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Monosaccharide functionalized organic nano soft ball and preparation method thereof

A functional, monosaccharide technology, applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., can solve the problems of slow spontaneous degradation rate, affecting the health of the body, embolism of cells, etc., to avoid the reduction of surface charge, promote wound healing, promote The effect of polarization

Active Publication Date: 2022-04-05
NANJING UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the SiO2 nanoparticles are highly regular and stable hard particles, the spontaneous degradation rate in the body is slow, so the accumulation of nanoparticles in the body will cause embolism and toxicity to cells, which will affect the body. healthy

Method used

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  • Monosaccharide functionalized organic nano soft ball and preparation method thereof
  • Monosaccharide functionalized organic nano soft ball and preparation method thereof
  • Monosaccharide functionalized organic nano soft ball and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] S1. Preparation of dendritic peptide macromolecules

[0073] (1) Take a 500mL two-necked spherical flask, add 200mL of methanol into it, and slowly drop in 15mL of 3-aminopropyltriethoxysilane under stirring, then heat the oil bath to 50°C, condense and reflux, and use a 50mL constant pressure Add 30mL of concentrated hydrochloric acid dropwise into the dropping funnel, then raise the temperature to 90°C, stir and react for 24 hours, then add the reaction solution into the stirred tetrahydrofuran, centrifuge three times at 3000rpm×5min, discard the liquid, and dry in a vacuum oven to obtain cage polymer Type semisiloxane core POSS.

[0074] (2) Weigh POSS 1g, BOC-Lys(BOC)-OH 2.83g, HBTU 3.71g, HoBt 1.32g, dissolve in anhydrous DMSO under the protection of nitrogen, put the whole system in ice bath for 15min, add 5mL DIEA, After reacting for 24 hours, add 50 mL of chloroform to dilute, then wash with saturated saline for 3-5 times, use anhydrous magnesium sulfate to dry...

Embodiment 2

[0081] S1. Preparation of dendritic peptide macromolecules

[0082] (1) Take a 500mL two-necked spherical flask, add 200mL of methanol into it, and slowly drop in 15mL of 3-aminopropyltriethoxysilane under stirring, then heat the oil bath to 50°C, condense and reflux, and use a 50mL constant pressure Add 30mL of concentrated hydrochloric acid dropwise into the dropping funnel, then raise the temperature to 90°C, stir and react for 24 hours, then add the reaction solution into the stirred tetrahydrofuran, centrifuge three times at 3000rpm×5min, discard the liquid, and dry in a vacuum oven to obtain cage polymer Type semisiloxane core POSS.

[0083] (2) Weigh POSS 1g, BOC-Lys(BOC)-OH 2.83g, HBTU 3.71g, HoBt 1.32g, dissolve in anhydrous DMSO under the protection of nitrogen, put the whole system in ice bath for 15min, add 5mL DIEA, After reacting for 24 hours, add 50 mL of chloroform to dilute, then wash with saturated saline for 3-5 times, use anhydrous magnesium sulfate to dry...

Embodiment 3

[0090] S1. Preparation of dendritic peptide macromolecules

[0091] (1) Take a 500mL two-necked spherical flask, add 200mL of methanol into it, and slowly drop in 15mL of 3-aminopropyltriethoxysilane under stirring, then heat the oil bath to 50°C, condense and reflux, and use a 50mL constant pressure Add 30mL of concentrated hydrochloric acid dropwise into the dropping funnel, then raise the temperature to 90°C, stir and react for 24 hours, then add the reaction solution into the stirred tetrahydrofuran, centrifuge three times at 3000rpm×5min, discard the liquid, and dry in a vacuum oven to obtain cage polymer Type semisiloxane core POSS.

[0092] (2) Weigh POSS 1g, BOC-Lys(BOC)-OH 2.83g, HBTU 3.71g, HoBt 1.32g, dissolve in anhydrous DMSO under the protection of nitrogen, put the whole system in ice bath for 15min, add 5mL DIEA, After reacting for 24 hours, add 50 mL of chloroform to dilute, then wash with saturated saline for 3-5 times, use anhydrous magnesium sulfate to dry...

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Abstract

The invention provides a monosaccharide functionalized organic nano soft sphere, which is a monosaccharide functionalized dendritic peptide nano material obtained by grafting lysine dendritic macromolecules and monosaccharide under the catalysis of sodium cyanoborohydride. Wherein the lysine dendrimer is one of a first generation lysine dendrimer PG1 taking polyhedral oligomeric silsesquioxane (POSS) as a core, a second generation lysine dendrimer PG2 taking POSS as a core, or a third generation lysine dendrimer PG3 taking POSS as a core. The invention also provides a preparation method of the monosaccharide functionalized organic nano soft ball for inflammation inhibition. The nano soft sphere induces mannose receptor clusters on the surfaces of macrophages to polarize the macrophages to anti-inflammatory M2 phenotypes, so that the anti-inflammatory effect is achieved, wound healing is promoted, and the nano soft sphere can also be used for treating tissue and organ malignant inflammation.

Description

technical field [0001] The invention belongs to the technical field of polypeptide nanomaterials, and in particular relates to a monosaccharide functionalized organic nano soft ball and a preparation method thereof. Background technique [0002] Wound healing is considered to be a highly complex and orderly physiological process involving signal mediators, immune cells and stromal cells. The wound healing process includes four highly precise and orderly processes: hemostasis, inflammation, proliferation, and when the body is injured, various immune cells are absorbed and work together with the immune cells present in the skin to maintain or repair the function of the skin tissue . However, wound healing often faces tough environmental challenges due to its diseases (such as diabetes, obesity, etc.) and external factors (bacterial infection, etc.). [0003] Macrophages are mature myeloid cells derived primarily from the differentiation of circulating monocytes following tis...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K35/15A61K47/42A61P17/02A61P29/00B82Y5/00B82Y40/00
CPCY02P20/55
Inventor 何一燕姜于航徐爽爽李明蒋寒彭万佳顾忠伟
Owner NANJING UNIV OF TECH
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