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Formula for resisting bacteria and resisting inflammation and toothpaste for resisting bacteria and resisting inflammation

A formulation and toothpaste technology, which is applied in the field of daily chemical products, can solve the problems of bacterial flora imbalance and drug resistance, achieve comprehensive effects, prevent oral foaming, and promote the effect of clearing away heat and eliminating fire

Inactive Publication Date: 2020-11-27
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The more effective bactericidal ingredients in current toothpaste formulations are mainly antibiotics, but long-term use of antibiotics may lead to adverse consequences such as flora imbalance and drug resistance. toothpaste

Method used

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  • Formula for resisting bacteria and resisting inflammation and toothpaste for resisting bacteria and resisting inflammation
  • Formula for resisting bacteria and resisting inflammation and toothpaste for resisting bacteria and resisting inflammation
  • Formula for resisting bacteria and resisting inflammation and toothpaste for resisting bacteria and resisting inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 antibacterial and anti-inflammatory prescription

[0038] Antibacterial and anti-inflammatory prescriptions were configured according to the dosage in Table 1.

[0039] Table 1

[0040]

[0041]

[0042] The green tea extract in Table 1 is obtained by Soxhlet extraction of green tea using 80% ethanol as a solvent, and filtering the extract. The specific extraction process is as follows:

[0043] (1) Take dried green tea leaves, pulverize them into powder with a traditional Chinese medicine pulverizer, pass through a 40-mesh sieve, accurately weigh 20 g of the powder, and place it in an extraction cylinder.

[0044] (2) Weigh 200ml of 80% ethanol, pour it into a flask from the extraction cylinder, put in zeolite, install a Soxhlet extraction device, and heat to reflux for 2 hours.

[0045] (3) When the siphon phenomenon occurs 4 times, and the color of the extract in the extraction cylinder becomes very light, stop heating, remove the electric heati...

Embodiment 2

[0053] The in vitro bacteriostatic activity test of embodiment 2 antibacterial and anti-inflammatory prescriptions

[0054] 1. Test method

[0055] (1) Tested strains: Candida albicans (ATCC 10231), Staphylococcus aureus (ATCC 6538), Streptococcus mutans (ATCC 25175), Porphyromonas gingivalis (ATCC 49417), Helicobacter pylori (ATCC 43629) , Escherichia coli (ATCC 35132), Prevotella intermedia (ATCC 25611), Fusobacterium nucleatum (ATCC 51190).

[0056] Medium: BHI liquid medium, CDC anaerobic agar medium.

[0057] (2) Antibacterial test method

[0058] The MIC and MBC of the test samples against bacteria were determined by the double dilution method.

[0059] (3) Preparation of bacterial suspension

[0060] Candida albicans (ATCC 10231), Staphylococcus aureus (ATCC 6538), Streptococcus mutans (ATCC25175), Porphyromonas gingivalis (ATCC 49417), Helicobacter pylori (ATCC 43629), Escherichia coli (ATCC35132 ), Prevotella intermedia (ATCC 25611), and Fusobacterium nucleatum (...

Embodiment 3

[0072] Embodiment 3 antibacterial and anti-inflammatory toothpaste

[0073] 1. The formula of antibacterial and anti-inflammatory toothpaste is shown in Table 3

[0074] table 3

[0075]

[0076] 2. Preparation method of toothpaste

[0077] S1. Add thickener and humectant to the reactor, stir at 1000rpm for 20 minutes until there are no obvious particles;

[0078] S2. Dissolve the preservative and sweetener in 50% deionized water. After fully dissolving, add the solution into the reactor in step S1, and stir at 1000 rpm for 20 minutes until the colorless and transparent colloidal solution is ready for use;

[0079] S3. add friction agent in the reactor, stir at 600rpm for 10 minutes until the color of the colloidal substance in the reactor is uniform, no particles, no fine powder;

[0080] S4. Dissolve the surfactant in the remaining 50% deionized water, then add zedoary oil, oregano oil, chrysanthemum oil, peppermint oil, coconut oil and green tea extract to the solutio...

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Abstract

The invention discloses a formula for resisting bacteria and resisting inflammation and toothpaste for resisting bacteria and resisting inflammation. The formula for resisting bacteria and resisting inflammation comprises oleum curcumae, coconut oil, peppermint oil, cretian origanum oil, chrysanthemum oil and a green tea extract, natural plant components are effectively compounded, and breeding and propagation of varied oral cavity harmful bacteria in oral cavity and surfaces of teeth can be restrained, halitosis can be avoided, bad breath can be refreshed, and acting force is durable. A toothpaste product having efficacy of resisting bacteria and resisting inflammation is further developed. The toothpaste can effectively promote the effects of clearing heat, reducing fire, preventing oralcavity blistering, resisting bacteria, diminishing inflammation, solidifying teeth, refreshing bad breath and preventing halitosis, the problems of oral cavity peculiar smell, buccal inflammation, dental ulcer and the like can be comprehensively solved in a targetted manner, and the problem that gum suffers from excessive internal heat can be solved.

Description

technical field [0001] The invention belongs to the technical field of daily chemical products. More specifically, it relates to an antibacterial and anti-inflammatory formula and an antibacterial and anti-inflammatory toothpaste. Background technique [0002] In modern society, people's eating habits have become diversified and complicated, but the cleaning of the mouth and teeth has not received corresponding attention. In addition, incorrect brushing methods often cause a large amount of fine food debris to remain on the surface of the mouth and teeth , and our mouth is the starting point of the digestive tract, where there are tens of billions of various bacteria. In the weak acid environment of the oral cavity, most of these bacteria can reproduce in large numbers on the surface of the teeth containing food residues. Over time, they will change the color of the teeth, form dental caries, and may even develop dental diseases such as pulpitis and apical periodontitis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/92A61Q11/00A61P1/02A61P29/00A61P31/02
CPCA61K8/9789A61K8/922A61Q11/00A61P1/02A61P29/00A61P31/02A61K2800/5922
Inventor 张蓝月李春莲陈钰槟潘春杏徐雅妮石耀辉罗怡杰向洪平
Owner GUANGDONG UNIV OF TECH
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