Titanium-based implant capable of selectively expressing multiple functions of "stain resistance-cell adhesion promotion-sterilization" in response to temperature changes and preparation method

A temperature change, implant technology, applied in the medical field, to achieve the effect of excellent antibacterial properties and biocompatibility, broad application prospects, and broad clinical application prospects

Active Publication Date: 2020-12-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, previous studies have found that due to the enrichment of antibacterial peptides on the surface, certain cytotoxicity will be produced, which limits its application.

Method used

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  • Titanium-based implant capable of selectively expressing multiple functions of "stain resistance-cell adhesion promotion-sterilization" in response to temperature changes and preparation method
  • Titanium-based implant capable of selectively expressing multiple functions of "stain resistance-cell adhesion promotion-sterilization" in response to temperature changes and preparation method
  • Titanium-based implant capable of selectively expressing multiple functions of "stain resistance-cell adhesion promotion-sterilization" in response to temperature changes and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A method for preparing a titanium-based implant capable of selectively expressing the multifunctional function of "anti-fouling-promoting cell adhesion-sterilizing" in response to temperature changes, comprising the following steps (refer to figure 1 shown):

[0050] (1) Add 2.0g of 2-methyl-2-acrylic acid-2-(2-methoxyethoxy) ethyl ester (MEO 2 MA) and 0.4 g of oligoethylene glycol methyl ether methacrylate (OEGMA) were mixed with 20 mL of N,N-dimethylformamide (DMF), and the 2 Put it on the magnetic stirrer at 80°C and 600rpm in the state, add the initiator 4-cyano-4-(phenylthioformylthio)pentanoic acid (AIBN), polymerize for 50h, and obtain the number average molecular weight Mn of 80000 M(EO) 2 MA-co-OEGMA (MPEG); dialyzed, spin-dried.

[0051](2) The titanium-based material was ultrasonically cleaned by ethanol and deionized water for 15 minutes respectively, and then treated with hydrofluoric acid with a concentration of 10% by volume for 1 minute and concentrat...

Embodiment 2

[0059] (1) 2.0g 2-methyl-2-propenoic acid-2-(2-methoxyethoxy)ethyl ester (MEO 2 MA) and 0.4g of oligoethylene glycol methyl ether methacrylate (OEGMA) mixed with 20mL of N,N-dimethylformamide (DMF), in N 2 Put it on the magnetic stirrer at 80°C and 600rpm in the state, add the initiator 4-cyano-4-(phenylthioformylthio)pentanoic acid (AIBN), polymerize for 5h, and obtain the number average molecular weight Mn of 5000 M(EO) 2 MA-co-OEGMA (MPEG). Dialyze and spin dry.

[0060] (2) The titanium-based material was ultrasonically cleaned by ethanol and deionized water for 15 minutes respectively, and then treated with hydrofluoric acid with a concentration of 10% by volume for 1 minute and concentrated nitric acid with a mass fraction of 65% for 10 minutes, cleaned, and dried with nitrogen .

[0061] (3) Dissolving the MPEG described in the step (1) in absolute ethanol to prepare a reaction solution, the composition of which is: 240 mM sodium borohydride, 8000 μM MPEG solution. ...

Embodiment 3

[0068] (1) 2.0g 2-methyl-2-propenoic acid-2-(2-methoxyethoxy)ethyl ester (MEO 2 MA) and 0.4 g of oligoethylene glycol methyl ether methacrylate (OEGMA) were mixed with 20 mL of N,N-dimethylformamide (DMF), and the 2 Put it on the magnetic stirrer at 30°C and 250rpm in the state, add the initiator 4-cyano-4-(phenylthioformylthio)pentanoic acid (AIBN), polymerize for 5h, and obtain the number average molecular weight Mn of 3000 M(EO) 2 MA-co-OEGMA (MPEG). Dialyze and spin dry.

[0069] (2) The titanium-based material was ultrasonically cleaned by ethanol and deionized water for 15 minutes respectively, and then treated with hydrofluoric acid with a concentration of 10% by volume for 1 minute and concentrated nitric acid with a mass fraction of 65% for 10 minutes, cleaned, and blown with nitrogen. Dry.

[0070] (3) Dissolving the MPEG described in the step (1) in absolute ethanol to prepare a reaction solution, the composition of which is: 240 mM sodium borohydride, 8000 μM M...

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Abstract

The invention discloses a titanium-based implant capable of selectively expressing multiple functions of "stain resistance-cell adhesion promotion-sterilization" in response to temperature changes andpreparation method. The method comprises the following steps: synthesizing MEO2MA-co-OEGMA (MPEG) by utilizing a reversible addition-fragmentation chain transfer polymerization (RAFT) technology andcombining MEO2MA and OEGMA; performing pretreatment on the titanium-based implant by utilizing hydrofluoric acid and concentrated nitric acid, and then immersing the implant in an MPEG solution for agrafting reaction; and immersing the implant into an antibacterial polypeptide solution after cleaning for the grafting reaction to obtain the titanium-based implant capable of selectively expressingthe multiple functions of stain resistance, cell adhesion promotion and sterilization in response to the temperature changes. The multifunctional titanium-based implant constructed by the invention can selectively express the stain resistance property, the cell adhesion promotion property and the sterilization property according to the temperature changes, and has a wide application prospect in clinical orthopaedics.

Description

technical field [0001] The invention belongs to the field of medical technology, and specifically relates to a titanium-based implant capable of selectively expressing the multifunctional functions of "anti-fouling-promoting cell adhesion-sterilizing" in response to temperature changes and a preparation method thereof. Background technique [0002] Orthopedic implant materials are one of the most clinically used high-end medical devices. Titanium-based implants are widely used to treat some bone defects due to their excellent mechanical properties and biocompatibility. One of the implant materials. However, bacterial infection has always been a common problem faced by clinical orthopedic titanium-based implants. The surface functionalization of titanium-based implants with antibacterial peptides can effectively inhibit bacterial infection. However, previous studies have found that due to the enrichment of antibacterial peptides on the surface, certain cytotoxicity will be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/06A61L27/22A61L27/54A61L27/50C08F293/00
CPCA61L27/06A61L27/18A61L27/22A61L27/50A61L27/54A61L2300/252A61L2300/404A61L2430/02C08F293/005C08F2438/03C08L71/02
Inventor 王琳周海艳陈云华陈军建范燕徐铭健方舟郭锟忠
Owner SOUTH CHINA UNIV OF TECH
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