connected with the image reconstruction system, and the image reconstruction system is connected with the display system. According to the OCT-Ramandual-mode imaging device disclosed by the invention, a three-dimensional image with high optical resolution can be obtained, the spectral line form existence mode of a Raman spectrum is changed, the Raman spectrum is associated with OCT three-dimensional imaging, reconstruction of an OCT cavity tiled three-dimensional image and the corresponding Raman three-dimensional image is realized, lesion position correspondence is more obvious, the imaging visualization degree is improved, and accurate and rapid acquisition of OCT imaging data and Raman signals is realized.

Description

technical field [0001] The invention belongs to the technical field of endoscopes, in particular to an endoscope OCT-Raman dual-mode imaging device and an imaging method. Background technique [0002] As a non-invasive or minimally invasive imaging method, endoscopy can penetrate deep into the body cavity of the living body and has been widely used in the imaging diagnosis of multiple cavities such as blood vessels, digestive tract, urinary system and respiratory tract. OCT is a high-resolution imaging and observation method of mesoscopic (micron-scale) living tissue using the coherence principle of scattered light from biological tissue. OCT endoscope is an important branch of endoscopic technology. While OCT technology has high resolution, it also has large tomographic capabilities, and can be easily combined with fiber optic catheters and endoscopes to image internal organs of the human body. In particular, endoscopic frequency-domain OCT can realize high-speed real-time...

AI Technical Summary

Problems solved by technology

[0004] The existing OCT-Raman endoscopic probe has the following problems: First, although the existing Raman endoscopic system can obtain the Raman spectrum of the endoscopic image and its corresponding position, the Raman spectrum itself exists in the form of spectral lines , complex data analysis is required to realize the analysis of lesions, the degree of correlation with the imaging endoscopic image is low, the position correspondence is not obvious, the degree of visualization is low, and the abnormality and lesion cannot be clearly judged

Secondly, in the cavity endoscopy system, the imaging position of the endoscopic probe is limited by the position of the imaging catheter in the cavity, and its imaging center is not in the center of the blood vessel. Although this has no great impact on endoscopic imaging, it is very important for Raman detection The detection distance greatly affects the intensity of the Raman signal

Finally, the mechanical rotation scanning of most endoscopic catheters is realized by torsion cables. In the detection of large-length cavities, there is a problem of uneven rotation speed that leads to uniform image distortion, and its rotation speed and stability are affected to a certain extent. degree of limitation

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