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Non-invasive measurement method for aortic stiffness of rat model

A technology of rat model and measurement method, applied in the field of medical research, can solve problems such as ignoring arterial stiffness

Pending Publication Date: 2020-11-24
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if you think about it carefully, it is not difficult to find that the carotid-femoral PWV, which is most commonly used to evaluate aortic AS, actually ignores the arterial stiffness of the initial segment of the aorta

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  • Non-invasive measurement method for aortic stiffness of rat model
  • Non-invasive measurement method for aortic stiffness of rat model
  • Non-invasive measurement method for aortic stiffness of rat model

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with the accompanying drawings and examples, and the contents of the examples are not intended to limit the protection scope of the present invention.

[0027] The invention relates to a non-invasive measurement method for rat model aorta stiffness, which belongs to a new method for measuring the pulse wave propagation distance of the rat model aorta PWV. In the following, we first describe the newly proposed method for measuring the propagation distance of the aortic pulse wave in the rat model.

[0028] As mentioned above, the purpose of determining the propagation distance of the aortic pulse wave is to calculate the aortic PWV. Referring to the clinical measurement method, the carotid-femoral pulse wave propagation distance is usually selected (because the measurement points of the common carotid artery and the common femoral artery are close to the body surface , easy to measure) and then determin...

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Abstract

The invention relates to a non-invasive measurement method of rat model aortic stiffness, which comprises the following steps: (1) measuring the linear distance from the nose tip to the tail root of arat, namely the body length L (mm); (2) carrying out ultrasonic Doppler noninvasive measurement on the rat neck-femoral pulse wave propagation time and the heart-femoral pulse wave propagation time of the rat; (3) calculating the aortic pulse wave propagation velocity (PWV) of the rat model: rat neck-femoral PWV = (0.4614 * L + 1.8335) / neck-femoral pulse wave propagation time; wherein the rat heart-femur PWV is equal to (0.6086 * L <-1.6523 >) / heart-femur pulse wave propagation time. The method is very simple and easy to operate, and the result is more accurate.

Description

technical field [0001] The invention belongs to the technical field of medical research, relates to a technical method in the relevant fields of biology and basic medicine cardiovascular, in particular to a non-invasive measurement method for aortic stiffness of a rat model. Background technique [0002] Arterial stiffness (Arterial Stiffness, AS) is one of the earliest detectable indicators in the process of human arterial wall aging and gradually reducing elasticity under aging and various pathological conditions. A number of authoritative studies have confirmed that aortic AS is a powerful independent predictor of cardiovascular disease and all-cause mortality. Najjar et al. confirmed that aortic AS is also an independent predictor of future hypertension in the general population; Cruickshank et al. also found that in a multi-ethnic population with glucose tolerance and / or diabetes, aortic AS was an independent predictor of all-cause Mortality and cardiovascular disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/02A61B8/06A61B5/0402A61B5/107
CPCA61B8/02A61B8/06A61B8/0891A61B8/488A61B5/1072A61B2503/40A61B2503/42A61B5/02007
Inventor 王臻付子豪高峰
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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