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Adhesive healing-promoting hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and oxidized hyaluronic acid, which is applied in the fields of medical formula, medical science, absorbent pads, etc., can solve the problems of inability to promote wound healing, limited embolization effect, poor mechanical strength, etc., and achieve long-term high-efficiency promotion of healing, Effect of preventing displacement and good affinity effect

Active Publication Date: 2020-12-01
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The swelling rate of the first section of the seal is low, and after expansion, the mechanical strength is poor, and the embolism effect is limited.
And the seal does not play a role in promoting wound healing

Method used

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  • Adhesive healing-promoting hemostatic sponge and preparation method thereof
  • Adhesive healing-promoting hemostatic sponge and preparation method thereof
  • Adhesive healing-promoting hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 2.5% (the degree of oxidation is 50%, the grafting rate of dopamine is 7.5%, and the molecular weight is 37-56KDa), 0.75% exosomes, 20% acrylic acid, Add 0.015% N, N'-methylene bisacrylamide into purified water, stir at 100-200rpm until completely dissolved, add dropwise sodium hydroxide solution to neutrality, add 0.6% ammonium persulfate, 0.3% hydrogen sulfite Sodium, stirred evenly at 100-200rpm, reacted at 60°C for 1.5h under the protection of nitrogen to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze dryer at -50°C for 6 hours, and vacuum...

Embodiment 2

[0048] Example 2 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 3.5% (the degree of oxidation is 40%, the grafting rate of dopamine is 5%, and the molecular weight is 8-10KDa), 0.5% exosomes, 15% acrylic acid, Add 0.01% N, N'-methylenebisacrylamide into purified water, stir at 100-200rpm until completely dissolved, add disodium hydrogen phosphate solution to neutrality, add 0.4% ammonium persulfate, 0.2% sulfurous acid Sodium hydrogen, stirred evenly at 100-200rpm, reacted at 60°C for 1.5h under nitrogen protection, to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze dryer at -50°C for 6 hours, and vacuumed ...

Embodiment 3

[0049] Example 3 Dopamine grafted oxidized sodium hyaluronate with a mass fraction of 1.5% (the degree of oxidation is 60%, the grafting rate of dopamine is 10%, and the molecular weight is 60-80KDa), 1.0% exosomes, 25% acrylic acid, Add 0.02% N, N'-methylenebisacrylamide into purified water, stir at 100-200rpm until completely dissolved, add dropwise sodium bicarbonate solution until neutral, add 0.7% ammonium persulfate, 0.3% bisulfite Sodium, stirred evenly at 100-200rpm, reacted at 60°C for 1.5h under the protection of nitrogen to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze dryer at -50°C for 6 hours, and vacuumed after ...

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Abstract

The invention discloses an adhesive healing-promoting hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared by neutralizing dopamine-grafted oxidized sodium hyaluronate, exosome, acrylic acid and N,N'-methylene bisacrylamide, adding a redox initiator for cross-linking, and performing freeze-drying according to a program. The hemostatic sponge prepared by the methodnot only can quickly absorb blood or tissue fluid to form gel, form mechanical compression on damaged blood vessels on the surface of a cavity and promote hemostasis, but also can be adhered to the surface of the cavity, so that displacement is prevented while hemostasis is further promoted. After the hemostatic sponge absorbs the blood or tissue fluid, dynamic bonds can be formed, and the hemostatic sponge has a certain self-repairing function. In addition, sodium hyaluronate and exosome with specific molecular weights can be continuously released while efficient hemostasis is achieved, and wound healing is promoted. Therefore, the hemostatic sponge has the effects of rapid and efficient hemostasis, adhesion, self-repairing and healing promotion.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an adhesive hemostatic sponge capable of promoting healing and a preparation method thereof. The medical hemostatic sponge of the present application has the functions of inflatable and fast hemostasis, adhesion, displacement prevention, self-repair and healing promotion. Background technique [0002] In the first aid of sudden accidents, surgery and in war, 50% of the deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability, and the hemostatic effect is not very satisfactory. Therefore, the development of highly efficient and quickly absorbable hemostatic materials and products, which can effectively stop bleeding within 1-2 minutes or even shorter after the bleeding occurs, has become one of the main goals of the research and development o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/62A61L15/44A61L15/24A61L15/28C08F251/00C08F220/06C08F222/38
CPCA61L15/225A61L15/42A61L15/425A61L15/44A61L15/62A61L2300/236A61L2300/412A61L2300/602A61L2400/04C08F251/00C08L51/02C08L5/08C08F220/06C08F222/385
Inventor 张海军袁坤山车超越张淑欣侯文博尹玉霞鲁守涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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